دورية أكاديمية
Exclusion of Horizontal and Vertical Transmission as Major Sources of Trypanosoma Cruzi Infections in a Breeding Colony of Rhesus Macaques ( Macaca Mulatta ).
| العنوان: | Exclusion of Horizontal and Vertical Transmission as Major Sources of Trypanosoma Cruzi Infections in a Breeding Colony of Rhesus Macaques ( Macaca Mulatta ). |
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| المؤلفون: | Kiehl WM; Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas., Hodo CL; MD Anderson Cancer Center, Michale E Keeling Center for Comparative Medicine and Research, Bastrop, Texas; Departments of Veterinary Integrative Biosciences., Hamer GL; Entomology, Texas A&M University, College Station, Texas., Hamer SA; Departments of Veterinary Integrative Biosciences., Wilkerson GK; MD Anderson Cancer Center, Michale E Keeling Center for Comparative Medicine and Research, Bastrop, Texas; Department of Clinal Sciences, North Carolina State University, Raleigh, North Carolina;, Email: Gwilker@ncsu.edu. |
| المصدر: | Comparative medicine [Comp Med] 2023 Jun 01; Vol. 73 (3), pp. 229-241. Date of Electronic Publication: 2023 Jun 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Laboratory Animal Science Country of Publication: United States NLM ID: 100900466 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2769-819X (Electronic) Linking ISSN: 15320820 NLM ISO Abbreviation: Comp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Memphis, TN : American Association for Laboratory Animal Science, 2000- |
| مواضيع طبية MeSH: | Chagas Disease*/epidemiology , Chagas Disease*/veterinary , Trypanosoma cruzi*, Humans ; Animals ; United States ; Macaca mulatta ; Retrospective Studies |
| مستخلص: | The vector-borne protozoal parasite Trypanosoma cruzi causes Chagas disease in humans and animals. This parasite is endemic to the southern United States where outdoor-housed NHP at biomedical facilities are at risk of infection. In addi- tion to the direct morbidity caused by T. cruzi , infected animals are of limited biomedical research use because infections can produce confounding pathophysiologic changes even in animals with no clinical disease. In part due to concerns for direct T. cruzi transmission between animals, infected NHP at some institutions have been culled, removed, or otherwise isolated from uninfected animal populations. However, data that document horizontal or vertical transmission in captive NHP in the United States are not available. To evaluate the potential for inter-animal transmission and to identify environmental factors that affect the distribution of new infections in NHPs, we conducted a retrospective epidemiologic study of a rhesus macaque ( Macaca mulatta ) breeding colony in south Texas. We used archived biologic samples and husbandry records to identify the time and location of macaque seroconversion. These data were used to perform a spatial analysis of how geographic location and animal associations affected the spread of disease and to infer the importance of horizontal or vertical routes of transmission. The majority of T. cruzi infections were spatially clustered, suggesting that environmental factors promoted vector exposure in various areas of the facility. Although we cannot not rule out horizontal transmission, our data suggest that horizontal transmission was not a critical route for spread for the disease. Vertical transmission was not a contributing factor in this colony. In conclusion, our findings suggest that local triatome vectors were the major source of T. cruzi infections in captive macaques in our colony. Therefore, limiting contact with vectors, rather than segregation of infected macaques, is a key strategy for disease prevention at institutions that house macaques outdoors in the southern United States. |
