دورية أكاديمية
أعرض في EDS

Changes in Oesophageal Transit, Macro-Reflux Events, and Gastric Emptying Correlate with Improvements in Gastro-Intestinal Symptoms and Food Tolerance Early Post Sleeve Gastrectomy.

التفاصيل البيبلوغرافية
العنوان: Changes in Oesophageal Transit, Macro-Reflux Events, and Gastric Emptying Correlate with Improvements in Gastro-Intestinal Symptoms and Food Tolerance Early Post Sleeve Gastrectomy.
المؤلفون: Wickremasinghe AC; Monash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia. anagi.wickremasinghe@monash.edu., Johari Y; Monash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.; Oesophago-gastric and Bariatric Unit, Department of General Surgery, The Alfred Hospital, Melbourne, Australia., Yue H; Department of Nuclear Medicine, The Alfred Hospital, Melbourne, Australia., Laurie C; Monash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia., Shaw K; Monash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.; Oesophago-gastric and Bariatric Unit, Department of General Surgery, The Alfred Hospital, Melbourne, Australia., Playfair J; Monash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia., Beech P; Department of Nuclear Medicine, The Alfred Hospital, Melbourne, Australia., Hebbard G; Department of Gastroenterology, Royal Melbourne Hospital and University of Melbourne, Parkville, VIC, 3050, Australia., Yap KS; Department of Nuclear Medicine, The Alfred Hospital, Melbourne, Australia.; Department of Medicine, Monash University, Alfred Hospital Campus, Melbourne, VIC, 3004, Australia., Brown W; Monash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.; Oesophago-gastric and Bariatric Unit, Department of General Surgery, The Alfred Hospital, Melbourne, Australia., Burton P; Monash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.; Oesophago-gastric and Bariatric Unit, Department of General Surgery, The Alfred Hospital, Melbourne, Australia.
المصدر: Obesity surgery [Obes Surg] 2023 Aug; Vol. 33 (8), pp. 2384-2395. Date of Electronic Publication: 2023 Jun 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9106714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1708-0428 (Electronic) Linking ISSN: 09608923 NLM ISO Abbreviation: Obes Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : New York : Springer Science + Business Media
Original Publication: Oxford, OX, UK : Rapid Communications of Oxford, [1991-
مواضيع طبية MeSH: Obesity, Morbid*/surgery , Gastroesophageal Reflux*/etiology, Female ; Humans ; Adult ; Middle Aged ; Male ; Gastric Emptying/physiology ; Gastrectomy/methods
مستخلص: Purpose: There are significant alterations in gastro-intestinal function, food tolerance, and symptoms following sleeve gastrectomy (SG). These substantially change over the first year, but it is unclear what the underlying physiological basis for these changes is. We examined changes in oesophageal transit and gastric emptying and how these correlate with changes in gastro-intestinal symptoms and food tolerance.
Material and Methods: Post-SG patients undertook protocolised nuclear scintigraphy imaging along with a clinical questionnaire at 6 weeks, 6 months, and 12 months.
Results: Thirteen patients were studied: mean age (44.8 ± 8.5 years), 76.9% females, pre-operative BMI (46.9 ± 6.7 kg/m2). Post-operative %TWL was 11.9 ± 5.1% (6 weeks) and 32.2 ± 10.1% (12 months), p-value < 0.0001. There was a substantial increase of meal within the proximal stomach; 22.3% (IQR 12%) (6 weeks) vs. 34.2% (IQR 19.7%) (12 months), p = 0.038. Hyper-accelerated transit into the small bowel decreased from 6 weeks 49.6% (IQR 10.8%) to 42.7% (IQR 20.5%) 12 months, p = 0.022. Gastric emptying half-time increased from 6 weeks 19 (IQR 8.5) to 12 months 27 (IQR 11.5) min, p = 0.027. The incidence of deglutitive reflux of semi-solids decreased over time; 46.2% (6 weeks) vs. 18.2% (12 months), p-value < 0.0001. Reflux score of 10.6 ± 7.6 at 6 weeks vs. 3.5 ± 4.4 at 12 months, (p = 0.049) and regurgitation score of 9.9 ± 3.3 at 6 weeks vs. 6.5 ± 1.7, p = 0.021 significantly reduced.
Conclusions: These data demonstrate that there is an increase in the capacity of the proximal gastric sleeve to accommodate substrate over the first year. Gastric emptying remains rapid but reduce over time, correlating with improved food tolerance and reduced reflux symptoms. This is likely the physiological basis for the changes in symptoms and food tolerance observed early post-SG.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Bariatric outcome; Bariatric surgery mechanism; Clinical trial; Food tolerance; Gastric emptying; Gastrointestinal symptoms; Nuclear scintigraphy; Physiology; Reflux; Sleeve
تواريخ الأحداث: Date Created: 20230622 Date Completed: 20230717 Latest Revision: 20231119
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10345052
DOI: 10.1007/s11695-023-06695-z
PMID: 37349670
قاعدة البيانات: MEDLINE
الوصف
تدمد:1708-0428
DOI:10.1007/s11695-023-06695-z