دورية أكاديمية
[Antithrombotiques oraux et pronostic après un an des patients atteints de fibrillation auriculaire dans un milieu à ressources limitées].
| العنوان: | [Antithrombotiques oraux et pronostic après un an des patients atteints de fibrillation auriculaire dans un milieu à ressources limitées]. |
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| عنوان ترانسليتريتد: | Oral antithrombotic therapy and one-year clinical outcomes among patients with atrial fibrillation in resource-limited settings. |
| المؤلفون: | Dzudie A; Department of Internal Medicine and sub-specialities, Douala General Hospital, Douala, Cameroon; Departments of Physiology and Internal Medicine, Faculty of Medicine and biomedical sciences, University of Yaounde I, Yaounde, Cameroon; Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon. Electronic address: aitdzudie@yahoo.com., Kwawa I; Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon., Magha I; Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon., Mouliom S; Department of Internal Medicine and sub-specialities, Douala General Hospital, Douala, Cameroon; Department of Medicine, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon., Magnerou AM; Department of Medicine, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon., Massi DG; Department of Internal Medicine and sub-specialities, Douala General Hospital, Douala, Cameroon; Faculty of Health Sciences, University of Buea, Buea, Cameroon., Barche B; Department of Medicine, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon., Ndjebet J; Douala Cardiovascular Center, Douala, Cameroon., Fotsing MM; Douala Cardiovascular Center, Douala, Cameroon., Lade V; Department of Internal Medicine and sub-specialities, Douala General Hospital, Douala, Cameroon., Djomou A; Clinique Cœur Et Vie, Douala, Cameroon., Ndom MS; Department of Medicine, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon., Abanda MH; Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon., Majunda Ekaney DS; Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon., Ongeh NJ; Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon., Ebasone PV; Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon., Kamdem F; Department of Internal Medicine and sub-specialities, Douala General Hospital, Douala, Cameroon; Department of Medicine, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon., Mbatchou BH; Department of Internal Medicine and sub-specialities, Douala General Hospital, Douala, Cameroon., Njankouo YM; Department of Internal Medicine and sub-specialities, Douala General Hospital, Douala, Cameroon; Department of Medicine, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon. |
| المصدر: | Annales de cardiologie et d'angeiologie [Ann Cardiol Angeiol (Paris)] 2023 Oct; Vol. 72 (4), pp. 101616. Date of Electronic Publication: 2023 Jun 16. |
| نوع المنشور: | Observational Study; English Abstract; Journal Article |
| اللغة: | French |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: France NLM ID: 0142167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3181 (Electronic) Linking ISSN: 00033928 NLM ISO Abbreviation: Ann Cardiol Angeiol (Paris) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Paris : Elsevier Original Publication: Paris, Expansion scientifique française. |
| مواضيع طبية MeSH: | Atrial Fibrillation*/diagnosis , Atrial Fibrillation*/drug therapy , Atrial Fibrillation*/complications , Heart Failure*/diagnosis , Heart Failure*/drug therapy , Heart Failure*/complications , Stroke*/etiology , Stroke*/prevention & control , Stroke*/epidemiology, Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Anticoagulants/therapeutic use ; Cameroon ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Prospective Studies ; Risk Factors ; Young Adult ; Adult |
| مستخلص: | Background: Atrial fibrillation is associated with increased risk of morbidity and mortality. There's limited data on the outcomes of atrial fibrillation patients in Africa. We aimed at evaluating the clinical outcomes and their associated factors in patients with atrial fibrillation on antithrombotic therapy in Douala. Methods: The Douala atrial fibrillation registry is a prospective, observational cohort study of patients with atrial fibrillation followed by cardiovascular specialists in 3 specialized care centres. From January to April 2018, all patients with electrocardiographic diagnosis of atrial fibrillation, aged 21 years or older, were included in the registry provided their consent. The composite endpoint of heart failure, stroke, major bleeding, hospitalisation and mortality as well as their individual occurrence were assessed at 12 months. Results: Of 113 participants that were included, 6(5.3%) were lost to follow-up. The mean age was 70 ± 12 years, with a female predominance (68%). After a mean follow-up time of 12.2 ± 0.7 months, 51 patients (47.7%) had at least one outcome. Hospitalisation, all-cause mortality, heart failure, stroke and major bleeding rates were 33.3%, 16.8%, 15.2%, 4.8% and 2.9% respectively. There was no significant difference in the composite outcome and mortality according to the antithrombotic treatment. Previous heart failure [aHR = 3.07, 95% CI (1.48-6.36) p = 0.003], new onset atrial fibrillation [aHR= 4.00, 95% CI (0.96-8.19) p < 0.001] and paroxystic atrial fibrillation [aHR= 3.74, 95% CI (1.33-10.53) p = 0.013] were significant predictors of outcome. Conclusion: Half of patients with atrial fibrillation in this registry developed an outcome after one year of follow-up, with heart failure, new onset and paroxystic atrial fibrillation being the main predicting factors. Diagnosing and managing atrial fibrillation in patients with heart disease should therefore be considered as a key priority. Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interest. (Copyright © 2023 Elsevier Masson SAS. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antithrombotic treatment; Atrial fibrillation; Fibrillation auriculaire; Heart failure; Stroke, Resource-limited setting; accident vasculaire cérébral; insuffisance cardiaque; milieu à ressources limitées; traitement antithrombotique |
| المشرفين على المادة: | 0 (Anticoagulants) |
| تواريخ الأحداث: | Date Created: 20230618 Date Completed: 20231025 Latest Revision: 20231025 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ancard.2023.101616 |
| PMID: | 37331159 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1768-3181 |
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| DOI: | 10.1016/j.ancard.2023.101616 |