دورية أكاديمية
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Which Moiety Drives Gangliosides to Form Nanodomains?

التفاصيل البيبلوغرافية
العنوان: Which Moiety Drives Gangliosides to Form Nanodomains?
المؤلفون: Davidović D; J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 2155/3, 182 00 Prague, Czech Republic.; Faculty of Science, Charles University, Hlavova 8, 128 40 Prague, Czech Republic., Kukulka M; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland., Sarmento MJ; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal., Mikhalyov I; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Gretskaya N; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Chmelová B; J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 2155/3, 182 00 Prague, Czech Republic.; Faculty of Mathematics and Physics, Charles University, Ke Karlovu, 2027/3, 121 16 Prague, Czech Republic., Ricardo JC; J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 2155/3, 182 00 Prague, Czech Republic., Hof M; J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 2155/3, 182 00 Prague, Czech Republic., Cwiklik L; J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 2155/3, 182 00 Prague, Czech Republic., Šachl R; J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 2155/3, 182 00 Prague, Czech Republic.
المصدر: The journal of physical chemistry letters [J Phys Chem Lett] 2023 Jun 29; Vol. 14 (25), pp. 5791-5797. Date of Electronic Publication: 2023 Jun 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101526034 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7185 (Electronic) Linking ISSN: 19487185 NLM ISO Abbreviation: J Phys Chem Lett Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Chemical Society
مواضيع طبية MeSH: Gangliosides*/chemistry , Sphingomyelins*, Glycosphingolipids ; G(M1) Ganglioside ; Molecular Dynamics Simulation
مستخلص: Gangliosides are important glycosphingolipids involved in a multitude of physiological functions. From a physicochemical standpoint, this is related to their ability to self-organize into nanoscopic domains, even at molar concentrations of one per 1000 lipid molecules. Despite recent experimental and theoretical efforts suggesting that a hydrogen bonding network is crucial for nanodomain stability, the specific ganglioside moiety decisive for the development of these nanodomains has not yet been identified. Here, we combine an experimental technique achieving nanometer resolution (Förster resonance energy transfer analyzed by Monte Carlo simulations) with atomistic molecular dynamic simulations to demonstrate that the sialic acid (Sia) residue(s) at the oligosaccharide headgroup dominates the hydrogen bonding network between gangliosides, driving the formation of nanodomains even in the absence of cholesterol or sphingomyelin. Consequently, the clustering pattern of asialoGM 1 , a Sia-depleted glycosphingolipid bearing three glyco moieties, is more similar to that of structurally distant sphingomyelin than that of the closely related gangliosides GM 1 and GD 1a with one and two Sia groups, respectively.
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المشرفين على المادة: 0 (Gangliosides)
0 (Sphingomyelins)
0 (Glycosphingolipids)
37758-47-7 (G(M1) Ganglioside)
تواريخ الأحداث: Date Created: 20230616 Date Completed: 20230630 Latest Revision: 20230705
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10316399
DOI: 10.1021/acs.jpclett.3c00761
PMID: 37327454
قاعدة البيانات: MEDLINE
الوصف
تدمد:1948-7185
DOI:10.1021/acs.jpclett.3c00761