دورية أكاديمية
أعرض في EDS

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review.

التفاصيل البيبلوغرافية
العنوان: Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review.
المؤلفون: Zarenezhad E; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran., Abdulabbas HT; Department of Medical Microbiology, Medical College, Al Muthanna University, Al Muthanna, Iraq., Kareem AS; Department of Medical Laboratories Techniques, Imam Ja'afar Al-Sadiq University, Al-Muthanna, 66002, Iraq., Kouhpayeh SA; Department of Pharmacology, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran., Barbaresi S; Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium., Najafipour S; Department of Microbiology, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran., Mazarzaei A; Department of Immunology, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran., Sotoudeh M; Department of Nutrition, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran., Ghasemian A; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. majidghasemian86@gmail.com.
المصدر: Archives of microbiology [Arch Microbiol] 2023 May 30; Vol. 205 (6), pp. 252. Date of Electronic Publication: 2023 May 30.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0410427 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-072X (Electronic) Linking ISSN: 03028933 NLM ISO Abbreviation: Arch Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH: Epstein-Barr Virus Infections* , Silymarin*/pharmacology , Inflammatory Bowel Diseases*/drug therapy, Humans ; Herpesvirus 4, Human/genetics ; Quercetin/pharmacology ; Flavonoids ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use
مستخلص: Inflammatory bowel disease (IBD) is a chronic recurrent inflammation of the gastrointestinal tract (GIT). IBD patients are susceptible to various infections such as viral infections due to the long-term consumption of immunosuppressive drugs and biologics. The antiviral and IBD protective traits of flavonoids have not been entirely investigated. This study objective included an overview of the protective role of flavonoids quercetin and silymarin in viral-associated IBD. Several viral agents such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella zoster virus (VZV) and enteric viruses can be reactivated and thus develop or exacerbate the IBD conditions or eventually facilitate the disease remission. Flavonoids such as quercetin and silymarin are non-toxic and safe bioactive compounds with remarkable anti-oxidant, anti-inflammatory and anti-viral effects. Mechanisms of anti-inflammatory and antiviral effects of silymarin and quercetin mainly include immune modulation and inhibition of caspase enzymes, viral binding and replication, RNA synthesis, viral proteases and viral assembly. In the nutraceutical sector, natural flavonoids low bioavailability and solubility necessitate the application of delivery systems to enhance their efficacy. This review study provided an updated understanding of the protective role of quercetin and silymarin against viral-associated IBD.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Antiviral traits; Inflammatory bowel diseases; Quercetin; Silymarin; Viral infections
المشرفين على المادة: 9IKM0I5T1E (Quercetin)
0 (Silymarin)
0 (Flavonoids)
0 (Antiviral Agents)
تواريخ الأحداث: Date Created: 20230530 Date Completed: 20230601 Latest Revision: 20230613
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10228462
DOI: 10.1007/s00203-023-03590-0
PMID: 37249707
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-072X
DOI:10.1007/s00203-023-03590-0