دورية أكاديمية
أعرض في EDS

TREX1 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals.

التفاصيل البيبلوغرافية
العنوان: TREX1 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals.
المؤلفون: Queiroz MAF; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Moura TCF; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Bichara CDA; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Lima LLP; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Oliveira AQT; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Souza RG; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Gomes STM; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Amoras EDSG; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Vallinoto ACR; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 02; Vol. 24 (11). Date of Electronic Publication: 2023 Jun 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: HIV Infections*/drug therapy , HIV Infections*/genetics , HIV-1*/genetics , Exodeoxyribonucleases*/genetics , Exodeoxyribonucleases*/immunology, Humans ; Antibodies, Antinuclear ; Autoantibodies ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Cross-Sectional Studies ; Polymorphism, Genetic
مستخلص: Autoimmune diseases can develop during HIV-1 infection, mainly related to the individual's immune competence. The study investigated the association of the TREX1 531C/T polymorphism and antinuclear antibodies (ANA) in HIV-1 infection and the time of antiretroviral therapy (ART) used. Cross-sectional and longitudinal assessments were carried out in 150 individuals, divided into three groups: ART-naïve, 5 years and 10 years on ART; ART-naïve individuals were evaluated for 2 years after initiation of treatment. The individuals' blood samples were submitted to indirect immunofluorescence tests, real-time PCR and flow cytometry. The TREX1 531C/T polymorphism was associated with higher levels of TCD4 + lymphocytes and IFN-α in individuals with HIV-1. Individuals on ART had a higher frequency of ANA, higher levels of T CD4 + lymphocytes, a higher ratio of T CD4 + /CD8 + lymphocytes and higher levels of IFN-α than therapy-naïve individuals ( p < 0.05). The TREX1 531C/T polymorphism was associated with better maintenance of the immune status of individuals with HIV-1 and ANA with immune restoration in individuals on ART, indicating the need to identify individuals at risk of developing an autoimmune disease.
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معلومات مُعتمدة: (#302935/2021-5 - ACRV; #304835/2022 - MAFQ National Council for Scientific and Technological Development; FAPESPA/CNPq/PRONEX-060/2020 Fundação Amazônia Paraense de Amparo a Estudos e Pesquisas; PAPQ/2023 Federal University of Para
فهرسة مساهمة: Keywords: ART; HIV-1; TREX-1; autoantibodies; polymorphism
المشرفين على المادة: 0 (Antibodies, Antinuclear)
0 (Autoantibodies)
EC 3.1.16.- (three prime repair exonuclease 1)
EC 3.1.- (Exodeoxyribonucleases)
تواريخ الأحداث: Date Created: 20230610 Date Completed: 20230615 Latest Revision: 20230615
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10253649
DOI: 10.3390/ijms24119660
PMID: 37298611
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms24119660