دورية أكاديمية
أعرض في EDS

Sex-specific associations between plasma interleukin-6 and depression in persons with and without HIV.

التفاصيل البيبلوغرافية
العنوان: Sex-specific associations between plasma interleukin-6 and depression in persons with and without HIV.
المؤلفون: Petersen KJ; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Yu X; Department of Biostatistics & Data Science, The University of Texas Medical Branch, Galveston, TX, USA., Masters MC; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Lobo JD; Department of Psychiatry, The University of California San Diego, San Diego, CA, USA., Lu T; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Letendre S; Department of Psychiatry, The University of California San Diego, San Diego, CA, USA.; Department of Medicine, The University of California San Diego, San Diego, CA, USA., Ellis RJ; Department of Psychiatry, The University of California San Diego, San Diego, CA, USA., McCutchan JA; Department of Medicine, The University of California San Diego, San Diego, CA, USA., Sundermann E; Department of Psychiatry, The University of California San Diego, San Diego, CA, USA.
المصدر: Brain, behavior, & immunity - health [Brain Behav Immun Health] 2023 Jun 01; Vol. 30, pp. 100644. Date of Electronic Publication: 2023 Jun 01 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101759062 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3546 (Electronic) Linking ISSN: 26663546 NLM ISO Abbreviation: Brain Behav Immun Health Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier Inc., [2020]-
مستخلص: Background: Persons with HIV (PWH) have both more frequent depression and higher levels of plasma inflammatory biomarkers compared to persons without HIV (PWoH). Inflammation and depressive symptoms are linked, including in PWH; however, it is unclear whether these associations differ by HIV serostatus and biological sex.
Methods: Six plasma inflammatory biomarkers were assessed using samples from PWH and PWoH who participated in six NIH-funded studies through the UCSD HIV Neurobehavioral Research Program (HNRP) from 2011 to 2019. Factor analysis was performed to identify intercorrelated groups of biomarkers. Factors and their components were then examined for relationships with Beck Depression Inventory-II (BDI-II) and modifying effects of sex or HIV serostatus using multivariable linear regression, adjusting for demographics, substance use diagnoses, and relevant co-morbidities.
Results: Participants included 150 PWH (age = 48.3 ± 13.1 yr; 88% biologically male) and 138 PWoH (age = 46.3 ± 15.9; 56% male). Two inflammatory factors were identified: Factor 1 loaded on interleukin-6 (IL-6), C-reactive protein (CRP), and D-dimer; Factor 2 loaded on interleukin-8, chemokine C-C ligand 2 (CCL2), and chemokine C-X-C ligand 10 (CXCL10). Sex modified the effect of Factor 1 on BDI-II, with a more positive association for men than women ( p  = 0.04). No significant association between Factor 2 and BDI-II was found. Of the biomarkers in Factor 1, only IL-6 was significantly associated with BDI-II and was modified by sex ( p  = 0.003). In sex-stratified analysis, a positive association was found for men (β = 5.42; 95% confidence interval = [1.32, 9.52]) but not women (β = -3.88; 95% C.I. = [-11.02, 3.26]). No HIV-related interactions were detected.
Interpretation: We identified a depression-associated inflammatory factor present in both PWH and PWoH, consistent with prior studies of PWH only. The association was driven by a correlation between IL-6 and depression exclusively in men, suggesting that the depression-inflammation link differs by sex. Future studies of depression etiology or treatment, including those on persons with HIV, should consider the impact of biological sex in both design and analysis.
Competing Interests: None.
(© 2023 The Authors. Published by Elsevier Inc.)
