دورية أكاديمية
Deferoxamine Interference in Fibro-inflammation: Additional Action in Control of Obese Adipose Tissue Dysfunction.
| العنوان: | Deferoxamine Interference in Fibro-inflammation: Additional Action in Control of Obese Adipose Tissue Dysfunction. |
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| المؤلفون: | Gotardo EMF; Hematology Center, State University of Campinas, Campinas, SP, Brazil., de Morais TR; Pharmacology Post-graduated Program, State University of Campinas, Campinas, SP, Brazil., Ferreira APT; Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University, Bragança Paulista, SP, Brazil., Caria CREP; Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University, Bragança Paulista, SP, Brazil., Ribeiro ML; Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University, Bragança Paulista, SP, Brazil., Gambero A; Pharmacology Post-graduated Program, State University of Campinas, Campinas, SP, Brazil.; Life Science Center, Pontifical Catholic University of Campinas (PUCCAMP), Campinas, SP, Brazil. |
| المصدر: | Current drug targets [Curr Drug Targets] 2023; Vol. 24 (8), pp. 688-696. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 100960531 Publication Model: Print Cited Medium: Internet ISSN: 1873-5592 (Electronic) Linking ISSN: 13894501 NLM ISO Abbreviation: Curr Drug Targets Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Saif Zone, Sharjah, U. A. E. : Bentham Science Publishers Original Publication: Hilversum, Netherlands ; Boca Raton, FL : Bentham Science Publishers, c2000- |
| مواضيع طبية MeSH: | Deferoxamine*/pharmacology , Deferoxamine*/therapeutic use , Deferoxamine*/metabolism , Insulin Resistance*, Humans ; Animals ; Mice ; Adipose Tissue ; Obesity/metabolism ; Inflammation/metabolism ; Liver/metabolism ; Mice, Inbred C57BL |
| مستخلص: | Introduction: Several studies demonstrated that deferoxamine, an iron chelator, can improve inflammatory alterations in adipose tissue induced by obesity. Obesity alterations in adipose tissue are also associated with tissue remodeling, and deferoxamine has anti-fibrosis action previously described in sites like the skin and liver. Methods: In this work, we analyzed deferoxamine effects on adipose tissue fibro-inflammation during obesity induced by diet in mice. in vitro approaches with fibroblasts and macrophages were also carried out to elucidate deferoxamine activity. Results: Our results demonstrated that in addition to exerting anti-inflammatory effects, reducing the cytokine production in adipose tissue of obese mice and by human monocyte differentiated in macrophage in vitro, deferoxamine can alter metalloproteinases expression and extracellular matrix production in vivo and in vitro . Conclusion: Deferoxamine could be an alternative to control fibro-inflammation in obese adipose tissue, contributing to the metabolic improvements previously described. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Iron chelators; extracellular matrix; fibro-inflammation; fibrosis; metalloproteinase; obesity |
| المشرفين على المادة: | J06Y7MXW4D (Deferoxamine) |
| تواريخ الأحداث: | Date Created: 20230606 Date Completed: 20230829 Latest Revision: 20230902 |
| رمز التحديث: | 20240628 |
| DOI: | 10.2174/1389450124666230602110705 |
| PMID: | 37278033 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1873-5592 |
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| DOI: | 10.2174/1389450124666230602110705 |