دورية أكاديمية
أعرض في EDS

Innate Lymphoid Cells and Interferons Limit Neurologic and Articular Complications of Brucellosis.

التفاصيل البيبلوغرافية
العنوان: Innate Lymphoid Cells and Interferons Limit Neurologic and Articular Complications of Brucellosis.
المؤلفون: Moley CR; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri., Chambers CA; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri., Dadelahi AS; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri., Ponzilacqua-Silva B; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri., Abushahba MFN; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri; Department of Zoonoses, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt., Lacey CA; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri., Franklin CL; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri., Skyberg JA; Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri; Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri. Electronic address: skybergj@missouri.edu.
المصدر: The American journal of pathology [Am J Pathol] 2023 Sep; Vol. 193 (9), pp. 1170-1184. Date of Electronic Publication: 2023 May 30.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011-: New York : Elsevier
Original Publication: Philadelphia [etc.] American Assn. of Pathologists [etc.]
مواضيع طبية MeSH: Brucellosis*/complications , Brucellosis*/prevention & control , Arthritis*/complications, Humans ; Animals ; Mice ; Interferons ; Interferon-gamma ; Immunity, Innate ; Lymphocytes/pathology
مستخلص: Brucellosis is a globally significant zoonotic disease. Human patients with brucellosis develop recurrent fever and focal complications, including arthritis and neurobrucellosis. The current study investigated the role of innate lymphoid cells (ILCs) in the pathogenesis of focal brucellosis caused by Brucella melitensis. After footpad infection, natural killer cells and ILC1 cells both limited joint colonization by Brucella. Mice lacking natural killer cells, and in particular mice lacking all ILCs, also developed marked arthritis after footpad infection. Following pulmonary infection, mice lacking adaptive immune cells and ILCs developed arthritis, neurologic complications, and meningitis. Adaptive immune cells and ILCs both limited colonization of the brain by Brucella following pulmonary infection. Transcriptional analysis of Brucella-infected brains revealed marked up-regulation of genes associated with inflammation and interferon responses, as well as down-regulation of genes associated with neurologic function. Type II interferon deficiency resulted in colonization of the brain by Brucella, but mice lacking both type I and type II interferon signaling more rapidly developed clinical signs of neurobrucellosis, exhibited hippocampal neuronal loss, and had higher levels of Brucella in their brains than mice lacking type II interferon signaling alone. Collectively, these findings indicate ILCs and interferons play an important role in prevention of focal complications during Brucella infection, and that mice with deficiencies in ILCs or interferons can be used to study pathogenesis of neurobrucellosis.
(Copyright © 2023 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 AI150797 United States AI NIAID NIH HHS; R21 AI153074 United States AI NIAID NIH HHS; T32 OD011126 United States OD NIH HHS
المشرفين على المادة: 9008-11-1 (Interferons)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20230601 Date Completed: 20230825 Latest Revision: 20240902
رمز التحديث: 20240902
مُعرف محوري في PubMed: PMC10477959
DOI: 10.1016/j.ajpath.2023.05.006
PMID: 37263343
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-2191
DOI:10.1016/j.ajpath.2023.05.006