| References: | Acta Trop. 2018 Aug;184:38-52. (PMID: 28941731) PLoS Negl Trop Dis. 2017 Feb 22;11(2):e0005233. (PMID: 28225764) Mem Inst Oswaldo Cruz. 2013;108 Suppl 1:34-47. (PMID: 24473801) Front Public Health. 2019 Jul 02;7:166. (PMID: 31312626) Mem Inst Oswaldo Cruz. 2015 May;110(3):363-8. (PMID: 25760448) Int J Parasitol Parasites Wildl. 2016 Apr 12;5(2):117-23. (PMID: 27330982) Parasitology. 2013 Feb;140(2):147-59. (PMID: 23010131) J Med Entomol. 1970 Jan;7(1):30-45. (PMID: 4907991) J Pediatric Infect Dis Soc. 2019 Nov 6;8(5):461-469. (PMID: 31016324) Rev Soc Bras Med Trop. 2015 Sep-Oct;48(5):532-8. (PMID: 26516961) Am J Trop Med Hyg. 2003 Jun;68(6):683-91. (PMID: 12887027) N Engl J Med. 2015 Jul 30;373(5):456-66. (PMID: 26222561) Int J Infect Dis. 2019 Apr;81:81-84. (PMID: 30664986) Ecohealth. 2018 Jun;15(2):426-436. (PMID: 29497880) Am J Trop Med Hyg. 2009 Aug;81(2):235-9. (PMID: 19635876) J Parasitol. 2007 Feb;93(1):93-6. (PMID: 17436947) Rev Inst Med Trop Sao Paulo. 2021 Jun 18;63:e48. (PMID: 34161554) Am J Trop Med Hyg. 2020 May;102(5):1078-1085. (PMID: 32189615) Mem Inst Oswaldo Cruz. 1990 Apr-Jun;85(2):163-71. (PMID: 2128360) J Med Primatol. 2009 Aug;38(4):247-51. (PMID: 19281482) PLoS Negl Trop Dis. 2021 Mar 31;15(3):e0009141. (PMID: 33788859) Infect Dis Clin North Am. 2012 Jun;26(2):275-91. (PMID: 22632639) Clin Microbiol Rev. 2019 Nov 27;33(1):. (PMID: 31776135) Mem Inst Oswaldo Cruz. 2022 May 16;117:e210033. (PMID: 35584508) Clin Microbiol Rev. 2011 Oct;24(4):655-81. (PMID: 21976603) Acta Trop. 2015 Sep;149:15-8. (PMID: 25982870) ILAR J. 2017 Dec 15;58(3):379-392. (PMID: 29106561) Expert Rev Anti Infect Ther. 2015 Aug;13(8):995-1029. (PMID: 26162928) PLoS Negl Trop Dis. 2020 Dec 17;14(12):e0008932. (PMID: 33332357) J Vector Ecol. 2015 Dec;40(2):379-85. (PMID: 26611974) BMC Infect Dis. 2020 Feb 14;20(1):143. (PMID: 32059706) Trop Med Int Health. 2020 Jul;25(7):752-763. (PMID: 32279399) Lab Anim Sci. 1986 Dec;36(6):667-70. (PMID: 3102852) PLoS Negl Trop Dis. 2015 Dec 10;9(12):e0004235. (PMID: 26658425) Lab Anim Sci. 1974 Oct;24(5):783-7. (PMID: 4370830) Am J Trop Med Hyg. 2003 Feb;68(2):248-52. (PMID: 12641420) Comp Med. 2016 Dec 1;66(6):494-498. (PMID: 28304254) J Am Vet Med Assoc. 1977 Nov 1;171(9):850-4. (PMID: 411770) J Med Entomol. 2018 Oct 25;55(6):1380-1385. (PMID: 29986045) Mem Inst Oswaldo Cruz. 2017 Jun;112(6):437-446. (PMID: 28591404) Curr Opin Infect Dis. 2018 Oct;31(5):415-421. (PMID: 30095485) J Med Primatol. 2008 Feb;37(1):18-25. (PMID: 18199068) Am J Trop Med Hyg. 1982 Sep;31(5):931-3. (PMID: 6812444) Comp Med. 2020 Apr 1;70(2):152-159. (PMID: 32183928) Am J Trop Med Hyg. 2014 Apr;90(4):627-33. (PMID: 24567317) PLoS Negl Trop Dis. 2012;6(5):e1644. (PMID: 22590660) Comp Med. 2014 Aug;64(4):323-8. (PMID: 25296019) Infect Genet Evol. 2018 Mar;58:171-180. (PMID: 29269323) |
| تواريخ الأحداث: | Date Created: 20230602 Date Completed: 20230621 Latest Revision: 20231202 |
| رمز التحديث: | 20231202 |
| مُعرف محوري في PubMed: | PMC10290485 |
| DOI: | 10.30802/AALAS-CM-23-000005 |
| PMID: | 37268411 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2769-819X |
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| DOI: | 10.30802/AALAS-CM-23-000005 |