دورية أكاديمية
أعرض في EDS

The aflatoxin B 1 -induced imidazole ring-opened guanine adduct: High mutagenic potential that is minimally affected by sequence context.

التفاصيل البيبلوغرافية
العنوان: The aflatoxin B 1 -induced imidazole ring-opened guanine adduct: High mutagenic potential that is minimally affected by sequence context.
المؤلفون: Minko IG; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, Oregon, USA., Kellum AH Jr; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA., Stone MP; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA., Lloyd RS; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, Oregon, USA.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, USA.
المصدر: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2024 Apr; Vol. 65 Suppl 1, pp. 9-13. Date of Electronic Publication: 2023 Jun 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2280 (Electronic) Linking ISSN: 08936692 NLM ISO Abbreviation: Environ Mol Mutagen Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Wiley-Liss
Original Publication: New York, NY : Liss, c1987-
مواضيع طبية MeSH: Mutagens*/toxicity , Liver Neoplasms*/pathology, Animals ; Aflatoxin B1/toxicity ; DNA Adducts/genetics ; Guanine ; Mutagenesis ; Imidazoles/adverse effects
مستخلص: Dietary exposure to aflatoxin B 1 (AFB 1 ) is a recognized risk factor for developing hepatocellular carcinoma. The mutational signature of AFB 1 is characterized by high-frequency base substitutions, predominantly G>T transversions, in a limited subset of trinucleotide sequences. The 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxyaflatoxin B 1 (AFB 1 -FapyGua) has been implicated as the primary DNA lesion responsible for AFB 1 -induced mutations. This study evaluated the mutagenic potential of AFB 1 -FapyGua in four sequence contexts, including hot- and cold-spot sequences as apparent in the mutational signature. Vectors containing site-specific AFB 1 -FapyGua lesions were replicated in primate cells and the products of replication were isolated and sequenced. Consistent with the role of AFB 1 -FapyGua in AFB 1 -induced mutagenesis, AFB 1 -FapyGua was highly mutagenic in all four sequence contexts, causing G>T transversions and other base substitutions at frequencies of ~80%-90%. These data suggest that the unique mutational signature of AFB 1 is not explained by sequence-dependent fidelity of replication past AFB 1 -FapyGua lesions.
(© 2023 Environmental Mutagenesis and Genomics Society.)
References: Genome Res. 2017 Sep;27(9):1475-1486. (PMID: 28739859)
Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3101-E3109. (PMID: 28351974)
Gastroenterology. 2017 Jul;153(1):249-262.e2. (PMID: 28363643)
Genes Dev. 2002 Aug 1;16(15):1872-83. (PMID: 12154119)
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13774-13779. (PMID: 27849610)
Nature. 1991 Apr 4;350(6317):429-31. (PMID: 1672732)
J Biol Chem. 2017 Nov 17;292(46):18790-18799. (PMID: 28972137)
Int J Environ Res Public Health. 2020 Feb 13;17(4):. (PMID: 32070028)
Cancer Res. 1981 Jan;41(1):197-203. (PMID: 7448760)
Nat Commun. 2020 May 1;11(1):2169. (PMID: 32358516)
Chem Res Toxicol. 2021 Mar 15;34(3):901-911. (PMID: 33595290)
Cell. 2019 May 2;177(4):821-836.e16. (PMID: 30982602)
J Am Chem Soc. 2009 Nov 11;131(44):16096-107. (PMID: 19831353)
DNA Repair (Amst). 2019 May;77:76-86. (PMID: 30897375)
Nature. 1991 Apr 4;350(6317):427-8. (PMID: 1849234)
Oncogene. 1998 Dec 10;17(23):3007-14. (PMID: 9881702)
DNA Repair (Amst). 2018 Nov;71:12-22. (PMID: 30309820)
Nature. 2020 Feb;578(7793):94-101. (PMID: 32025018)
Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4207-4212. (PMID: 28373545)
Chem Res Toxicol. 2015 Feb 16;28(2):225-37. (PMID: 25587868)
Toxicol Sci. 2011 Mar;120 Suppl 1:S28-48. (PMID: 20881231)
Chem Res Toxicol. 2019 Jan 22;32(1):80-89. (PMID: 30525498)
Foods. 2022 Sep 13;11(18):. (PMID: 36140952)
Carcinogenesis. 2014 Jul;35(7):1461-8. (PMID: 24398669)
معلومات مُعتمدة: P30CA-068485 United States CA NCI NIH HHS; P01 CA160032 United States CA NCI NIH HHS; R01CA-55678 United States CA NCI NIH HHS; R01 ES031086 United States ES NIEHS NIH HHS; R01 ES-029357 United States ES NIEHS NIH HHS; P30 CA068485 United States CA NCI NIH HHS; R01 CA055678 United States CA NCI NIH HHS; R01 ES-031086 United States ES NIEHS NIH HHS; R01 ES029357 United States ES NIEHS NIH HHS; P30CA-068485 United States CA NCI NIH HHS; R01CA-55678 United States CA NCI NIH HHS; R01 ES-029357 United States ES NIEHS NIH HHS; R01 ES-031086 United States ES NIEHS NIH HHS
فهرسة مساهمة: Keywords: COSMIC signature SBS24; base substitution; hepatocellular carcinoma; replication bypass
المشرفين على المادة: 0 (Mutagens)
9N2N2Y55MH (Aflatoxin B1)
0 (DNA Adducts)
5Z93L87A1R (Guanine)
0 (Imidazoles)
تواريخ الأحداث: Date Created: 20230612 Date Completed: 20240417 Latest Revision: 20240426
رمز التحديث: 20240426
مُعرف محوري في PubMed: PMC10711146
DOI: 10.1002/em.22556
PMID: 37303259
قاعدة البيانات: MEDLINE
الوصف
تدمد:1098-2280
DOI:10.1002/em.22556