دورية أكاديمية
Muscular involvement in long-term type 1 diabetes: Does it represent an underestimated complication?
| العنوان: | Muscular involvement in long-term type 1 diabetes: Does it represent an underestimated complication? |
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| المؤلفون: | Pollakova D; Diabetes Unit 'S.Camillo - Forlanini' Hospital, Rome, Italy. Electronic address: pollak.daniela@gmail.com., Tubili C; Diabetes Unit 'S.Camillo - Forlanini' Hospital, Rome, Italy., Di Folco U; Diabetes Unit 'S.Camillo - Forlanini' Hospital, Rome, Italy., De Giuseppe R; Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy; National Biodiversity Future Center, Palermo, Italy., Battino M; International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu University, Zhenjiang, China; Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy; Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Santander, Spain., Giampieri F; Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Santander, Spain. |
| المصدر: | Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2023 Aug; Vol. 112, pp. 112060. Date of Electronic Publication: 2023 May 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8802712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1244 (Electronic) Linking ISSN: 08999007 NLM ISO Abbreviation: Nutrition Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown, NY : Elsevier Science Original Publication: [Burbank, Calif. : Nutrition, c1987- |
| مواضيع طبية MeSH: | Sarcopenia*/epidemiology , Sarcopenia*/etiology , Sarcopenia*/diagnosis , Diabetes Mellitus, Type 1*/complications , Diabetes Mellitus, Type 1*/epidemiology, Male ; Humans ; Female ; Aged ; Adult ; Middle Aged ; Muscle Strength ; Body Mass Index ; Body Composition/physiology ; Muscle, Skeletal ; Hand Strength/physiology |
| مستخلص: | Objectives: Structural, metabolic, and functional signs of skeletal muscle damage have been identified in individuals affected by type 1 diabetes (T1D), but, to our knowledge, no guidelines for the diagnosis and treatment of muscle impairment exist and studies on T1D and muscle health remain limited. The aim of this study was to evaluate the prevalence of sarcopenia in a long-term T1D population and to assess the effects of some clinical parameters on muscle mass and function. Methods: Thirty-nine patients affected by T1D were enrolled. Body mass index (BMI), body composition (appendicular lean mass index [ALMI] and fat mass [FM]), and muscle strength were measured. Additionally, the relationship between Mediterranean diet adherence and sarcopenia was assessed. Results: In the present sample (mean age 49.32 ± 13.49 y, 41.1% women, mean duration of diabetes 30.13 ± 12.28 y), the prevalence of sarcopenia was 7.7% (12.5 % in women and 4.35% in men). The prevalence of low ALMI was 23.1% (25% in women and 21.74% in men). Significant inverse correlations were found between ALMI and duration of diabetes and ALMI and FM; and significant positive correlations between ALMI and BMI, physical activity level, and muscle strength. At the same time, significant inverse correlations were observed between muscle strength and duration of diabetes and muscle strength and FM. Conclusions: We observed a high prevalence of low muscle mass, similar to those found in the older age groups of the general population (25 years in advance) and our findings suggest a possible pathogenetic role of T1D duration on muscle trophism and function. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Accelerated muscle aging; Muscle function; Muscle mass; Sarcopenia; Type 1 diabetes |
| تواريخ الأحداث: | Date Created: 20230602 Date Completed: 20230616 Latest Revision: 20230628 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.nut.2023.112060 |
| PMID: | 37267657 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-1244 |
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| DOI: | 10.1016/j.nut.2023.112060 |