دورية أكاديمية
Impact of Initiating Biologics in Patients With Severe Asthma on Long-Term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry.
| العنوان: | Impact of Initiating Biologics in Patients With Severe Asthma on Long-Term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry. |
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| المؤلفون: | Chen W; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Tran TN; AstraZeneca, Gaithersburg, Md., Sadatsafavi M; Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada., Murray R; Optimum Patient Care Global, Cambridge, United Kingdom., Wong NCB; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Ali N; Optimum Patient Care Global, Cambridge, United Kingdom; Observational and Pragmatic Research Institute, Singapore., Ariti C; Optimum Patient Care Global, Cambridge, United Kingdom; Observational and Pragmatic Research Institute, Singapore., Bulathsinhala L; Optimum Patient Care Global, Cambridge, United Kingdom; Observational and Pragmatic Research Institute, Singapore., Gil EG; AstraZeneca, Barcelona, Spain., FitzGerald JM; Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada., Alacqua M; AstraZeneca, Cambridge, United Kingdom., Al-Ahmad M; Microbiology Department, Faculty of Medicine, Kuwait University, Al-Rashed Allergy Center, Ministry of Health, Kuwait City, Kuwait., Altraja A; Department of Pulmonology, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, Estonia., Al-Lehebi R; Department of Pulmonology, King Fahad Medical City, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Bhutani M; Division of Pulmonary Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada., Bjermer L; Respiratory Medicine and Allergology, Department of Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden., Bjerrum AS; Department of Respiratory Medicine and Allergy, Aarhus University Hospital, Aarhus, Denmark., Bourdin A; PhyMedExp, Univ Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France., von Bülow A; Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark., Busby J; Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland., Canonica GW; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Carter V; Optimum Patient Care Global, Cambridge, United Kingdom; Observational and Pragmatic Research Institute, Singapore., Christoff GC; Faculty of Public Health, Medical University-Sofia, Sofia, Bulgaria., Cosio BG; Son Espases University Hospital-IdISBa-Ciberes, Mallorca, Spain., Costello RW; Department of Respiratory Medicine, RCSI Clinical Research Centre, Smurfit Building Beaumont Hospital, Dublin, Ireland., Fonseca JA; Health Information and Decision Sciences Department (MEDCIDS) & Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine of University of Porto, Porto, Portugal., Gibson PG; Australian Severe Asthma Network, Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South Wales, Australia; Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton Heights, New South Wales, Australia., Yoo KH; KonKuk University School of Medicine, Seoul, Korea., Heaney LG; Wellcome-Wolfson Centre for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland., Heffler E; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Hew M; Allergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, Victoria, Australia; Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Hilberg O; Medical Department, Vejle University Hospital, Vejle, Denmark., Hoyte F; Division of Allergy & Clinical Immunology, Department of Medicine, National Jewish Health, Denver, Colo; Division of Allergy & Clinical Immunology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., Iwanaga T; Center for General Medical Education and Clinical Training, Kindai University Hospital, Osakasayama, Japan., Jackson DJ; UK Severe Asthma Network and National Registry, Guy's and St Thomas' NHS Trust, London, United Kingdom; School of Immunology & Microbial Sciences, King's College London, London, United Kingdom., Jones RC; Research and Knowledge Exchange, Plymouth Marjon University, Plymouth, United Kingdom., Koh MS; Respiratory & Critical Care Medicine, Singapore General Hospital, Singapore; SingHealth Duke-NUS Lung Centre, Singapore., Kuna P; Division of Internal Medicine, Asthma and Allergy Medical University of Łódź, Łódź, Poland., Larenas-Linnemann D; Centro de Excelencia en Asma y Alergia, Hospital Médica Sur, Mexico City, Mexico., Lehmann S; Section of Thoracic Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway., Lehtimäki L; Allergy Centre, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Lyu J; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care, Brisbane, Queensland, Australia., Mahboub B; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates., Maspero J; Clinical Research for Allergy and Respiratory Medicine, CIDEA Foundation, Buenos Aires, Argentina; University Career of Specialists in Allergy and Clinical Immunology at the Buenos Aires University School of Medicine, Buenos Aires, Argentina., Menzies-Gow AN; Royal Brompton & Harefield Hospitals, London, United Kingdom., Newell A; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care, Brisbane, Queensland, Australia., Sirena C; Severe Asthma Network in Italy (SANI), Milan, Italy., Papadopoulos NG; Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece., Papaioannou