دورية أكاديمية
أعرض في EDS

An ultrasound-based radiomics model for survival prediction in patients with endometrial cancer.

التفاصيل البيبلوغرافية
العنوان: An ultrasound-based radiomics model for survival prediction in patients with endometrial cancer.
المؤلفون: Huang XW; Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China., Ding J; Department of Ultrasound Imaging, Yueqing Hospital of Wenzhou Medical University, Wenzhou, 325015, People's Republic of China., Zheng RR; Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China., Ma JY; Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China., Cai MT; Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China., Powell M; Nottingham Treatment Centre, Nottingham University Affiliated Hospital, Nottingham, NG7 2FT, UK., Lin F; Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China., Yang YJ; Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China., Jin C; Wenzhou Medical University Renji College, University Town, Chashan, Wenzhou, 325000, People's Republic of China. jinchu20222022@163.com.
المصدر: Journal of medical ultrasonics (2001) [J Med Ultrason (2001)] 2023 Oct; Vol. 50 (4), pp. 501-510. Date of Electronic Publication: 2023 Jun 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Japan NLM ID: 101128385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-2254 (Electronic) Linking ISSN: 13464523 NLM ISO Abbreviation: J Med Ultrason (2001) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Tokyo, Japan : Springer Verlag, c2001-
مواضيع طبية MeSH: Endometrial Neoplasms*/diagnostic imaging, Humans ; Female ; Ultrasonography ; Nomograms
مستخلص: Purpose: To establish a nomogram integrating radiomics features based on ultrasound images and clinical parameters for predicting the prognosis of patients with endometrial cancer (EC).
Materials and Methods: A total of 175 eligible patients with ECs were enrolled in our study between January 2011 and April 2018. They were divided into a training cohort (n = 122) and a validation cohort (n = 53). Least absolute shrinkage and selection operator (LASSO) regression were applied for selection of key features, and a radiomics score (rad-score) was calculated. Patients were stratified into high risk and low-risk groups according to the rad-score. Univariate and multivariable COX regression analysis was used to select independent clinical parameters for disease-free survival (DFS). A combined model based on radiomics features and clinical parameters was ultimately established, and the performance was quantified with respect to discrimination and calibration.
Results: Nine features were selected from 1130 features using LASSO regression in the training cohort, which yielded an area under the curve (AUC) of 0.823 and 0.792 to predict DFS in the training and validation cohorts, respectively. Patients with a higher rad-score were significantly associated with worse DFS. The combined nomogram, which was composed of clinically significant variables and radiomics features, showed a calibration and favorable performance for DFS prediction (AUC 0.893 and 0.885 in the training and validation cohorts, respectively).
Conclusion: The combined nomogram could be used as a tool in predicting DFS and may assist individualized decision making and clinical treatment.
(© 2023. The Author(s), under exclusive licence to The Japan Society of Ultrasonics in Medicine.)
التعليقات: Erratum in: J Med Ultrason (2001). 2024 Mar 21;:. (PMID: 38512526)
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معلومات مُعتمدة: 81803781 Project of China Natural Science Foundation; LQ18H280007 Project of Zhejiang Provincial Natural Science Foundation; Y20220397 Wenzhou Science and Technology Bureau
فهرسة مساهمة: Keywords: Disease-free survival; Endometrial cancer; Nomogram; Radiomics features; Ultrasound
تواريخ الأحداث: Date Created: 20230613 Date Completed: 20231023 Latest Revision: 20240323
رمز التحديث: 20240323
مُعرف محوري في PubMed: PMC10955020
DOI: 10.1007/s10396-023-01331-w
PMID: 37310510
قاعدة البيانات: MEDLINE
الوصف
تدمد:1613-2254
DOI:10.1007/s10396-023-01331-w