دورية أكاديمية
أعرض في EDS

Mosquito pericardial cells upregulate Cecropin expression after an immune challenge.

التفاصيل البيبلوغرافية
العنوان: Mosquito pericardial cells upregulate Cecropin expression after an immune challenge.
المؤلفون: Cardoso-Jaime V; Centro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública. Av. Universidad 655, Santa María Ahuacatitlan, Cuernavaca, Morelos, C.P. 62100, Mexico; Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados, IPN. Av. Instituto Politécnico Nacional 2508, Gustavo A. Madero, Ciudad de México, C.P. 07360, Mexico., Maya-Maldonado K; Centro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública. Av. Universidad 655, Santa María Ahuacatitlan, Cuernavaca, Morelos, C.P. 62100, Mexico; Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados, IPN. Av. Instituto Politécnico Nacional 2508, Gustavo A. Madero, Ciudad de México, C.P. 07360, Mexico., Tsutsumi V; Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados, IPN. Av. Instituto Politécnico Nacional 2508, Gustavo A. Madero, Ciudad de México, C.P. 07360, Mexico. Electronic address: vtsutsu@cinvestav.mx., Hernández-Martínez S; Centro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública. Av. Universidad 655, Santa María Ahuacatitlan, Cuernavaca, Morelos, C.P. 62100, Mexico. Electronic address: shernandez@insp.mx.
المصدر: Developmental and comparative immunology [Dev Comp Immunol] 2023 Oct; Vol. 147, pp. 104745. Date of Electronic Publication: 2023 May 31.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7708205 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0089 (Electronic) Linking ISSN: 0145305X NLM ISO Abbreviation: Dev Comp Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Tarrytown Ny : Elsevier Science
Original Publication: Elmsford, N. Y., Pergamon Press., 1977-2004.
مواضيع طبية MeSH: Cecropins* , Anopheles*, Animals ; Phagocytosis ; Immunity ; Pericardium ; Hemocytes
مستخلص: Most mosquito-transmitted pathogens grow or replicate in the midgut before invading the salivary glands. Pathogens are exposed to several immunological factors along the way. Recently, it was shown that hemocytes gather near the periostial region of the heart to efficiently phagocytose pathogens circulating in the hemolymph. Nerveless, not all pathogens can be phagocyted by hemocytes and eliminated by lysis. Interestingly, some studies have shown that pericardial cells (PCs) surrounding periostial regions, may produce humoral factors, such as lysozymes. Our current work provides evidence that Anopheles albimanus PCs are a major producer of Cecropin 1 (Cec1). Furthermore, our findings reveal that after an immunological challenge, PCs upregulate Cec1 expression. We conclude that PCs are positioned in a strategic location that could allow releasing humoral components, such as cecropin, to lyse pathogens on the heart or circulating in the hemolymph, implying that PCs could play a significant role in the systemic immune response.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
المشرفين على المادة: 0 (Cecropins)
تواريخ الأحداث: Date Created: 20230602 Date Completed: 20230809 Latest Revision: 20230811
رمز التحديث: 20231215
DOI: 10.1016/j.dci.2023.104745
PMID: 37268262
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0089
DOI:10.1016/j.dci.2023.104745