دورية أكاديمية
Simultaneous toxicokinetic studies of aristolochic acid I and II and aristolactam I and II using a newly-developed microdialysis liquid chromatography-tandem mass spectrometry.
| العنوان: | Simultaneous toxicokinetic studies of aristolochic acid I and II and aristolactam I and II using a newly-developed microdialysis liquid chromatography-tandem mass spectrometry. |
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| المؤلفون: | Chiang SY; School of Chinese Medicine, College of Chinese Medicine, China Medical University, No. 91, Hsueh-Shih Rd, North Dist., Taichung, 404333, Taiwan., Wey MT; Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Zhongzheng Dist., Taipei, 100025, Taiwan., Luo YS; Institute of Food and Health, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Zhongzheng Dist., Taipei, 404333, Taiwan., Shih WC; Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Zhongzheng Dist., Taipei, 100025, Taiwan., Chimeddulam D; Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Zhongzheng Dist., Taipei, 100025, Taiwan., Hsu PC; School of Chinese Medicine, College of Chinese Medicine, China Medical University, No. 91, Hsueh-Shih Rd, North Dist., Taichung, 404333, Taiwan., Huang HF; School of Post-baccalaureate Chinese Medicine, Tzu Chi University, Hualien, 97004, Taiwan., Tsai TH; Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2. Linong St., Taipei, 100147, Taiwan., Wu KY; Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Zhongzheng Dist., Taipei, 100025, Taiwan; Institute of Food and Health, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Zhongzheng Dist., Taipei, 404333, Taiwan; Department of Public Health, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Zhongzheng Dist., Taipei, 100025, Taiwan. Electronic address: kuenyuhwu@ntu.edu.tw. |
| المصدر: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2023 Jul; Vol. 177, pp. 113856. Date of Electronic Publication: 2023 May 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Exeter : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1982- |
| مواضيع طبية MeSH: | Aristolochic Acids*/chemistry , Aristolochic Acids*/pharmacokinetics , Aristolochic Acids*/pharmacology , Balkan Nephropathy* , Kidney Diseases* , Lactams*/chemistry , Lactams*/pharmacokinetics , Lactams*/pharmacology, Animals ; Rats ; Chromatography, Liquid/methods ; Microdialysis ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry/methods ; Toxicokinetics |
| مستخلص: | Aristolochic acids (AAs) are naturally occurring genotoxic carcinogens linked to Balkan endemic nephropathy and aristolochic acid nephropathy. Aristolochic acid I and II (AA-I and AA-II) are the most abundant AAs, and AA-I has been reported to be more genotoxic and nephrotoxic than AA-II. This study aimed to explore metabolic differences underlying the differential toxicity. We developed a novel microdialysis sampling coupled with solid-phase extraction liquid chromatography-tandem mass spectrometry (MD-SPE-LC-MS/MS) to simultaneously study the toxicokinetics (TK) of AA-I and AA-II and their corresponding aristolactams (AL-I and AL-II) in the blood of Sprague Dawley rats co-treated with AA-1 and AA-II. Near real-time monitoring of these analytes in the blood of treated rats revealed that AA-I was absorbed, distributed, and eliminated more rapidly than AA-II. Moreover, the metabolism efficiency of AA-I to AL-I was higher compared to AA-II to AL-II. Only 0.58% of AA-I and 0.084% of AA-II was reduced to AL-I and AL-II, respectively. The findings are consistent with previous studies and support the contention that differences in the in vivo metabolism of AA-I and AA-II may be critical factors for their differential toxicities. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aristolactam; Aristolochic acid; Balkan endemic nephropathy; In vivo microdialysis; Liquid chromatography-tandem mass spectrometry; Toxicokinetics |
| المشرفين على المادة: | 13395-02-3 (aristolactam I) 94218WFP5T (aristolochic acid I) 0 (Aristolochic Acids) 0 (aristolactam II) 0 (Lactams) |
| تواريخ الأحداث: | Date Created: 20230531 Date Completed: 20230616 Latest Revision: 20240612 |
| رمز التحديث: | 20240612 |
| DOI: | 10.1016/j.fct.2023.113856 |
| PMID: | 37257633 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6351 |
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| DOI: | 10.1016/j.fct.2023.113856 |