دورية أكاديمية
أعرض في EDS

Fabrication and optimization of itraconazole-loaded zein-based nanoparticles in coated capsules as a promising colon-targeting approach pursuing opportunistic fungal infections.

التفاصيل البيبلوغرافية
العنوان: Fabrication and optimization of itraconazole-loaded zein-based nanoparticles in coated capsules as a promising colon-targeting approach pursuing opportunistic fungal infections.
المؤلفون: Adel S; Department of Pharmaceutics, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Egypt., Fahmy RH; Department of Pharmaceutics, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Egypt. rania.fahmy@pharma.cu.edu.eg.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt. rania.fahmy@pharma.cu.edu.eg., Elsayed I; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.; Department of Pharmaceutical Sciences, College of Pharmacy and Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab Emirates., Mohamed MI; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt., Ibrahim RR; Department of Pharmaceutics, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Egypt.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Ain Helwan, Egypt.
المصدر: Drug delivery and translational research [Drug Deliv Transl Res] 2023 Dec; Vol. 13 (12), pp. 2982-3002. Date of Electronic Publication: 2023 Jun 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Springer
مواضيع طبية MeSH: Zein* , Nanoparticles*/chemistry , Mycoses*, Humans ; Itraconazole/chemistry ; Antifungal Agents/chemistry ; Spectroscopy, Fourier Transform Infrared ; Colon ; Particle Size
مستخلص: Itraconazole (ITZ), a broad-spectrum antifungal drug, was formulated into colon-targeting system aiming to treat opportunistic colonic fungal infections that commonly infect chronic inflammatory bowel diseases (IBD) patients due to immunosuppressive therapy. Antisolvent precipitation technique was employed to formulate ITZ-loaded zein nanoparticles (ITZ-ZNPs) using various zein: drug and aqueous:organic phase ratios. Central composite face-centered design (CCFD) was used for statistical analysis and optimization. The optimized formulation was composed of 5.5:1 zein:drug ratio and 9.5:1 aqueous:organic phase ratio with its observed particle size, polydispersity index, zeta potential, and entrapment efficiency of 208 ± 4.29 nm, 0.35 ± 0.04, 35.7 ± 1.65 mV, and 66.78 ± 3.89%, respectively. ITZ-ZNPs were imaged by TEM that revealed spherical core-shell structure, and DSC proved ITZ transformation from crystalline to amorphous form. FT-IR showed coupling of zein NH group with ITZ carbonyl group without affecting ITZ antifungal activity as confirmed by antifungal activity test that showed enhanced activity of ITZ-ZNPs over the pure drug. Histopathological examination and cytotoxicity tests ensured biosafety and tolerance of ITZ-ZNPs to the colon tissue. The optimized formulation was then loaded into Eudragit S100-coated capsules and both in vitro release and in vivo X-ray imaging confirmed the success of such coated capsules in protecting ITZ from the release in stomach and intestine while targeting ITZ to the colon. The study proved that ITZ-ZNPs is promising and safe nanoparticulate system that can protect ITZ throughout the GIT and targeting its release to the colon with effectual focused local action for the treatment of colon fungal infections.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Central composite face-centered design (CCFD); Colon fungal infections; Colon targeting; Itraconazole; Zein nanoparticles
المشرفين على المادة: 304NUG5GF4 (Itraconazole)
0 (Antifungal Agents)
9010-66-6 (Zein)
تواريخ الأحداث: Date Created: 20230603 Date Completed: 20231106 Latest Revision: 20231106
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10624751
DOI: 10.1007/s13346-023-01365-0
PMID: 37270444
قاعدة البيانات: MEDLINE
الوصف
تدمد:2190-3948
DOI:10.1007/s13346-023-01365-0