دورية أكاديمية
أعرض في EDS

The design and development of a study protocol to investigate Onchocerca volvulus, Loa loa and Mansonella perstans-mediated modulation of the metabolic and immunological profile in lean and obese individuals in Cameroon.

التفاصيل البيبلوغرافية
العنوان: The design and development of a study protocol to investigate Onchocerca volvulus, Loa loa and Mansonella perstans-mediated modulation of the metabolic and immunological profile in lean and obese individuals in Cameroon.
المؤلفون: Lenz B; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Andrew BA; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon., Ritter M; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Karunakaran I; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Gandjui NVT; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon., Nchang LC; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon., Surendar J; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Ebob AOB; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon., Ehrens A; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.; German Center for Infection Research (DZIF), Bonn, Germany., Klarmann-Schulz U; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.; German Center for Infection Research (DZIF), Bonn, Germany., Ricchiuto A; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Kuehlwein JM; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.; German Center for Infection Research (DZIF), Bonn, Germany., Fombad FF; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon., Ngwa AM; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon., Katcho TD; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon., Hoerauf A; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.; German Center for Infection Research (DZIF), Bonn, Germany.; German-West African Centre for Global Health and Pandemic Prevention (G-WAC), Bonn, Germany., Wanji S; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon., Hübner MP; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.; German Center for Infection Research (DZIF), Bonn, Germany.
المصدر: PloS one [PLoS One] 2023 Jun 02; Vol. 18 (6), pp. e0285689. Date of Electronic Publication: 2023 Jun 02 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Onchocerca volvulus* , Mansonelliasis*/parasitology , Diabetes Mellitus, Type 2* , Insulin Resistance* , Loiasis*/parasitology, Animals ; Humans ; Mansonella ; Loa ; Cameroon ; Obesity
مستخلص: Background: Life-style metabolic diseases are steadily rising, not only in developed countries, but also in low- and middle-income countries, presenting a global health problem. Metabolic disorders like type 2 diabetes and cardiovascular diseases are among the ten leading causes of death defined by the WHO in 2019. Results from animal and observational human studies suggest a connection between the decline in human helminth infections and rise of life-style-associated metabolic diseases in developing regions. This trial was designed to investigate filarial infections and their impact on metabolic diseases in Cameroon. We hypothesize that the induction of regulatory immune responses during filarial infection reduces obesity-induced low-grade inflammatory immune responses and thereby improves metabolic parameters, whereas anthelmintic treatment abolishes this protective effect.
Methods/design: Participants infected with Mansonella perstans, Onchocerca volvulus and/or Loa loa being lean (BMI <25), overweight (BMI >25 and <30) or clinically obese (BMI ≥30) from Littoral regions of Cameroon will be evaluated for their parasitological, immunological, metabolic and biochemical profile before and after treatment of their parasitic infections. Anthropomorphic measurements and a detailed questionnaire will complement our analysis. The investigation will assess blood immune cell populations, serum adipokines and cytokines that could be influenced by the parasite infection and/or metabolic diseases. Further, parameters like blood glucose, homeostatic model assessment of insulin resistance (HOMA-IR), circulating lipids and circulating makers of liver function will be monitored. Parameters will be assessed before treatment, 12 and 18 months after treatment.
Conclusion: The focus of this study is to obtain a comprehensive metabolic profile of the participants in rural areas of Cameroon and to investigate the relationship between filarial immunomodulation and metabolic diseases. This study will elucidate the effect of anti-filarial treatment on the metabolic and immunological parameters that partake in the development of insulin resistance, narrowing in on a potential protective effect of filarial infections on metabolic diseases.
Trial Registration: doi.org/10.1186/ISRCTN43845142, ISRCTN43845142 February 2020 Trial title Effects of filarial parasite infection on type 2 diabetes Issue date: 27.10.22, V.1.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Lenz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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تواريخ الأحداث: Date Created: 20230602 Date Completed: 20230605 Latest Revision: 20230616
رمز التحديث: 20230616
مُعرف محوري في PubMed: PMC10237473
DOI: 10.1371/journal.pone.0285689
PMID: 37267236
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0285689