دورية أكاديمية
أعرض في EDS

Indole Propionic Acid Increases T Regulatory Cells and Decreases T Helper 17 Cells and Blood Pressure in Mice with Salt-Sensitive Hypertension.

التفاصيل البيبلوغرافية
العنوان: Indole Propionic Acid Increases T Regulatory Cells and Decreases T Helper 17 Cells and Blood Pressure in Mice with Salt-Sensitive Hypertension.
المؤلفون: Baranwal G; Department of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX 77807, USA., Goodlett BL; Department of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX 77807, USA., Arenaz CM; Department of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX 77807, USA., Creed HA; Department of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX 77807, USA., Navaneethabalakrishnan S; Department of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX 77807, USA., Rutkowski JM; Department of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX 77807, USA., Alaniz RC; Department of Microbial Pathogenesis and Immunology, Texas A&M University School of Medicine, Bryan, TX 77807, USA., Mitchell BM; Department of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX 77807, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 May 24; Vol. 24 (11). Date of Electronic Publication: 2023 May 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Cardiovascular Diseases*/metabolism , Hypertension*/metabolism, Animals ; Mice ; Th17 Cells/metabolism ; Blood Pressure ; T-Lymphocytes, Regulatory/metabolism ; Tryptophan/metabolism ; Sodium Chloride/pharmacology ; Sodium Chloride, Dietary/metabolism ; Indoles/metabolism ; Sodium/metabolism
مستخلص: Hypertension affects over a billion adults worldwide and is a major risk factor for cardiovascular disease. Studies have reported that the microbiota and its metabolites regulate hypertension pathophysiology. Recently, tryptophan metabolites have been identified to contribute to and inhibit the progression of metabolic disorders and cardiovascular diseases, including hypertension. Indole propionic acid (IPA) is a tryptophan metabolite with reported protective effects in neurodegenerative and cardiovascular diseases; however, its involvement in renal immunomodulation and sodium handling in hypertension is unknown. In the current study, targeted metabolomic analysis revealed decreased serum and fecal IPA levels in mice with L-arginine methyl ester hydrochloride (L-NAME)/high salt diet-induced hypertension (LSHTN) compared to normotensive control mice. Additionally, kidneys from LSHTN mice had increased T helper 17 (Th17) cells and decreased T regulatory (Treg) cells. Dietary IPA supplementation in LSHTN mice for 3 weeks resulted in decreased systolic blood pressure, along with increased total 24 h and fractional sodium excretion. Kidney immunophenotyping demonstrated decreased Th17 cells and a trend toward increased Treg cells in IPA-supplemented LSHTN mice. In vitro, naïve T cells from control mice were skewed into Th17 or Treg cells. The presence of IPA decreased Th17 cells and increased Treg cells after 3 days. These results identify a direct role for IPA in attenuating renal Th17 cells and increasing Treg cells, leading to improved sodium handling and decreased blood pressure. IPA may be a potential metabolite-based therapeutic option for hypertension.
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معلومات مُعتمدة: P30 DK079328 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Th17; Treg; hypertension; immunity; kidney; microbiome
المشرفين على المادة: 8DUH1N11BX (Tryptophan)
JHU490RVYR (propionic acid)
451W47IQ8X (Sodium Chloride)
0 (Sodium Chloride, Dietary)
0 (Indoles)
9NEZ333N27 (Sodium)
تواريخ الأحداث: Date Created: 20230610 Date Completed: 20230612 Latest Revision: 20230919
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10252743
DOI: 10.3390/ijms24119192
PMID: 37298145
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms24119192