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Does Vestibular Motion Perception Correlate with Axonal Pathways Stimulated by Subthalamic Deep Brain Stimulation in Parkinson's Disease?

التفاصيل البيبلوغرافية
العنوان: Does Vestibular Motion Perception Correlate with Axonal Pathways Stimulated by Subthalamic Deep Brain Stimulation in Parkinson's Disease?
المؤلفون: Beylergil SB; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; National VA Parkinson Consortium Center, Neurology Service, Daroff-Dell'Osso Ocular Motility and Vestibular Laboratory, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA., Noecker AM; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA., Kilbane C; Department of Neurology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, 44110, USA.; Movement Disorders Center, Neurological Institute, University Hospitals, Cleveland, OH, USA., McIntyre CC; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA., Shaikh AG; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA. aasefshaikh@gmail.com.; National VA Parkinson Consortium Center, Neurology Service, Daroff-Dell'Osso Ocular Motility and Vestibular Laboratory, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA. aasefshaikh@gmail.com.; Department of Neurology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, 44110, USA. aasefshaikh@gmail.com.; Movement Disorders Center, Neurological Institute, University Hospitals, Cleveland, OH, USA. aasefshaikh@gmail.com.
المصدر: Cerebellum (London, England) [Cerebellum] 2024 Apr; Vol. 23 (2), pp. 554-569. Date of Electronic Publication: 2023 Jun 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101089443 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-4230 (Electronic) Linking ISSN: 14734222 NLM ISO Abbreviation: Cerebellum Subsets: MEDLINE
أسماء مطبوعة: Publication: <2006->: New York : Springer
Original Publication: London : Martin Dunitz, c2002-
مواضيع طبية MeSH: Parkinson Disease*/therapy , Deep Brain Stimulation*/methods , Motion Perception* , Subthalamic Nucleus*/physiology, Humans ; Thalamus
مستخلص: Perception of our linear motion - heading - is critical for postural control, gait, and locomotion, and it is impaired in Parkinson's disease (PD). Deep brain stimulation (DBS) has variable effects on vestibular heading perception, depending on the location of the electrodes within the subthalamic nucleus (STN). Here, we aimed to find the anatomical correlates of heading perception in PD. Fourteen PD participants with bilateral STN DBS performed a two-alternative forced-choice discrimination task where a motion platform delivered translational forward movements with a heading angle varying between 0 and 30° to the left or to the right with respect to the straight-ahead direction. Using psychometric curves, we derived the heading discrimination threshold angle of each patient from the response data. We created patient-specific DBS models and calculated the percentages of stimulated axonal pathways that are anatomically adjacent to the STN and known to play a major role in vestibular information processing. We performed correlation analyses to investigate the extent of these white matter tracts' involvement in heading perception. Significant positive correlations were identified between improved heading discrimination for rightward heading and the percentage of activated streamlines of the contralateral hyperdirect, pallido-subthalamic, and subthalamo-pallidal pathways. The hyperdirect pathways are thought to provide top-down control over STN connections to the cerebellum. In addition, STN may also antidromically activate collaterals of hyperdirect pathway that projects to the precerebellar pontine nuclei. In select cases, there was strong activation of the cerebello-thalamic projections, but it was not consistently present in all participants. Large volumetric overlap between the volume of tissue activation and the STN in the left hemisphere positively impacted rightward heading perception. Altogether, the results suggest heavy involvement of basal ganglia cerebellar network in STN-induced modulation of vestibular heading perception in PD.
(© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
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معلومات مُعتمدة: CX002086-03 Department of Veterans Affairs CSRD Merit review; Geroge C. Cotzias Memorial Fellowship American Parkinson's Disease Association; Career Development Award American Academy of Neurology; Community Partnership Caresource Ohio
فهرسة مساهمة: Keywords: Basal ganglia; Cerebellum; Motion-perception; Movement disorders; Neurodegeneration; Parkinsonism
تواريخ الأحداث: Date Created: 20230612 Date Completed: 20240320 Latest Revision: 20240320
رمز التحديث: 20240320
DOI: 10.1007/s12311-023-01576-8
PMID: 37308757
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-4230
DOI:10.1007/s12311-023-01576-8