دورية أكاديمية
Detailed neuropathologic report of COVID-19 complicated by large intracerebral hemorrhage and periventricular lesions with macrophagic infiltrates.
| العنوان: | Detailed neuropathologic report of COVID-19 complicated by large intracerebral hemorrhage and periventricular lesions with macrophagic infiltrates. |
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| المؤلفون: | Levine A; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC Canada., Lee C; Division of Forensic Pathology, Royal Columbian Hospital, Vancouver, BC Canada., Fava C; Division of Critical Care, Royal Columbian Hospital, BC Canada., Tsang F; British Columbia Center for Disease Control, Vancouver, BC Canada., McNeil K; Cancer Genetics & Genomics Laboratory, BC Cancer, Vancouver, BC Canada., Yip ST; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC Canada.; Cancer Genetics & Genomics Laboratory, BC Cancer, Vancouver, BC Canada., Hirsch-Reinshagen V; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC Canada. |
| المصدر: | Free neuropathology [Free Neuropathol] 2021 Mar 25; Vol. 2. Date of Electronic Publication: 2021 Mar 25 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: University of Muenster Country of Publication: Germany NLM ID: 101768755 Publication Model: eCollection Cited Medium: Internet ISSN: 2699-4445 (Electronic) Linking ISSN: 26994445 NLM ISO Abbreviation: Free Neuropathol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Muenster, Germany : University of Muenster, [2020]- |
| مستخلص: | Infection with the SARS-CoV-2 virus affects a wide range of systems. Significant involvement of the central nervous system has been described, including ischemic and hemorrhagic strokes. Thus far, neuropathologic reports of patients who passed away from COVID-19 have generally described non-specific findings, such as variable reactive gliosis and meningeal chronic inflammatory infiltrates, as well as the consequences of the infection's systemic complications on the brain, including ischemic infarcts and hypoxic/ischemic encephalopathy. The neuropathological changes in patients with COVID-19 and large hemorrhagic strokes have not been described in detail. We report the case of an elderly male who had a long course of COVID-19 and ultimately passed away from a large intracerebral hemorrhage. In addition to acute hemorrhage, neuropathologic examination demonstrated non-specific reactive changes and chronic periventricular lesions with macrophagic and perivascular lymphocytic infiltrates without evidence of demyelination or presence of SARS-CoV-2 by PCR test. This manuscript expands the spectrum of reported neuropathological changes in patients with COVID-19. |
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| فهرسة مساهمة: | Keywords: Brain; COVID-19; Cerebral hemorrhage; Histology; Neuropathology; Postmortem |
| تواريخ الأحداث: | Date Created: 20230607 Latest Revision: 20230608 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10209866 |
| DOI: | 10.17879/freeneuropathology-2021-3266 |
| PMID: | 37284618 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2699-4445 |
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| DOI: | 10.17879/freeneuropathology-2021-3266 |