دورية أكاديمية
Integrating, Harmonizing, and Curating Studies With High-Frequency and Hourly Physiological Data: Proof of Concept from Seven Traumatic Brain Injury Data Sets.
| العنوان: | Integrating, Harmonizing, and Curating Studies With High-Frequency and Hourly Physiological Data: Proof of Concept from Seven Traumatic Brain Injury Data Sets. |
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| المؤلفون: | Yaseen A; Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA., Robertson C; Department of Neurosurgery, and University of Washington, Seattle, Washington, USA., Cruz Navarro J; Department of Anesthesiology Baylor College of Medicine, University of Washington, Seattle, Washington, USA., Chen J; Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA., Heckler B; Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA., DeSantis SM; Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA., Temkin N; Department of Department of Neurological Surgery and Biostatistics, University of Washington, Seattle, Washington, USA., Barber J; Department of Neurological Surgery, Harborview Medical Center, University of Washington, Seattle, Washington, USA., Foreman B; Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA., Diaz-Arrastia R; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Chesnut R; Department of Neurological Surgery, Harborview Medical Center, University of Washington, Seattle, Washington, USA., Manley GT; Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, Emory University School of Medicine, Atlanta, Georgia, USA., Wright DW; Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Vassar M; Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, Emory University School of Medicine, Atlanta, Georgia, USA., Ferguson AR; Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, Emory University School of Medicine, Atlanta, Georgia, USA., Markowitz AJ; Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, Emory University School of Medicine, Atlanta, Georgia, USA., Yamal JM; Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA. |
| المصدر: | Journal of neurotrauma [J Neurotrauma] 2023 Nov; Vol. 40 (21-22), pp. 2362-2375. Date of Electronic Publication: 2023 Aug 16. |
| نوع المنشور: | Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8811626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9042 (Electronic) Linking ISSN: 08977151 NLM ISO Abbreviation: J Neurotrauma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: New York, NY : Mary Ann Liebert, c1988- |
| مواضيع طبية MeSH: | Brain Injuries, Traumatic*/drug therapy , Brain Injuries*/drug therapy, Humans ; Prospective Studies ; Cytidine Diphosphate Choline/therapeutic use ; Information Dissemination |
| مستخلص: | Research in severe traumatic brain injury (TBI) has historically been limited by studies with relatively small sample sizes that result in low power to detect small, yet clinically meaningful outcomes. Data sharing and integration from existing sources hold promise to yield larger more robust sample sizes that improve the potential signal and generalizability of important research questions. However, curation and harmonization of data of different types and of disparate provenance is challenging. We report our approach and experience integrating multiple TBI data sets containing collected physiological data, including both expected and unexpected challenges encountered in the integration process. Our harmonized data set included data on 1536 patients from the Citicoline Brain Injury Treatment Trial (COBRIT), Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial (EPO Severe TBI), BEST-TRIP, Progesterone for the Treatment of Traumatic Brain Injury III Clinical Trial (ProTECT III), Transforming Research and Clinical Knowledge in Traumatic brain Injury (TRACK-TBI), Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II (BOOST-2), and Ben Taub General Hospital (BTGH) Research Database studies. We conclude with process recommendations for data acquisition for future prospective studies to aid integration of these data with existing studies. These recommendations include using common data elements whenever possible, a standardized recording system for labeling and timing of high-frequency physiological data, and secondary use of studies in systems such as Federal Interagency Traumatic Brain Injury Research Informatics System (FITBIR), to engage investigators who collected the original data. |
| فهرسة مساهمة: | Keywords: FITBIR; data curation; data harmonization; data integration; physiological data; traumatic brain injury |
| المشرفين على المادة: | 536BQ2JVC7 (Cytidine Diphosphate Choline) |
| تواريخ الأحداث: | Date Created: 20230621 Date Completed: 20231113 Latest Revision: 20231122 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1089/neu.2023.0023 |
| PMID: | 37341031 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-9042 |
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| DOI: | 10.1089/neu.2023.0023 |