دورية أكاديمية
أعرض في EDS

A DFT study of the gallium ion-binding capacity of mature Pseudomonas aeruginosa biofilm extracellular polysaccharide.

التفاصيل البيبلوغرافية
العنوان: A DFT study of the gallium ion-binding capacity of mature Pseudomonas aeruginosa biofilm extracellular polysaccharide.
المؤلفون: Hills OJ; School of Food Science & Nutrition, University of Leeds, Woodhouse Lane, Leeds, United Kingdom., Poskrobko Z; School of Food Science & Nutrition, University of Leeds, Woodhouse Lane, Leeds, United Kingdom., Scott AJ; School of Chemical & Process Engineering, University of Leeds, Woodhouse Lane, Leeds, United Kingdom., Smith J; School of Food Science & Nutrition, University of Leeds, Woodhouse Lane, Leeds, United Kingdom., Chappell HF; School of Food Science & Nutrition, University of Leeds, Woodhouse Lane, Leeds, United Kingdom.
المصدر: PloS one [PLoS One] 2023 Jun 14; Vol. 18 (6), pp. e0287191. Date of Electronic Publication: 2023 Jun 14 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Cystic Fibrosis* , Gallium*/pharmacology, Humans ; Pseudomonas aeruginosa ; Calcium ; Siderophores/pharmacology ; Polysaccharides ; Biofilms
مستخلص: Intravenous gallium therapy is a non-antibiotic approach to limit Pseudomonas aeruginosa biofilm proliferation, by outcompeting iron for siderophore binding. Gallium therapy represents a viable therapeutic strategy for cystic fibrosis (CF) patients harbouring mucoid P. aeruginosa biofilm lung infections. Siderophore deficient P. aeruginosa isolates still demonstrate a hindered biofilm proliferation when exposed to gallium but it is currently unknown whether exogenous gallium has any disruptive influence on the exopolysaccharide (EPS), the major mucoid P. aeruginosa CF lung biofilm matrix component. To that end, Density-Functional Theory (DFT) was deployed to assess whether gallium (Ga3+) could be substituted into the mature mucoid EPS scaffold in preference of calcium (Ca2+)-the native EPS cross-linking ion. Removal of the stable, bound native calcium ions offers a large enthalpic barrier to the substitution and the mature EPS fails to accommodate exogenous gallium. This suggests that gallium, perhaps, is utilising a novel, possibly unknown, ferric uptake system to gain entry to siderophore deficient cells.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Hills et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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المشرفين على المادة: SY7Q814VUP (Calcium)
0 (Siderophores)
0 (Polysaccharides)
CH46OC8YV4 (Gallium)
تواريخ الأحداث: Date Created: 20230614 Date Completed: 20230616 Latest Revision: 20230621
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10266685
DOI: 10.1371/journal.pone.0287191
PMID: 37315081
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0287191