دورية أكاديمية
Spectrochemical analysis of blood combined with chemometric techniques for detecting osteosarcopenia.
العنوان: | Spectrochemical analysis of blood combined with chemometric techniques for detecting osteosarcopenia. |
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المؤلفون: | da Silva TG; Institute of Chemistry, Biological Chemistry and Chemometrics, Federal University of Rio Grande do Norte, Natal, 59075-970, Brazil., Morais CLM; Institute of Chemistry, Biological Chemistry and Chemometrics, Federal University of Rio Grande do Norte, Natal, 59075-970, Brazil., Santos MCD; Institute of Chemistry, Biological Chemistry and Chemometrics, Federal University of Rio Grande do Norte, Natal, 59075-970, Brazil.; Federal Institute of Education, Science and Technology of Sertão Pernambucano, Floresta, 56400-000, Brazil., de Lima LAS; Estácio de Sá Goiás, North Regional, Goiânia, GO, 74063-010, Brazil., de Medeiros Freitas RV; Postgraduation Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, 59075-970, Brazil., Guerra RO; Postgraduation Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, 59075-970, Brazil.; Postgraduation Program in Physiotherapy, Federal University of Rio Grande do Norte, Natal, 59075-970, Brazil.; Department of Physiotherapy, Federal University of Rio Grande do Norte, Natal, 59075-970, Brazil., Lima KMG; Institute of Chemistry, Biological Chemistry and Chemometrics, Federal University of Rio Grande do Norte, Natal, 59075-970, Brazil. kassio.lima@ufrn.br. |
المصدر: | Scientific reports [Sci Rep] 2023 Jun 15; Vol. 13 (1), pp. 9686. Date of Electronic Publication: 2023 Jun 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Chemometrics* , Support Vector Machine*, Humans ; Female ; Aged ; Spectrophotometry, Infrared ; Principal Component Analysis ; Discriminant Analysis |
مستخلص: | Among several complications related to physiotherapy, osteosarcopenia is one of the most frequent in elderly patients. This condition is limiting and quite harmful to the patient's health by disabling several basic musculoskeletal activities. Currently, the test to identify this health condition is complex. In this study, we use mid-infrared spectroscopy combined with chemometric techniques to identify osteosarcopenia based on blood serum samples. The purpose of this study was to evaluate the mid-infrared spectroscopy power to detect osteosarcopenia in community-dwelling older women (n = 62, 30 from patients with osteosarcopenia and 32 healthy controls). Feature reduction and selection techniques were employed in conjunction with discriminant analysis, where a principal component analysis with support vector machines (PCA-SVM) model achieved 89% accuracy to distinguish the samples from patients with osteosarcopenia. This study shows the potential of using infrared spectroscopy of blood samples to identify osteosarcopenia in a simple, fast and objective way. (© 2023. The Author(s).) |
References: | Nat Protoc. 2020 Jul;15(7):2143-2162. (PMID: 32555465) J Am Med Dir Assoc. 2011 May;12(4):249-56. (PMID: 21527165) Trends Analyt Chem. 2017 Dec;97:244-256. (PMID: 32287542) Age Ageing. 2019 Jan 1;48(1):16-31. (PMID: 30312372) Sci Rep. 2020 Jul 16;10(1):11769. (PMID: 32678231) BMC Womens Health. 2022 May 14;22(1):171. (PMID: 35568898) Sci Rep. 2020 Jul 30;10(1):12818. (PMID: 32733086) Anal Bioanal Chem. 2018 Jul;410(18):4541-4554. (PMID: 29740671) Eur J Clin Nutr. 2016 Sep;70(9):1046-51. (PMID: 27167668) Curr Osteoporos Rep. 2014 Jun;12(2):142-53. (PMID: 24633910) Nat Protoc. 2010 Nov;5(11):1748-60. (PMID: 21030951) Sci Rep. 2020 Nov 6;10(1):19259. (PMID: 33159100) Nat Protoc. 2014 Aug;9(8):1771-91. (PMID: 24992094) Int J Mol Sci. 2022 May 17;23(10):. (PMID: 35628399) Analyst. 2018 Apr 16;143(8):1735-1757. (PMID: 29504623) Nat Protoc. 2019 May;14(5):1546-1577. (PMID: 30953040) Calcif Tissue Int. 2023 Feb;112(2):197-217. (PMID: 36633611) Br J Hosp Med (Lond). 2018 May 2;79(5):253-258. (PMID: 29727228) Analyst. 2016 Aug 2;141(16):4833-47. (PMID: 27433557) |
تواريخ الأحداث: | Date Created: 20230615 Date Completed: 20230619 Latest Revision: 20231121 |
رمز التحديث: | 20231122 |
مُعرف محوري في PubMed: | PMC10272198 |
DOI: | 10.1038/s41598-023-36834-6 |
PMID: | 37322087 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-023-36834-6 |