دورية أكاديمية
Evolving landscape of carbapenem-resistant Pseudomonas aeruginosa at a single centre in the USA.
| العنوان: | Evolving landscape of carbapenem-resistant Pseudomonas aeruginosa at a single centre in the USA. |
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| المؤلفون: | Sakurai A; Department of Infectious Diseases and Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan., Dinh AQ; Department of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.; Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX, USA.; Center for Infectious Diseases, University of Texas Health Science Center, School of Public Health, Houston, TX, USA., Hanson BM; Center for Infectious Diseases, University of Texas Health Science Center, School of Public Health, Houston, TX, USA.; Center for Antimicrobial Resistance and Microbial Genomics, University of Texas Health Science Center, McGovern Medical School, Houston, TX, USA., Shropshire WC; Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA., Rizvi SA; Department of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.; Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX, USA., Rydell K; Department of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.; Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX, USA., Tran TT; Department of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.; Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX, USA., Wanger A; Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, McGovern School of Medicine, Houston, TX, USA., Arias CA; Department of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.; Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX, USA., Miller WR; Department of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.; Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX, USA. |
| المصدر: | JAC-antimicrobial resistance [JAC Antimicrob Resist] 2023 Jun 03; Vol. 5 (3), pp. dlad070. Date of Electronic Publication: 2023 Jun 03 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101765283 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-1823 (Electronic) Linking ISSN: 26321823 NLM ISO Abbreviation: JAC Antimicrob Resist Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford] : Oxford University Press, [2019]- |
| مستخلص: | Objectives: The increased identification of carbapenem-resistant Pseudomonas aeruginosa (CR-PA) is an ongoing concern. However, information on the evolving antimicrobial resistance profile and molecular epidemiology of CR-PA over time is scarce. Thus, we conducted a cross-sectional analysis to investigate the phenotypic and genotypic characteristics of CR-PA recovered over different time periods, focusing on the isolates exhibiting a ceftolozane/tazobactam resistance phenotype. Methods: A total of 169 CR-PA isolated from clinical specimens at a single centre in Houston, TX, USA were studied. Among them, 61 isolates collected between 1999 and 2005 were defined as historical strains, and 108 collected between 2017 and 2018 were defined as contemporary strains. Antimicrobial susceptibilities against selected β-lactams was determined. WGS data were used for the identification of antimicrobial resistance determinants and phylogenetic analysis. Results: Non-susceptibility to ceftolozane/tazobactam and ceftazidime/avibactam increased from 2% (1/59) to 17% (18/108) and from 7% (4/59) to 17% (18/108) from the historical to the contemporary collection, respectively. Carbapenemase genes, which were not identified in the historical collection, were harboured by 4.6% (5/108) of the contemporary strains, and the prevalence of ESBL genes also increased from 3.3% (2/61) to 16% (17/108). Genes encoding acquired β-lactamases were largely confined to the high-risk clones. Among ceftolozane/tazobactam-resistant isolates, non-susceptibility to ceftazidime/avibactam, imipenem/relebactam and cefiderocol was observed in 94% (15/16), 56% (9/16) and 12.5% (2/16), respectively. Resistance to ceftolozane/tazobactam and imipenem/relebactam was primarily associated with the presence of exogenous β-lactamases. Conclusions: Acquisition of exogenous carbapenemases and ESBLs may be a worrisome trend in P. aeruginosa . (© The Author(s) 2023. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.) |
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| معلومات مُعتمدة: | K08 AI135093 United States AI NIAID NIH HHS; K24 AI121296 United States AI NIAID NIH HHS |
| تواريخ الأحداث: | Date Created: 20230608 Latest Revision: 20230711 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10243771 |
| DOI: | 10.1093/jacamr/dlad070 |
| PMID: | 37288080 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2632-1823 |
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| DOI: | 10.1093/jacamr/dlad070 |