Editorial & Opinion
COVID-19 outcomes in people living with HIV: Peering through the waves.
| العنوان: | COVID-19 outcomes in people living with HIV: Peering through the waves. |
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| المؤلفون: | Sales TLS; Universidade Federal de São João del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, MG, Brazil; Instituto de Avaliação de Tecnologia em Saúde (IATS), Porto Alegre, RS, Brazil. Electronic address: thaislorennass30@yahoo.com.br., Souza-Silva MVR; Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Delfino-Pereira P; Instituto de Avaliação de Tecnologia em Saúde (IATS), Porto Alegre, RS, Brazil; Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Neves JVB; Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brazil., Sacioto MF; Hospital Eduardo de Menezes, Belo Horizonte, MG, Brazil., Assis VCM; Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brazil., Duani H; Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Oliveira NR; Hospital Eduardo de Menezes, Belo Horizonte, MG, Brazil., Sampaio NDCS; Hospital Eduardo de Menezes, Belo Horizonte, MG, Brazil., Ramos LEF; Department of Statistics, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Schwarzbold AV; Hospital Universitário de Santa Maria, Santa Maria, RS, Brazil., Jorge AO; Hospital Risoleta Tolentino Neves, Belo Horizonte, MG, Brazil., Scotton ALBA; Hospital Regional Antônio Dias, Patos de Minas, MG, Brazil., Castro BM; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Silva CTCAD; Hospital Santo Antônio, Curvelo, MG, Brazil., Ramos CM; Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brazil., Anschau F; Hospital Nossa Senhora da Conceição, Porto Alegre, RS, Brazil; Hospital Cristo Redentor, Porto Alegre, RS, Brazil., Botoni FA; Hospital Julia Kubitschek, Belo Horizonte, MG, Brazil., Grizende GMS; Hospital Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, MG, Brazil., Nascimento GF; Hospital UNIMED BH, Belo Horizonte, MG, Brazil., Ruschel KB; Hospital Mãe de Deus, Porto Alegre, RS, Brazil; Hospital Universitário Canoas, Canoas, RS, Brazil., Menezes LSM; Hospital Metropolitano Odilon Behrens, Belo Horizonte, MG, Brazil., Castro LC; Hospital Bruno Born, Lajeado, RS, Brazil., Nasi LA; Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Carneiro M; Hospital Santa Cruz, Santa Cruz do Sul, RS, Brazil., Godoy MF; Hospital São Lucas PUCRS, Porto Alegre, RS, Brazil., Nogueira MCA; Hospitais da Rede Mater Dei, Belo Horizonte, MG, Brazil., Guimarães Júnior MH; Hospital Márcio Cunha, Ipatinga, MG, Brazil., Ziegelmann PK; Hospital Tacchini, Bento Gonçalves, RS, Brazil., Almeida RC; Hospital Nossa Senhora da Conceição, Porto Alegre, RS, Brazil; Hospital Cristo Redentor, Porto Alegre, RS, Brazil., Francisco SC; Hospital Metropolitano Doutor Célio de Castro, Belo Horizonte, MG, Brazil., Silveira Neto ST; Medical School, Universidade Federal de São João Del-Rei, Divinópolis, MG, Brazil., Araújo SF; Hospital Semper, Belo Horizonte, MG, Brazil., Avelino-Silva TJ; Laboratório de Investigação Médica em Envelhecimento (LIM-66), Serviço de Geriatria, Hospital das Clínicas HCFMUSP, Medical School, Universidade de São Paulo, São Paulo, SP, Brazil; Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Aliberti MJR; Laboratório de Investigação Médica em Envelhecimento (LIM-66), Serviço de Geriatria, Hospital das Clínicas HCFMUSP, Medical School, Universidade de São Paulo, São Paulo, SP, Brazil; Research Institute, Hospital Sírio-Libanês, São Paulo, SP, Brazil., Pires MC; Department of Statistics, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Silva ESD; Universidade Federal de São João del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, MG, Brazil., Marcolino MS; Instituto de Avaliação de Tecnologia em Saúde (IATS), Porto Alegre, RS, Brazil; Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Telehealth Center, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. |
| المصدر: | Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2023 May 25; Vol. 78, pp. 100223. Date of Electronic Publication: 2023 May 25 (Print Publication: 2023). |
| نوع المنشور: | Editorial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: eCollection Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [New York] : Elsevier Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]- |
| مواضيع طبية MeSH: | COVID-19* , HIV Infections*/complications , HIV Infections*/epidemiology, Female ; Humans ; Middle Aged ; Male ; SARS-CoV-2 ; Retrospective Studies ; Intensive Care Units |
| مستخلص: | Objective: To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods: This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results: Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions: Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group. Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest. (Copyright © 2023 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: COVID-19; HIV; Intensive care unit; Mechanical ventilation; Mortality |
| تواريخ الأحداث: | Date Created: 20230618 Date Completed: 20230620 Latest Revision: 20230621 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10209448 |
| DOI: | 10.1016/j.clinsp.2023.100223 |
| PMID: | 37331214 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1980-5322 |
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| DOI: | 10.1016/j.clinsp.2023.100223 |