AI; 2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, Greece., Perez-de-Llano L; Pneumology Service, Lucus Augusti University Hospital, EOXI Lugo, Monforte, Cervo, Lugo, Spain; Biodiscovery Research Group, Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain., Perng Steve DW; Division of Clinical Respiratory Physiology, Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan; COPD Assembly of the Asian Pacific Society of Respirology, Tokyo, Japan., Peters M; Department of Thoracic Medicine, Concord Hospital, Sydney, New South Wales, Australia., Pfeffer PE; Department of Respiratory Medicine, Barts Health NHS Trust, London, United Kingdom; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Porsbjerg CM; Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark., Popov TA; University Hospital 'Sv. Ivan Rilski,' Sofia, Bulgaria., Rhee CK; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea., Salvi S; Pulmocare Research and Education Foundation, Pune, Maharashtra, India., Taillé C; Department of Respiratory Diseases, Bichat Hospital, AP-HP Nord-Université de Paris, Paris, France., Taube C; Department of Pulmonary Medicine, University Medical Center Essen-Ruhrlandklinik, Essen, Germany., Torres-Duque CA; CINEUMO, Respiratory Research Center, Fundación Neumológica Colombiana, Bogotá, Colombia., Ulrik C; Department of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark., Ra SW; Division of Pulmonology, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea., Wang E; Division of Allergy & Clinical Immunology, Department of Medicine, National Jewish Health, Denver, Colo; Division of Allergy & Clinical Immunology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., Wechsler ME; NJH Cohen Family Asthma Institute, Department of Medicine, National Jewish Health, Denver, Colo., Price DB; Optimum Patient Care Global, Cambridge, United Kingdom; Observational and Pragmatic Research Institute, Singapore; Division of Applied Health Sciences, Centre of Academic Primary Care, University of Aberdeen, Aberdeen, United Kingdom. Electronic address: dprice@opri.sg. |
| المصدر: | The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2023 Sep; Vol. 11 (9), pp. 2732-2747. Date of Electronic Publication: 2023 Jun 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101597220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2201 (Electronic) NLM ISO Abbreviation: J Allergy Clin Immunol Pract Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier Inc., [2013]- |
| مواضيع طبية MeSH: | Asthma*/drug therapy , Asthma*/epidemiology , Asthma*/chemically induced , Biological Products*/therapeutic use , Anti-Asthmatic Agents*/therapeutic use, Adult ; Humans ; Prospective Studies ; Adrenal Cortex Hormones/therapeutic use ; Steroids/therapeutic use |
| مستخلص: | Background: Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS) nor been compared with effectiveness of continuing with HOCS alone. Objective: To examine the effectiveness of initiating biologics in a large, real-world cohort of adult patients with severe asthma and HOCS. Methods: This was a propensity score-matched, prospective cohort study using data from the International Severe Asthma Registry. Between January 2015 and February 2021, patients with severe asthma and HOCS (long-term OCSs for ≥1 year or ≥4 courses of rescue OCSs within a 12-month period) were identified. Biologic initiators were identified and, using propensity scores, matched 1:1 with noninitiators. The impact of biologic initiation on asthma outcomes was assessed using generalized linear models. Results: We identified 996 matched pairs of patients. Both groups improved over the 12-month follow-up period, but improvement was greater for biologic initiators. Biologic initiation was associated with a 72.9% reduction in the average number of exacerbations per year versus noninitiators (0.64 vs 2.06; rate ratio, 0.27 [95% CI, 0.10-0.71]). Biologic initiators were 2.2 times more likely than noninitiators to take a daily long-term OCS dose of less than 5 mg (risk probability, 49.6% vs 22.5%; P = .002) and had a lower risk of asthma-related emergency department visits (relative risk, 0.35 [95% CI, 0.21-0.58]; rate ratio, 0.26 [0.14-0.48]) and hospitalizations (relative risk, 0.31 [95% CI, 0.18-0.52]; rate ratio, 0.25 [0.13-0.48]). Conclusions: In a real-world setting, including patients with severe asthma and HOCS from 19 countries, and within an environment of clinical improvement, initiation of biologics was associated with further improvements across multiple asthma outcomes, including exacerbation rate, OCS exposure, and health care resource utilization. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: J Allergy Clin Immunol Pract. 2024 Feb;12(2):535-536. (PMID: 38336402) |
| فهرسة مساهمة: | Keywords: Biologics; Effectiveness; ISAR; Oral corticosteroids; Real life |
| المشرفين على المادة: | 0 (Adrenal Cortex Hormones) 0 (Steroids) 0 (Biological Products) 0 (Anti-Asthmatic Agents) |
| تواريخ الأحداث: | Date Created: 20230610 Date Completed: 20230911 Latest Revision: 20240223 |
| رمز التحديث: | 20240223 |
| DOI: | 10.1016/j.jaip.2023.05.044 |
| PMID: | 37301430 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 2213-2201 |
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| DOI: | 10.1016/j.jaip.2023.05.044 |