دورية أكاديمية
Circulating miR-26b-5p and miR-451a as diagnostic biomarkers in medullary thyroid carcinoma patients.
| العنوان: | Circulating miR-26b-5p and miR-451a as diagnostic biomarkers in medullary thyroid carcinoma patients. |
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| المؤلفون: | Besharat ZM; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy., Trocchianesi S; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Verrienti A; Department of Translational and Precision Medicine, Sapienza University of Rome, 00161, Rome, Italy., Ciampi R; Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126, Pisa, Italy., Cantara S; Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100, Siena, Italy., Romei C; Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126, Pisa, Italy., Sabato C; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy., Noviello TMR; Biogem Scarl, Istituto di Ricerche Genetiche 'Gaetano Salvatore', 83031, Ariano Irpino, Italy.; Department of Electrical Engineering and Information Technology, University of Naples Federico II, 80138, Naples, Italy., Po A; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Citarella A; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy., Caruso FP; Biogem Scarl, Istituto di Ricerche Genetiche 'Gaetano Salvatore', 83031, Ariano Irpino, Italy.; Department of Electrical Engineering and Information Technology, University of Naples Federico II, 80138, Naples, Italy., Panariello I; Thyroid Surgical Unit, IRCCS Fondazione G.Pascale, 80131, Naples, Italy., Gianno F; Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, 00161, Rome, Italy., Carpino G; Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy., Gaudio E; Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy., Chiacchiarini M; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy., Masuelli L; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy., Sponziello M; Department of Translational and Precision Medicine, Sapienza University of Rome, 00161, Rome, Italy., Pecce V; Department of Translational and Precision Medicine, Sapienza University of Rome, 00161, Rome, Italy., Ramone T; Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126, Pisa, Italy., Maino F; Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100, Siena, Italy., Dotta F; Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100, Siena, Italy.; Tuscany Centre for Precision Medicine (CReMeP), 53100, Siena, Italy., Ceccarelli M; Biogem Scarl, Istituto di Ricerche Genetiche 'Gaetano Salvatore', 83031, Ariano Irpino, Italy.; Department of Electrical Engineering and Information Technology, University of Naples Federico II, 80138, Naples, Italy., Pezzullo L; Thyroid Surgical Unit, IRCCS Fondazione G.Pascale, 80131, Naples, Italy., Durante C; Department of Translational and Precision Medicine, Sapienza University of Rome, 00161, Rome, Italy. cosimo.durante@uniroma1.it., Castagna MG; Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100, Siena, Italy., Elisei R; Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126, Pisa, Italy., Ferretti E; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy. elisabetta.ferretti@uniroma1.it. |
| المصدر: | Journal of endocrinological investigation [J Endocrinol Invest] 2023 Dec; Vol. 46 (12), pp. 2583-2599. Date of Electronic Publication: 2023 Jun 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Berlin : Springer Original Publication: Milano, Published for the Italian Society of Endocrinology by Editrice Kurtis. |
| مواضيع طبية MeSH: | MicroRNAs*/genetics , Thyroid Neoplasms*/diagnosis , Thyroid Neoplasms*/genetics , Thyroid Neoplasms*/pathology , Circulating MicroRNA*, Humans ; Biomarkers ; Biomarkers, Tumor/metabolism |
