دورية أكاديمية
Intraoperative evaluation of sentinel lymph nodes in patients with breast cancer treated with systemic neoadjuvant therapy.
| العنوان: | Intraoperative evaluation of sentinel lymph nodes in patients with breast cancer treated with systemic neoadjuvant therapy. |
|---|---|
| المؤلفون: | Huerta-Rosario M; Facultad de Medicina, Universidad Señor de Sipán, Chiclayo, Peru.; Red de Eficacia Clínica y Sanitaria, REDECS, Lima, Peru., Mir M; Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Quispe-Vicuña C; Red de Eficacia Clínica y Sanitaria, REDECS, Lima, Peru.; Sociedad Científica de San Fernando, Lima, Peru., Hwang H; Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Sarode V; Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Peng Y; Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Fang Y; Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Leitch M; Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Sahoo S; Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA Sunati.Sahoo@UTSouthwestern.edu. |
| المصدر: | Journal of clinical pathology [J Clin Pathol] 2024 Jul 18; Vol. 77 (8), pp. 544-550. Date of Electronic Publication: 2024 Jul 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0376601 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-4146 (Electronic) Linking ISSN: 00219746 NLM ISO Abbreviation: J Clin Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : BMJ Pub. Group Original Publication: London : British Medical Association |
| مواضيع طبية MeSH: | Breast Neoplasms*/pathology , Breast Neoplasms*/therapy , Breast Neoplasms*/surgery , Neoadjuvant Therapy* , Sentinel Lymph Node*/pathology , Sentinel Lymph Node Biopsy* , Frozen Sections* , Lymphatic Metastasis*, Humans ; Female ; Middle Aged ; Aged ; Adult ; Sensitivity and Specificity ; Aged, 80 and over ; Intraoperative Period |
| مستخلص: | Aims: Touch preparation (TP) and frozen section (FS) are the two methods routinely used in the intraoperative evaluation (IOE) of sentinel lymph nodes (SLNs) to detect metastases in patients with breast cancer. Both methods are extremely sensitive and specific in the primary surgery (non-neoadjuvant systemic therapy (non-NST)) setting. Since NST introduces unique challenges in the IOE of SLNs, the aim was to determine the accuracy of TP and FS in the IOE of SLNs in the NST setting and compare the results with the non-NST setting and to examine factors that contribute to any differences. Methods: We analysed 871 SLNs from 232 patients (615 SLNs from NST and 256 SLNs from non-NST settings) between 2016 through 2019. Results: In the NST group, TP alone (n=366) had a sensitivity of 45.7% and specificity of 99.7%; FS alone (n=90) had a sensitivity of 83.3% and specificity of 100%. When both TP and FS (n=135) were used, the sensitivity was 80.3% and the specificity was 98.6%.In the non-NST group, TP alone (n=193) had a sensitivity of 66.7% and specificity of 100%; FS alone (n=22) had a sensitivity and specificity of 100%; and combined TP and FS (n=34) had a sensitivity and specificity of 100% and 96%, respectively. Conclusions: Evaluating SLNs intraoperatively in the NST setting can be challenging secondary to therapy-related changes. In the NST setting, FS has higher sensitivity and specificity compared with TP for the IOE of SLNs and should be the preferred method. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.) |
| فهرسة مساهمة: | Keywords: Breast Neoplasms; Neoplasm Metastasis; Sentinel Lymph Node |
| تواريخ الأحداث: | Date Created: 20230531 Date Completed: 20240718 Latest Revision: 20240718 |
| رمز التحديث: | 20240719 |
| DOI: | 10.1136/jcp-2023-208862 |
| PMID: | 37258252 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1472-4146 |
|---|---|
| DOI: | 10.1136/jcp-2023-208862 |