دورية أكاديمية
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Recent Evolution of a Maternally Acting Sex-Determining Supergene in a Fly with Single-Sex Broods.

التفاصيل البيبلوغرافية
العنوان: Recent Evolution of a Maternally Acting Sex-Determining Supergene in a Fly with Single-Sex Broods.
المؤلفون: Baird RB; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom., Urban JM; Department of Embryology, Carnegie Institution for Science, Howard Hughes Medical Institute Research Laboratories, Baltimore, MD, USA., Mongue AJ; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom., Jaron KS; Tree of Life Programme, Wellcome Sanger Institute, Cambridge, United Kingdom., Hodson CN; Department of Zoology, University of British Columbia, Vancouver, Canada., Grewoldt M; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Martin SH; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom., Ross L; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom.
المصدر: Molecular biology and evolution [Mol Biol Evol] 2023 Jul 05; Vol. 40 (7).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 8501455 Publication Model: Print Cited Medium: Internet ISSN: 1537-1719 (Electronic) Linking ISSN: 07374038 NLM ISO Abbreviation: Mol Biol Evol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : New York, NY : Oxford University Press
Original Publication: [Chicago, Ill.] : University of Chicago Press, [c1983-
مواضيع طبية MeSH: Diptera*/genetics, Animals ; Female ; Chromosome Inversion ; Evolution, Molecular ; Genome ; Repetitive Sequences, Nucleic Acid ; Sex Chromosomes/genetics ; X Chromosome/genetics ; Male
مستخلص: Sex determination is a key developmental process, yet it is remarkably variable across the tree of life. The dipteran family Sciaridae exhibits one of the most unusual sex determination systems in which mothers control offspring sex through selective elimination of paternal X chromosomes. Whereas in some members of the family females produce mixed-sex broods, others such as the dark-winged fungus gnat Bradysia coprophila are monogenic, with females producing single-sex broods. Female-producing females were previously found to be heterozygous for a large X-linked paracentric inversion (X'), which is maternally inherited and absent from male-producing females. Here, we assembled and characterized the X' sequence. As close sequence homology between the X and X' made identification of the inversion challenging, we developed a k-mer-based approach to bin genomic reads before assembly. We confirmed that the inversion spans most of the X' chromosome (∼55 Mb) and encodes ∼3,500 genes. Analysis of the divergence between the inversion and the homologous region of the X revealed that it originated very recently (<0.5 Ma). Surprisingly, we found that the X' is more complex than previously thought and is likely to have undergone multiple rearrangements that have produced regions of varying ages, resembling a supergene composed of evolutionary strata. We found functional degradation of ∼7.3% of genes within the region of recombination suppression, but no evidence of accumulation of repetitive elements. Our findings provide an indication that sex-linked inversions are driving turnover of the strange sex determination system in this family of flies.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.)
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معلومات مُعتمدة: United States HHMI Howard Hughes Medical Institute
فهرسة مساهمة: Keywords: evolutionary strata; monogenic reproduction; sex determination; supergene
تواريخ الأحداث: Date Created: 20230623 Date Completed: 20230707 Latest Revision: 20230718
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10321493
DOI: 10.1093/molbev/msad148
PMID: 37352554
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-1719
DOI:10.1093/molbev/msad148