دورية أكاديمية
Firefly luciferin methyl ester illuminates the activity of multiple serine hydrolases.
| العنوان: | Firefly luciferin methyl ester illuminates the activity of multiple serine hydrolases. |
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| المؤلفون: | Mohammad I; Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, 364 Plantation St., Worcester, MA 01605, USA. Stephen.miller@umassmed.edu., Liebmann KL; Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, 364 Plantation St., Worcester, MA 01605, USA. Stephen.miller@umassmed.edu., Miller SC; Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, 364 Plantation St., Worcester, MA 01605, USA. Stephen.miller@umassmed.edu. |
| المصدر: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Jul 06; Vol. 59 (55), pp. 8552-8555. Date of Electronic Publication: 2023 Jul 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Firefly Luciferin* , Monoacylglycerol Lipases*, Amidohydrolases ; Serine ; Enzyme Inhibitors |
| مستخلص: | Firefly luciferin methyl ester is hydrolyzed by monoacylglycerol lipase MAGL, amidase FAAH, poorly-characterized hydrolase ABHD11, and hydrolases known for S -depalmitoylation (LYPLA1/2), not just esterase CES1. This enables activity-based bioluminescent assays for serine hydrolases and suggests that the 'esterase activity' responsible for hydrolyzing ester prodrugs is more diverse than previously supposed. |
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| معلومات مُعتمدة: | R01 DA039961 United States DA NIDA NIH HHS; R01 EB013270 United States EB NIBIB NIH HHS |
| المشرفين على المادة: | 5TBB02N29K (Firefly Luciferin) EC 3.1.1.23 (Monoacylglycerol Lipases) EC 3.5.- (Amidohydrolases) 452VLY9402 (Serine) 0 (Enzyme Inhibitors) |
| تواريخ الأحداث: | Date Created: 20230620 Date Completed: 20230710 Latest Revision: 20240707 |
| رمز التحديث: | 20240707 |
| مُعرف محوري في PubMed: | PMC10347678 |
| DOI: | 10.1039/d3cc02540c |
| PMID: | 37337906 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1364-548X |
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| DOI: | 10.1039/d3cc02540c |