References: Transl Psychiatry. 2021 Mar 15;11(1):167. (PMID: 33723220)
Br J Psychiatry. 1991 Nov;159:645-53, 658. (PMID: 1756340)
J Clin Cell Immunol. 2014 Dec;5(6):. (PMID: 25674354)
Psychosom Med. 2009 Feb;71(2):171-86. (PMID: 19188531)
Neuropathol Appl Neurobiol. 2001 Aug;27(4):326-35. (PMID: 11532163)
Brain Behav Immun. 2019 Jan;75:200-207. (PMID: 30394311)
Nat Rev Immunol. 2016 Jan;16(1):22-34. (PMID: 26711676)
J Psychiatr Res. 2021 Aug;140:350-356. (PMID: 34139457)
Ann Ist Super Sanita. 2016 Apr-Jun;52(2):198-204. (PMID: 27364394)
Neuropsychopharmacology. 2019 Feb;44(3):635-641. (PMID: 30391995)
Biol Psychiatry. 2003 Aug 1;54(3):307-16. (PMID: 12893106)
J Neurovirol. 2019 Dec;25(6):735-740. (PMID: 31165368)
Cell. 2018 Nov 29;175(6):1701-1715.e16. (PMID: 30449622)
JAMA Psychiatry. 2013 Jan;70(1):31-41. (PMID: 22945416)
Psychol Med. 2009 Mar;39(3):413-23. (PMID: 18533059)
Expert Opin Investig Drugs. 2015 Apr;24(4):459-75. (PMID: 25585966)
Brain Behav Immun. 2012 May;26(4):568-72. (PMID: 22306454)
J Acquir Immune Defic Syndr. 2015 May 1;69(1):18-28. (PMID: 25942456)
BMC Immunol. 2018 Jan 03;19(1):1. (PMID: 29298663)
J Infect Dis. 2014 Oct 15;210(8):1248-59. (PMID: 24795473)
Psychosom Med. 2017 Sep;79(7):749-756. (PMID: 28498278)
J Acquir Immune Defic Syndr. 2021 Apr 15;86(5):600-606. (PMID: 33298794)
JAMA Psychiatry. 2013 Feb;70(2):176-84. (PMID: 23266538)
Int J Methods Psychiatr Res. 2002;11(2):75-82. (PMID: 12459797)
Mol Psychiatry. 2008 Aug;13(8):800-12. (PMID: 18504423)
J Affect Disord. 2013 Sep 25;150(3):736-44. (PMID: 23870425)
BMC Public Health. 2021 Jun 10;21(1):1113. (PMID: 34112126)
Brain Behav Immun. 2016 Aug;56:105-13. (PMID: 26883521)
Brain Behav Immun Health. 2020 Aug 13;7:100121. (PMID: 34589877)
Transl Psychiatry. 2012 Feb 21;2:e79. (PMID: 22832816)
HIV Med. 2022 May;23(5):465-473. (PMID: 34704355)
J Acquir Immune Defic Syndr. 2011 Oct 1;58(2):181-7. (PMID: 21857529)
AIDS Behav. 2019 Dec;23(12):3452-3459. (PMID: 31367965)
Br J Nutr. 2008 May;99(5):931-40. (PMID: 17977473)
AIDS Patient Care STDS. 2004 Oct;18(10):594-603. (PMID: 15630787)
Psychosom Med. 2020 Jun;82(5):461-470. (PMID: 32282648)
Brain Behav Immun. 2020 Jul;87:901-909. (PMID: 32113908)
Am J Epidemiol. 2019 Nov 1;188(11):1994-2003. (PMID: 31642472)
Neurology. 2010 Dec 7;75(23):2087-96. (PMID: 21135382)
Annu Rev Med. 2011;62:141-55. (PMID: 21090961)
J Int Neuropsychol Soc. 1995 May;1(3):231-51. (PMID: 9375218)
Neurology. 2006 Apr 25;66(8):1255-7. (PMID: 16636247)
J Neurol Neurosurg Psychiatry. 2020 Jan;91(1):21-32. (PMID: 31658959)
Biol Psychiatry. 2009 Sep 1;66(5):407-14. (PMID: 19423079)
J Affect Disord. 2014 Dec;169:15-20. (PMID: 25128861)
AIDS Patient Care STDS. 2003 Mar;17(3):115-20. (PMID: 12724007)
Cell Immunol. 2015 Apr;294(2):102-10. (PMID: 25700766)
AIDS Behav. 2017 Nov;21(11):3238-3246. (PMID: 28484888)
Prog Neurobiol. 2019 May;176:86-102. (PMID: 30721749)
Brain Behav Immun. 2014 Nov;42:89-95. (PMID: 24929193)
Curr Neuropharmacol. 2016;14(7):705-20. (PMID: 26893168)
Neuropsychopharmacology. 2019 Apr;44(5):923-929. (PMID: 30643228)
Psychoneuroendocrinology. 2018 Sep;95:43-49. (PMID: 29800779)
J Neurovirol. 2018 Oct;24(5):616-628. (PMID: 30022427)
Brain Behav Immun. 2021 Jul;95:106-114. (PMID: 33631287)
Pharmacol Rep. 2021 Aug;73(4):1052-1062. (PMID: 34031863)
Mol Psychiatry. 2018 Feb;23(2):335-343. (PMID: 27752078)
Biol Psychiatry. 2015 Feb 1;77(3):e19-e20. (PMID: 25104172)
Curr Psychiatry Rep. 2015 Jan;17(1):530. (PMID: 25413636)
Arch Gen Psychiatry. 2001 Aug;58(8):721-8. (PMID: 11483137)
معلومات مُعتمدة: P30 MH062512 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: Depression; HIV infection; Inflammation; Sex differences
تواريخ الأحداث: Date Created: 20230622 Latest Revision: 20231201
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10279778
DOI: 10.1016/j.bbih.2023.100644
PMID: 37347049
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-3546
DOI:10.1016/j.bbih.2023.100644