دورية أكاديمية
أعرض في EDS

Potential from synergistic effect of quercetin and paclitaxel co-encapsulated in the targeted folic-gelatin-pluronic P123 nanogels for chemotherapy.

التفاصيل البيبلوغرافية
العنوان: Potential from synergistic effect of quercetin and paclitaxel co-encapsulated in the targeted folic-gelatin-pluronic P123 nanogels for chemotherapy.
المؤلفون: Nguyen DT; Graduate University of Science and Technology, VAST, TL29, Thanh Loc ward, Dist. 12, HCMC, Viet Nam; Institute of Applied Materials Science, VAST, TL29, Thanh Loc ward, Dist. 12, HCMC, Viet Nam., Nguyen TP; Faculty of Chemical Technology, HCMC University of Food Industry, Ho Chi Minh City 700000, Viet Nam., Dinh VT; Graduate University of Science and Technology, VAST, TL29, Thanh Loc ward, Dist. 12, HCMC, Viet Nam., Nguyen NH; Institute of Applied Materials Science, VAST, TL29, Thanh Loc ward, Dist. 12, HCMC, Viet Nam., Nguyen KTH; Institute of Applied Materials Science, VAST, TL29, Thanh Loc ward, Dist. 12, HCMC, Viet Nam., Nguyen TH; Vietnam Department of Tissue Engineering and Regenerative Medicine, School of Biomedical Engineering, International University, Vietnam National University, Ho Chi Minh City (VNU-HCM) 700000, Viet Nam., Ngan TT; Vietnam Department of Tissue Engineering and Regenerative Medicine, School of Biomedical Engineering, International University, Vietnam National University, Ho Chi Minh City (VNU-HCM) 700000, Viet Nam., Nhi TTY; Institute of Technology Application and Sustainable Development, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Viet Nam., Le BHT; University of Science - Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam., Le Thi P; Graduate University of Science and Technology, VAST, TL29, Thanh Loc ward, Dist. 12, HCMC, Viet Nam; Institute of Applied Materials Science, VAST, TL29, Thanh Loc ward, Dist. 12, HCMC, Viet Nam. Electronic address: ltphuong@iams.vast.vn., Dang LH; Graduate University of Science and Technology, VAST, TL29, Thanh Loc ward, Dist. 12, HCMC, Viet Nam; Institute of Applied Materials Science, VAST, TL29, Thanh Loc ward, Dist. 12, HCMC, Viet Nam. Electronic address: dtlhang@iams.vast.vn., Tran NQ; Graduate University of Science and Technology, VAST, TL29, Thanh Loc ward, Dist. 12, HCMC, Viet Nam; Institute of Applied Materials Science, VAST, TL29, Thanh Loc ward, Dist. 12, HCMC, Viet Nam. Electronic address: tnquyen@iams.vast.vn.
المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2023 Jul 15; Vol. 243, pp. 125248. Date of Electronic Publication: 2023 Jun 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Guildford, Eng., IPC Science and Technology Press.
مواضيع طبية MeSH: Paclitaxel*/pharmacology , Paclitaxel*/therapeutic use , Gelatin*/pharmacology, Mice ; Animals ; Quercetin/pharmacology ; Nanogels ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Drug Delivery Systems/methods ; Micelles ; Folic Acid/pharmacology ; Drug Carriers/pharmacology
مستخلص: Dual-drug delivery systems for anticancer therapy have recently attracted substantial attention due to their potency to overcome limitations of conventional anti-cancer drugs, tackle drug resistance problems, as well as improve the therapeutic efficacy. In this study, we introduced a novel nanogel based on folic acid-gelatin-pluronic P123 (FA-GP-P123) conjugate to simultaneously deliver quercetin (QU) and paclitaxel (PTX) to the targeted tumor. The results indicated that the drug loading capacity of FA-GP-P123 nanogels was significantly higher than that of P123 micelles. The kinetic release profiles of QU and PTX from the nanocarriers were governed by Fickian diffusion and swelling behavior, respectively. Notably, FA-GP-P123/QU/PTX dual-drug delivery system induced higher toxicity to MCF-7 and Hela cancer cells than either QU or PTX individual delivery system, and the non-targeted dug delivery system (GP-P123/QU/PTX), indicating the synergistic combination of dual drugs and FA positive targeting effect. Furthermore, FA-GP-P123 could effectively deliver QU and PTX to tumors in vivo after administration into MCF-7 tumor-bearing mice, which resulted in 94.20 ± 5.90 % of tumor volume reduced at day 14. Moreover, the side effects of the dual-drug delivery system were significantly reduced. Overall, we suggest FA-GP-P123 as potential nanocarrier for dual-drug delivery for targeted chemotherapy.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Dual drug delivery; Paclitaxel; Quercetin
المشرفين على المادة: P88XT4IS4D (Paclitaxel)
2E9U4Y94DB (pluronic block copolymer P123)
9000-70-8 (Gelatin)
9IKM0I5T1E (Quercetin)
0 (Nanogels)
0 (Micelles)
935E97BOY8 (Folic Acid)
0 (Drug Carriers)
تواريخ الأحداث: Date Created: 20230612 Date Completed: 20230619 Latest Revision: 20230619
رمز التحديث: 20231215
DOI: 10.1016/j.ijbiomac.2023.125248
PMID: 37307971
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0003
DOI:10.1016/j.ijbiomac.2023.125248