دورية أكاديمية
أعرض في EDS

Early vascular ageing phenotypes and urinary targeted metabolomics in children and young adults: the ExAMIN Youth SA and African-PREDICT studies.

التفاصيل البيبلوغرافية
العنوان: Early vascular ageing phenotypes and urinary targeted metabolomics in children and young adults: the ExAMIN Youth SA and African-PREDICT studies.
المؤلفون: Craig A; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa., Kruger R; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Gafane-Matemane LF; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Louw R; Human Metabolomics, North-West University, Potchefstroom Campus, Potchefstroom, South Africa., Mels CMC; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa. carina.mels@nwu.ac.za.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. carina.mels@nwu.ac.za.
المصدر: Amino acids [Amino Acids] 2023 Aug; Vol. 55 (8), pp. 1049-1062. Date of Electronic Publication: 2023 Jun 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 9200312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1438-2199 (Electronic) Linking ISSN: 09394451 NLM ISO Abbreviation: Amino Acids Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Wien ; New York : Springer-Verlag, c1991-
مواضيع طبية MeSH: Cardiovascular Diseases* , Pulse Wave Analysis*/methods, Child ; Humans ; Young Adult ; Aging ; beta-Alanine ; Blood Pressure ; Histidine ; Metabolomics ; Phenotype ; Risk Factors ; Child, Preschool ; Adult
مستخلص: Some individuals are susceptible to accelerated biological ageing, resulting in premature alterations in arterial structure and function. Identifying early-onset vascular ageing characterised by arterial stiffening is vital for intervention and preventive strategies. We stratified and phenotyped healthy children (5-9 yrs) and young adults (20-30 yrs) into their vascular ageing extremes established by carotid-femoral pulse wave velocity (cfPWV) percentiles (i.e., healthy vascular ageing (HVA) and early vascular ageing (EVA)). We compared anthropometric, cardiovascular, and metabolomic profiles and explored associations between cfPWV and urinary metabolites. Children and adults in the EVA groups displayed higher levels of adiposity, cardiovascular, and lifestyle risk factors (adults only) (all p ≤ 0.018). In adults, several urinary metabolites were lower in the EVA group (all q ≤ 0.039) when compared to the HVA group, with no differences observed in children. In multiple regression analysis (adults only), we found inverse associations between cfPWV with histidine (adj. R 2  = 0.038; β = -0.192; p = 0.013) and beta-alanine (adj. R 2  = 0.034; β = -0.181; p = 0.019) in the EVA group, but with arginine (adj. R 2  = 0.021; β = -0.160; p = 0.024) in the HVA group. The inverse associations of beta-alanine and histidine with cfPWV in the EVA group is suggestive that asymptomatic young adults who present with an altered metabolomic and less desired cardiovascular profile in combination with unfavourable lifestyle behaviours may be predisposed to early-onset vascular ageing. Taken together, screening on both a phenotypic and metabolic level may prove important in the early detection, prevention, and intervention of advanced biological ageing.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Adults; Arterial stiffness; Children; Early vascular ageing; Targeted metabolomics
المشرفين على المادة: 11P2JDE17B (beta-Alanine)
4QD397987E (Histidine)
تواريخ الأحداث: Date Created: 20230616 Date Completed: 20230925 Latest Revision: 20230925
رمز التحديث: 20230925
مُعرف محوري في PubMed: PMC10514129
DOI: 10.1007/s00726-023-03293-2
PMID: 37328631
قاعدة البيانات: MEDLINE
الوصف
تدمد:1438-2199
DOI:10.1007/s00726-023-03293-2