Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study.

التفاصيل البيبلوغرافية
العنوان:	Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study.
المؤلفون:	Brzezinski KW; IRIS group, IFIC, Parque Científico, Catedrático José Beltrán, 2, Paterna, Valencia, 46071, SPAIN., Baran J; Institute of Nuclear Physics Polish Academy of Sciences, Radzikowskiego 152, Cracow, 31-342, POLAND., Borys D; Institute of Automatic Control, Silesian University of Technology, ul. Akademicka 16, Gliwice, 44-100, POLAND., Gajewski J; Institute of Nuclear Physics Polish Academy of Science, Radzikowskiego 152, Krakow, Krakow, Malopolska, 31-342, POLAND., Chug N; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Krakow, 30-348, POLAND., Coussat A; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Krakow, Małopolskie, 30-348, POLAND., Czerwiński E; Institute of Physics, Jagiellonian University, Łojasiewicza 11, Cracow, 30-348, POLAND., Dadgar M; Medical physics, Urmia University of Medical Sciences, No 11, Daneshgah, Urmia, Urmia, West Azarbayjan, +98, Iran (the Islamic Republic of)., Dulski K; Institute of Physics, Jagiellonian University, Łojasiewicza 11, Cracow, 30-348, POLAND., Eliyan KV; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Krakow, Małopolskie, 30-348, POLAND., Gajos A; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Krakow, Małopolskie, 30-348, POLAND., Kacprzak K; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Kraków, 30-348, POLAND., Kapłon Ł; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University in Krakow, Lojasiewicza 11, Krakow, Malopolskie, 31-007, POLAND., Klimaszewski K; Narodowe Centrum Badan Jadrowych, 7 Andrzeja Sołtana, Otwock, 05-400, POLAND., Konieczka P; Department of Complex Systems, National Centre for Nuclear Research, 7 Andrzeja Sołtana str., Otwock, 05-400, POLAND., Kopec R; Institute of Nuclear Physics Polish Academy of Science, Radzikowskiego 152, Krakow, 31-342, POLAND., Korcyl G; Institute of Physics, Jagiellonian University, Łojasiewicza 11, Cracow, 30-348, POLAND., Kozik T; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Krakow, Małopolskie, 30-348, POLAND., Krzemień W; National Centre for Nuclear Research, 7 Andrzeja Sołtana, Warsaw, 05-400, POLAND., Kumar D; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Krakow, Małopolskie, 30-348, POLAND., Lomax AJ; Department of Radiation Medicine, Paul Scherrer Institute, Villigen PSI, Villigen, CH-5232 , SWITZERLAND., McNamara K; Center for Proton Therapy, Paul Scherrer Institute PSI, Forschungsstrasse 111, Villigen, Aargau, 5232, SWITZERLAND., Niedźwiecki S; Institute of Physics, Jagiellonian University, Łojasiewicza 11, Cracow, 30-348, POLAND., Olko P; PAN, Polish Academy of Sciences, ul Radzikowskiego 152, Krakow, Kraków, 31-342, POLAND., Panek D; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Krakow, Małopolskie, 30-348, POLAND., Parzych S; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Kraków, 30-348, POLAND., Perez Del Rio E; Sapienza University of Rome, Piazzale Aldo Moro, 5, Roma, Lazio, 00185, ITALY., Raczyński L; National Centre for Nuclear Research, 7 Andrzeja Sołtana, Warsaw, 05-400, POLAND., Sharma S; Uniwersytet Jagiellonski w Krakowie Wydzial Fizyki Astronomii i Informatyki Stosowanej, Łojasiewicza 11, Krakow, 30-348, POLAND., Shivani S; Uniwersytet Jagiellonski w Krakowie Wydzial Fizyki Astronomii i Informatyki Stosowanej, Łojasiewicza 11, Krakow, 30-348, POLAND., Shopa RY; Narodowe Centrum Badan Jadrowych, 7 Andrzeja Sołtana, Otwock, 05-400, POLAND., Skóra T; Krakow Branch, Department of Oncology, Maria Sklodowska-CurieMemorial Cancer Centre and Institute of Oncology, ul. Garncarska 11, Krakow, 31-115, POLAND., Skurzok M; UJ Marian Smoluchowski Institute of Physics, Uniwersytet Jagiellonski w Krakowie Wydzial Fizyki Astronomii i Informatyki Stosowanej, Łojasiewicza 11, Krakow, 30-348, POLAND., Stasica P; Institute of Nuclear Physics Polish Academy of Science, Radzikowskiego 152, Krakow, PL 31-342, POLAND., Stępień EL; UJ Marian Smoluchowski Institute of Physics, Uniwersytet Jagiellonski w Krakowie Wydzial Fizyki Astronomii i Informatyki Stosowanej, Łojasiewicza 11, Krakow, 30-348, POLAND., Tayefi Ardebili K; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Krakow, Małopolskie, 30-348, POLAND., Tayefi F; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Kraków, 30-348, POLAND., Weber DC; Center for Proton Therapy, Paul Scherrer Institute, PSI, Villigen, CH-5232 , SWITZERLAND., Winterhalter C; Paul Scherrer Institut, PSI, Villigen, 5232, SWITZERLAND., Wiślicki W; National Centre for Nuclear Research, 7 Andrzeja Sołtana, Warsaw, 05-400, POLAND., Moskal P; Jagiellonian University in Krakow Faculty of Physics Astronomy and Applied Computer Science, Łojasiewicza 11, Krakow, 30-348, POLAND., Rucinski A; Institute of Nuclear Physics PAS, Radzikowskiego 152, Krakow, 31-342, POLAND.
المصدر:	Physics in medicine and biology [Phys Med Biol] 2023 Jun 09. Date of Electronic Publication: 2023 Jun 09.
Publication Model:	Ahead of Print
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Bristol : IOP Publishing
مستخلص:	Objective: The Jagiellonian PET (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach: Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualised in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results: Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r^2 = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance: The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment. . (Creative Commons Attribution license.)
فهرسة مساهمة:	Keywords: J-PET; Monte Carlo; in vivo range verification; positron emission tomography; proton therapy
تواريخ الأحداث:	Date Created: 20230609 Latest Revision: 20230609
رمز التحديث:	20231215
DOI:	10.1088/1361-6560/acdd4c
PMID:	37295440
قاعدة البيانات:	MEDLINE

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تدمد:	1361-6560
DOI:	10.1088/1361-6560/acdd4c