| مستخلص: | Purpose/methods: The determination of tumour biomarkers is paramount to advancing personalized medicine, more so in rare tumours like medullary thyroid carcinoma (MTC), whose diagnosis is still challenging. The aim of this study was to identify non-invasive circulating biomarkers in MTC. To achieve this goal, paired MTC tissue and plasma extracellular vesicle samples were collected from multiple centres and microRNA (miRNA) expression levels were evaluated. Results: The samples from a discovery cohort of 23 MTC patients were analysed using miRNA arrays. Lasso logistic regression analysis resulted in the identification of a set of circulating miRNAs as diagnostic biomarkers. Among them, miR-26b-5p and miR-451a, were highly expressed and their expression decreased during follow-up in disease-free patients in the discovery cohort. Circulating miR-26b-5p and miR-451a were validated using droplet digital PCR in a second independent cohort of 12 MTC patients. Conclusion: This study allowed the identification and validation of a signature of two circulating miRNAs, miR-26b-5p and miR-451a, in two independent cohorts reporting a significant diagnostic performance for MTC. The results of this study offer advancements in molecular diagnosis of MTC proposing a novel non-invasive tool to use in precision medicine. (© 2023. The Author(s).) |
| التعليقات: | Erratum in: J Endocrinol Invest. 2023 Aug 10;:. (PMID: 37563447) |
| References: | Nat Rev Drug Discov. 2013 May;12(5):347-57. (PMID: 23584393) Curr Opin Oncol. 2013 Jan;25(1):66-75. (PMID: 23165142) Int J Mol Sci. 2017 Dec 17;18(12):. (PMID: 29258209) Endocr Connect. 2021 Apr 26;10(4):447-461. (PMID: 33764887) JAMA. 1996 Nov 20;276(19):1575-9. (PMID: 8918855) J Mol Endocrinol. 2009 Oct;43(4):143-55. (PMID: 19383830) Nature. 1994 Jan 27;367(6461):375-6. (PMID: 7906866) Pharmacol Ther. 2021 Mar;219:107708. (PMID: 33091426) Nat Cell Biol. 2015 Jun;17(6):816-26. (PMID: 25985394) Nucleic Acids Res. 2015 Jul 1;43(W1):W460-6. (PMID: 25977294) Mol Biol Rep. 2022 Mar;49(3):1955-1971. (PMID: 34993725) Endocr Relat Cancer. 2018 Mar;25(3):217-231. (PMID: 29298817) J Cell Mol Med. 2020 Jul;24(14):7730-7742. (PMID: 32476275) Am J Surg Pathol. 1998 Jun;22(6):722-8. (PMID: 9630179) J Transl Med. 2022 Oct 15;20(1):469. (PMID: 36243798) Dis Markers. 2019 Sep 16;2019:3717683. (PMID: 31636734) Medicina (Kaunas). 2021 Jun 11;57(6):. (PMID: 34208296) Nat Rev Drug Discov. 2017 Mar;16(3):203-222. (PMID: 28209991) Acta Clin Croat. 2020 Jun;59(Suppl 1):50-59. (PMID: 34219884) Clinics (Sao Paulo). 2009;64(7):699-706. (PMID: 19606248) Cancers (Basel). 2020 Feb 14;12(2):. (PMID: 32075127) Ann Oncol. 2013 Sep;24(9):2256-61. (PMID: 23676418) Nature. 2015 Nov 19;527(7578):329-35. (PMID: 26524530) Pathol Res Pract. 2021 Jun;222:153458. (PMID: 33962174) Methods. 2013 Jan;59(1):S1-6. (PMID: 23036329) PLoS One. 2017 Dec 6;12(12):e0189165. (PMID: 29211799) Ann Oncol. 2019 Dec 1;30(12):1856-1883. (PMID: 31549998) Hematol Oncol. 2022 Apr;40(2):172-180. (PMID: 34874565) J Cell Physiol. 2020 Feb;235(2):1366-1373. (PMID: 31297834) Cancer Lett. 2022 Aug 10;541:215746. (PMID: 35594995) Nature. 2004 Sep 16;431(7006):350-5. (PMID: 15372042) Int J Biol Markers. 2022 Mar;37(1):74-80. (PMID: 35001683) Lancet Diabetes Endocrinol. 2016 Jan;4(1):64-71. (PMID: 26608066) Front Genet. 2013 May 24;4:94. (PMID: 23745127) Annu Rev Med. 2009;60:167-79. (PMID: 19630570) Bioinformatics. 2009 Dec 15;25(24):3325-6. (PMID: 19808880) Cells. 2020 Jan 23;9(2):. (PMID: 31979244) |
| معلومات مُعتمدة: | TRS-2016-00001141 Agenzia Italiana del Farmaco, Ministero della Salute; Sapienza Research Grant Ateneo 2018 Sapienza Università di Roma |
| فهرسة مساهمة: | Keywords: Diagnostic biomarkers; Liquid biopsy; Medullary thyroid carcinoma; Plasma extracellular miRNAs/circulating miRNAs; miR-26b-5p; miR-451a |
| المشرفين على المادة: | 0 (MicroRNAs) 0 (Circulating MicroRNA) 0 (Biomarkers) 0 (Biomarkers, Tumor) |
| SCR Disease Name: | Thyroid cancer, medullary |
| تواريخ الأحداث: | Date Created: 20230607 Date Completed: 20231110 Latest Revision: 20240211 |
| رمز التحديث: | 20240212 |
| مُعرف محوري في PubMed: | PMC10632281 |
| DOI: | 10.1007/s40618-023-02115-2 |
| PMID: | 37286863 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1720-8386 |
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| DOI: | 10.1007/s40618-023-02115-2 |