دورية أكاديمية
The cofactor challenge in synthetic methylotrophy: bioengineering and industrial applications.
العنوان: | The cofactor challenge in synthetic methylotrophy: bioengineering and industrial applications. |
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المؤلفون: | Krüsemann JL; Charité - Universitätsmedizin Berlin, Department of Biochemistry, Charitéplatz 1, 10117 Berlin, Germany; Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam, Germany; Max Planck Institute for Terrestrial Microbiology, Department of Biochemistry and Synthetic Metabolism, Karl-von-Frisch-Str. 10, 35043 Marburg, Germany., Rainaldi V; Laboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands., Cotton CA; Cambrium GmbH, Max-Urich-Straße 3, 13355 Berlin, Germany., Claassens NJ; Laboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands., Lindner SN; Charité - Universitätsmedizin Berlin, Department of Biochemistry, Charitéplatz 1, 10117 Berlin, Germany; Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam, Germany. Electronic address: steffen.lindner@charite.de. |
المصدر: | Current opinion in biotechnology [Curr Opin Biotechnol] 2023 Aug; Vol. 82, pp. 102953. Date of Electronic Publication: 2023 Jun 13. |
نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9100492 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0429 (Electronic) Linking ISSN: 09581669 NLM ISO Abbreviation: Curr Opin Biotechnol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: London : Elsevier Original Publication: London : Current Biology, c1990- |
مواضيع طبية MeSH: | NAD* , Methanol*, Hydrogen Peroxide ; PQQ Cofactor ; Bioengineering |
مستخلص: | Methanol is a promising feedstock for industrial bioproduction: it can be produced renewably and has high solubility and limited microbial toxicity. One of the key challenges for its bio-industrial application is the first enzymatic oxidation step to formaldehyde. This reaction is catalysed by methanol dehydrogenases (MDH) that can use NAD + , O Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest. (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
المشرفين على المادة: | 0U46U6E8UK (NAD) Y4S76JWI15 (Methanol) BBX060AN9V (Hydrogen Peroxide) 72909-34-3 (PQQ Cofactor) |
تواريخ الأحداث: | Date Created: 20230615 Date Completed: 20230802 Latest Revision: 20230806 |
رمز التحديث: | 20231215 |
DOI: | 10.1016/j.copbio.2023.102953 |
PMID: | 37320962 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1879-0429 |
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DOI: | 10.1016/j.copbio.2023.102953 |