دورية أكاديمية
Comparative Venom Multiomics Reveal the Molecular Mechanisms Driving Adaptation to Diverse Predator-Prey Ecosystems in Closely Related Sea Snakes.
العنوان: | Comparative Venom Multiomics Reveal the Molecular Mechanisms Driving Adaptation to Diverse Predator-Prey Ecosystems in Closely Related Sea Snakes. |
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المؤلفون: | Zheng H; Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.; School of Medicine, Shanghai University, Shanghai, China., Wang J; Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China., Fan H; Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China., Wang S; School of Medicine, Shanghai University, Shanghai, China., Ye R; School of Medicine, Shanghai University, Shanghai, China., Li L; School of Medicine, Shanghai University, Shanghai, China., Wang S; Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China., Li A; Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.; Department of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, Shanghai, China., Lu Y; Department of Critical Care Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.; School of Medicine, Shanghai University, Shanghai, China.; Department of Biochemical Pharmacy, School of Pharmacy, Naval Medical University, Shanghai, China. |
المصدر: | Molecular biology and evolution [Mol Biol Evol] 2023 Jun 01; Vol. 40 (6). |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 8501455 Publication Model: Print Cited Medium: Internet ISSN: 1537-1719 (Electronic) Linking ISSN: 07374038 NLM ISO Abbreviation: Mol Biol Evol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2003- : New York, NY : Oxford University Press Original Publication: [Chicago, Ill.] : University of Chicago Press, [c1983- |
مواضيع طبية MeSH: | Hydrophiidae*, Animals ; Phylogeny ; Ecosystem ; Proteomics ; Multiomics ; Elapid Venoms/chemistry ; Elapid Venoms/genetics |
مستخلص: | Predator-prey arms races are ideal models for studying the natural selection and adaptive evolution that drive the formation of biological diversity. For venomous snakes, venom is a key bridge linking snakes with their prey, but whether and how venom evolves under the selection of diet remains unclear. Here, we focused on two closely related sea snakes, Hydrophis cyanocinctus and Hydrophis curtus, which show significant differences in prey preferences. Data-independent acquisition (DIA)-based proteomic analysis revealed different degrees of homogeneity in the venom composition of the two snakes, which was consistent with the differential phylogenetic diversity of their prey. By investigating the sequences and structures of three-finger toxins (3FTx), a predominant toxin family in elapid venom, we identified significant differences between the two sea snakes in the binding activity of 3FTx to receptors from different prey populations, which could explain the trophic specialization of H. cyanocinctus. Furthermore, we performed integrated multiomic profiling of the transcriptomes, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and proteomes of the venom glands; constructed venom-related mRNA-miRNA-lncRNA networks; and identified a series of noncoding RNAs involved in the regulation of toxin gene expression in the two species. These findings are highly informative for elucidating the molecular basis and regulatory mechanisms that account for discrepant venom evolution in response to divergent diets in closely related snakes, providing valuable evidence for the study of coselection and coevolution in predator-prey ecosystems. (© The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.) |
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فهرسة مساهمة: | Keywords: biodiversity; diet divergence; multiomics; ncRNAs; predator–prey |
المشرفين على المادة: | 0 (Elapid Venoms) |
تواريخ الأحداث: | Date Created: 20230606 Date Completed: 20230616 Latest Revision: 20230619 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC10265070 |
DOI: | 10.1093/molbev/msad125 |
PMID: | 37279580 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1537-1719 |
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DOI: | 10.1093/molbev/msad125 |