دورية أكاديمية
In silico analysis of the different variable domain oriented single-chain variable fragment antibody-antigen complexes.
العنوان: | In silico analysis of the different variable domain oriented single-chain variable fragment antibody-antigen complexes. |
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المؤلفون: | Koçer İ; Department of Chemical Engineering, Hacettepe University, Ankara, Turkey.; Institute of Science, Hacettepe University, Ankara, Turkey., Çelik E; Department of Chemical Engineering, Hacettepe University, Ankara, Turkey.; Institute of Science, Division of Bioengineering, Hacettepe University, Ankara, Turkey. |
المصدر: | Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 Jun; Vol. 42 (9), pp. 4699-4709. Date of Electronic Publication: 2023 Jun 08. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE |
أسماء مطبوعة: | Publication: June 2012- : Oxon, UK : Taylor & Francis Original Publication: Guilderland, NY : Adenine Press, [c1983- |
مواضيع طبية MeSH: | Single-Chain Antibodies*/chemistry , Single-Chain Antibodies*/immunology , Molecular Dynamics Simulation* , Receptor, ErbB-2*/immunology , Receptor, ErbB-2*/chemistry , Antigen-Antibody Complex*/chemistry , Antigen-Antibody Complex*/immunology , Protein Binding*, Humans ; Computer Simulation ; Interleukin-1beta/immunology ; Interleukin-1beta/chemistry ; Interleukin-1beta/metabolism ; Thermodynamics |
مستخلص: | Single-chain variable fragment (scFv) antibodies hold great potential as diagnostic tools and therapeutic agents, especially for tumor cells. Since these applications require their production with improved properties, the design strategy of scFvs is crucial for their active, soluble, and high yield expression with high affinity towards their antigens. The order of V |
فهرسة مساهمة: | Keywords: Binding free energy; GROMACS; MD simulation; VL/VH orientation; scFv |
تواريخ الأحداث: | Date Created: 20230608 Date Completed: 20240515 Latest Revision: 20240515 |
رمز التحديث: | 20240515 |
DOI: | 10.1080/07391102.2023.2222191 |
PMID: | 37288797 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1538-0254 |
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DOI: | 10.1080/07391102.2023.2222191 |