دورية أكاديمية
Immunopathogenic mechanisms and modulatory approaches to graft-versus-host disease prevention in acute myeloid leukaemia.
العنوان: | Immunopathogenic mechanisms and modulatory approaches to graft-versus-host disease prevention in acute myeloid leukaemia. |
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المؤلفون: | Pang Y; Department of Haematologic Oncology and Blood Disorders, Levine Cancer Institute, Charlotte, NC, USA. Electronic address: yifan.pang@atriumhealth.org., Holtzman NG; Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
المصدر: | Best practice & research. Clinical haematology [Best Pract Res Clin Haematol] 2023 Jun; Vol. 36 (2), pp. 101475. Date of Electronic Publication: 2023 May 11. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101120659 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1924 (Electronic) Linking ISSN: 15216926 NLM ISO Abbreviation: Best Pract Res Clin Haematol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: London, U.K. : Baillière Tindall, c2001- |
مواضيع طبية MeSH: | Graft vs Host Disease*/prevention & control , Graft vs Host Disease*/etiology , Hematopoietic Stem Cell Transplantation*/adverse effects , Leukemia, Myeloid, Acute*/therapy, Humans ; Graft vs Leukemia Effect ; Neoplasm Recurrence, Local/complications ; Transplantation, Homologous/adverse effects |
مستخلص: | Allogeneic haematopoietic stem cell transplantation (HSCT) remains the only potential cure for intermediate to high-risk acute myeloid leukaemia (AML). The therapeutic effect of HSCT is largely dependent on the powerful donor-derived immune response against recipient leukaemia cells, known as graft-versus-leukaemia effect (GvL). However, the donor-derived immune system can also cause acute or chronic damage to normal recipient organs and tissues, in a process known as graft-versus-host disease (GvHD). GvHD is a leading cause of non-relapse mortality in HSCT recipients. There are many similarities and cross talk between the immune pathways of GvL and GvHD. Studies have demonstrated that both processes require the presence of mismatched alloantigens between the donor and recipient, and activation of immune responses centered around donor T-cells, which can be further modulated by various recipient or donor factors. Dissecting GvL from GvHD to achieve more effective GvHD prevention and enhanced GvL has been the holy grail of HSCT research. In this review, we focused on the key factors that contribute to the immune responses of GvL and GvHD, the effect on GvL with different GvHD prophylactic strategies, and the potential impact of various AML relapse prevention therapy or treatments on GvHD. Competing Interests: Declaration of competing interest The authors declare no conflicts of interest. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
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معلومات مُعتمدة: | Z99 HL999999 United States ImNIH Intramural NIH HHS |
فهرسة مساهمة: | Keywords: Acute myeloid leukaemia; Allogeneic haematolpoietic stem cell transplantation; Graft-versus-host disease; Graft-versus-leukaemia |
تواريخ الأحداث: | Date Created: 20230623 Date Completed: 20231114 Latest Revision: 20240603 |
رمز التحديث: | 20240603 |
مُعرف محوري في PubMed: | PMC10291443 |
DOI: | 10.1016/j.beha.2023.101475 |
PMID: | 37353287 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1532-1924 |
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DOI: | 10.1016/j.beha.2023.101475 |