Drugst.One - A plug-and-play solution for online systems medicine and network-based drug repurposing.

التفاصيل البيبلوغرافية
العنوان: Drugst.One - A plug-and-play solution for online systems medicine and network-based drug repurposing.
المؤلفون: Maier A; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Hartung M; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Abovsky M; Division of Orthopaedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Centre, Osteoarthritis Research Program, Krembil Research Institute, UHN, Toronto, Canada.; Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD-407, Toronto, ON, M5T 0S8, Canada., Adamowicz K; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Bader GD; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Computer Science, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Baier S; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Blumenthal DB; Department Artificial Intelligence in Biomedical Engineering (AIBE), Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany., Chen J; Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA., Elkjaer ML; Department of Neurology, Odense University Hospital, Odense, Denmark.; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Garcia-Hernandez C; Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain., Helmy M; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Computer Science, University of Toronto, Toronto, ON, Canada., Hoffmann M; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany.; Institute for Advanced Study (Lichtenbergstrasse 2a, D-85748 Garching, Germany), Technical University of Munich, Germany.; National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD 20892, United States of America., Jurisica I; Division of Orthopaedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Centre, Osteoarthritis Research Program, Krembil Research Institute, UHN, Toronto, Canada.; Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD-407, Toronto, ON, M5T 0S8, Canada.; Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, Canada.; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia., Kotlyar M; Division of Orthopaedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Centre, Osteoarthritis Research Program, Krembil Research Institute, UHN, Toronto, Canada.; Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD-407, Toronto, ON, M5T 0S8, Canada., Lazareva O; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Junior Clinical Cooperation Unit Multiparametric methods for early detection of prostate cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany., Levi H; Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel., List M; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Lobentanzer S; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany., Loscalzo J; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Malod-Dognin N; Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain., Manz Q; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Matschinske J; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Mee M; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Computer Science, University of Toronto, Toronto, ON, Canada., Oubounyt M; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Pico AR; Institute of Data Science and Biotechnology, Gladstone Institutes, 1650 Owens Street, San Francisco, 94158, California, USA., Pillich RT; Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA., Poschenrieder JM; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Pratt D; Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA., Pržulj N; Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain.; Department of Computer Science, University College London, London WC1E 6BT, UK.; ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain., Sadegh S; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Saez-Rodriguez J; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany., Sarkar S; Department Artificial Intelligence in Biomedical Engineering (AIBE), Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany., Shaked G; Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel., Shamir R; Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel., Trummer N; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Turhan U; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Wang R; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zolotareva O; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Baumbach J; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Computational Biomedicine Lab, Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark.
المصدر: ArXiv [ArXiv] 2023 Jul 04. Date of Electronic Publication: 2023 Jul 04.
نوع المنشور: Preprint
اللغة: English
بيانات الدورية: Country of Publication: United States NLM ID: 101759493 Publication Model: Electronic Cited Medium: Internet ISSN: 2331-8422 (Electronic) Linking ISSN: 23318422 NLM ISO Abbreviation: ArXiv Subsets: PubMed not MEDLINE
مستخلص: In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex installation and lack intuitive visual network mining capabilities. To tackle these challenges, we introduce Drugst.One, a platform that assists specialized computational medicine tools in becoming user-friendly, web-based utilities for drug repurposing. With just three lines of code, Drugst.One turns any systems biology software into an interactive web tool for modeling and analyzing complex protein-drug-disease networks. Demonstrating its broad adaptability, Drugst.One has been successfully integrated with 21 computational systems medicine tools. Available at https://drugst.one, Drugst.One has significant potential for streamlining the drug discovery process, allowing researchers to focus on essential aspects of pharmaceutical treatment research.
Competing Interests: JSR reports funding from GSK, Pfizer and Sanofi and fees from Travere Therapeutics and Astex Pharmaceuticals.
التعليقات: Update in: Nucleic Acids Res. 2024 Jul 5;52(W1):W481-W488. doi: 10.1093/nar/gkae388. (PMID: 38783119)
فهرسة مساهمة: Keywords: Biomedical data analysis; Biomedical network exploration; Data visualization; Drug repurposing; Interactive network enrichment; Network integration; Systems medicine
تواريخ الأحداث: Date Created: 20230619 Latest Revision: 20240704
رمز التحديث: 20240705
مُعرف محوري في PubMed: PMC10274948
PMID: 37332567
قاعدة البيانات: MEDLINE