دورية أكاديمية
Chromogenic enzyme substrates based on [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives for the detection of nitroreductase activity in clinically important microorganisms.
| العنوان: | Chromogenic enzyme substrates based on [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives for the detection of nitroreductase activity in clinically important microorganisms. |
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| المؤلفون: | Cellier-Rastit M; Research & Development Microbiology, bioMérieux SA, 3 route de Port Michaud, La-Balme-les-Grottes 38 390, France., Chalansonnet V; Research & Development Microbiology, bioMérieux SA, 3 route de Port Michaud, La-Balme-les-Grottes 38 390, France., James AL; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK. steven.stanforth@northumbria.ac.uk., Johnston A; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK. steven.stanforth@northumbria.ac.uk., Orenga S; Research & Development Microbiology, bioMérieux SA, 3 route de Port Michaud, La-Balme-les-Grottes 38 390, France., Perry JD; Department of Microbiology, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK., Roger-Dalbert C; Research & Development Microbiology, bioMérieux SA, 3 route de Port Michaud, La-Balme-les-Grottes 38 390, France., Salwatura VL; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK. steven.stanforth@northumbria.ac.uk., Stanforth SP; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK. steven.stanforth@northumbria.ac.uk., Sykes HE; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK. steven.stanforth@northumbria.ac.uk., Truong VT; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK. steven.stanforth@northumbria.ac.uk., Turnbull G; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK. steven.stanforth@northumbria.ac.uk. |
| المصدر: | Journal of materials chemistry. B [J Mater Chem B] 2023 Jul 05; Vol. 11 (26), pp. 6106-6113. Date of Electronic Publication: 2023 Jul 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-7518 (Electronic) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Chromogenic Compounds*/chemistry , Nitroreductases*/metabolism, Substrate Specificity |
| مستخلص: | A series of [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives have been synthesised as potential indicators of microbial nitroreductase activity. When assessed against a selection of 20 clinically important pathogenic microorganisms, microbial colonies of various colours (yellow, green, red, brown, black) were produced and attributed to nitroreductase activity. Most substrates elicited colour responses with Gram-negative microorganisms. In contrast, the growth of several species of Gram-positive microorganisms and yeasts was often inhibited by the substrates and hence coloured responses were not seen. |
| المشرفين على المادة: | 0 (Chromogenic Compounds) EC 1.7.- (Nitroreductases) |
| تواريخ الأحداث: | Date Created: 20230612 Date Completed: 20230707 Latest Revision: 20230718 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1039/d3tb00715d |
| PMID: | 37306765 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2050-7518 |
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| DOI: | 10.1039/d3tb00715d |