دورية أكاديمية
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Injectable, Antibacterial, and Hemostatic Tissue Sealant Hydrogels.

التفاصيل البيبلوغرافية
العنوان: Injectable, Antibacterial, and Hemostatic Tissue Sealant Hydrogels.
المؤلفون: Haghniaz R; Terasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA.; Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, USA., Montazerian H; Terasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA.; Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, USA., Rabbani A; Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, USA.; Akhtar Saeed Medical College, Bahria Golf City, 46000, Pakistan., Baidya A; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603203, India., Usui B; Terasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA.; Franklin W. Olin College of Engineering, 1000 Olin Way, Needham, MA, 02492, USA., Zhu Y; Terasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA., Tavafoghi M; Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA.; California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, USA., Wahid F; Department of Biomedical Sciences, Pak-Austria Fachhochschule, Institute of Applied Sciences and Technology, Haripur, 22620, Pakistan., Kim HJ; Terasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA.; College of Pharmacy, Korea University, Sejong, 30019, Republic of Korea., Sheikhi A; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA., Khademhosseini A; Terasaki Institute for Biomedical Innovation, 11570 W Olympic Blvd, Los Angeles, CA, 90024, USA.
المصدر: Advanced healthcare materials [Adv Healthc Mater] 2023 Dec; Vol. 12 (31), pp. e2301551. Date of Electronic Publication: 2023 Jul 10.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim : Wiley-VCH, 2012-
مواضيع طبية MeSH: Hydrogels*/pharmacology , Hemostatics*/pharmacology, Rats ; Swine ; Animals ; Hemostasis ; Anti-Bacterial Agents/pharmacology ; Silicates/pharmacology
مستخلص: Hemorrhage and bacterial infections are major hurdles in the management of life-threatening surgical wounds. Most bioadhesives for wound closure lack sufficient hemostatic and antibacterial properties. Furthermore, they suffer from weak sealing efficacy, particularly for stretchable organs, such as the lung and bladder. Accordingly, there is an unmet need for mechanically robust hemostatic sealants with simultaneous antibacterial effects. Here, an injectable, photocrosslinkable, and stretchable hydrogel sealant based on gelatin methacryloyl (GelMA), supplemented with antibacterial zinc ferrite (ZF) nanoparticles and hemostatic silicate nanoplatelets (SNs) for rapid blood coagulation is nanoengineered. The hydrogel reduces the in vitro viability of Staphylococcus aureus by more than 90%. The addition of SNs (2% w/v) and ZF nanoparticles (1.5 mg mL -1 ) to GelMA (20% w/v) improves the burst pressure of perforated ex vivo porcine lungs by more than 40%. Such enhancement translated to ≈250% improvement in the tissue sealing capability compared with a commercial hemostatic sealant, Evicel. Furthermore, the hydrogels reduce bleeding by ≈50% in rat bleeding models. The nanoengineered hydrogel may open new translational opportunities for the effective sealing of complex wounds that require mechanical flexibility, infection management, and hemostasis.
(© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.)
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معلومات مُعتمدة: 1R01EB023052 United States NH NIH HHS; R01 CA257558 United States CA NCI NIH HHS; DK130566 United States NH NIH HHS; R01 EB023052 United States EB NIBIB NIH HHS; R01 DK130566 United States DK NIDDK NIH HHS; R01 HL140618 United States HL NHLBI NIH HHS; 1R01HL140618 United States NH NIH HHS; CA257558 United States NH NIH HHS; 1R01EB023052 United States NH NIH HHS; 1R01HL140618 United States NH NIH HHS; CA257558 United States NH NIH HHS; DK130566 United States NH NIH HHS
فهرسة مساهمة: Keywords: antimicrobial hemostats; bioadhesives; bleeding wounds; hydrogels; sealants
المشرفين على المادة: 0 (Hydrogels)
0 (Hemostatics)
0 (Anti-Bacterial Agents)
0 (Silicates)
تواريخ الأحداث: Date Created: 20230610 Date Completed: 20231216 Latest Revision: 20240627
رمز التحديث: 20240627
مُعرف محوري في PubMed: PMC10710521
DOI: 10.1002/adhm.202301551
PMID: 37300448
قاعدة البيانات: MEDLINE
الوصف
تدمد:2192-2659
DOI:10.1002/adhm.202301551