دورية أكاديمية
أعرض في EDS

Resistin serum levels and its association with clinical profile and carotid intima-media thickness in psoriasis: a cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Resistin serum levels and its association with clinical profile and carotid intima-media thickness in psoriasis: a cross-sectional study.
المؤلفون: Schlenker SM; Medicine Course, Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brazil., Munhoz SI; Medicine Course, Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brazil., Busanello AR; Medicine Course, Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brazil., Sanches MG; Medicine Course, Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brazil., Kahlow BS; Medicine Course, Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brazil; Rheumatology Service, Hospital Universitário Evangélico Mackenzie, Curitiba, PR, Brazil., Nisihara R; Medicine Course, Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brazil. Electronic address: renatonisihara@gmail.com., Skare TL; Medicine Course, Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brazil; Rheumatology Service, Hospital Universitário Evangélico Mackenzie, Curitiba, PR, Brazil.
المصدر: Anais brasileiros de dermatologia [An Bras Dermatol] 2023 Nov-Dec; Vol. 98 (6), pp. 799-805. Date of Electronic Publication: 2023 Jun 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier España, S.L Country of Publication: Spain NLM ID: 0067662 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1806-4841 (Electronic) Linking ISSN: 03650596 NLM ISO Abbreviation: An Bras Dermatol Subsets: MEDLINE
أسماء مطبوعة: Publication: Barcelona, Spain : Elsevier España, S.L.
Original Publication: Rio De Janeiro : Sociedade Brasileira de Dermatologia
مواضيع طبية MeSH: Arthritis, Psoriatic*/diagnostic imaging , Arthritis, Psoriatic*/complications , Psoriasis*/complications , Atherosclerosis*/diagnostic imaging , Atherosclerosis*/complications, Humans ; Carotid Intima-Media Thickness ; Resistin ; Cross-Sectional Studies ; Risk Factors
مستخلص: Background: Psoriasis is a protean disease associated with several comorbidities that may have increased levels of adiponectin such as resistin. This may affect the patients atherosclerotic risk.
Objective: To study resistin levels in a sample of Brazilian patients with psoriasis and its association with clinical profile, comorbidities, and carotid Intima-Media Thickness (cIMT).
Methods: This is a cross-sectional study of 119 individuals: 34 healthy controls and 85 patients with psoriasis, 42 of which with skin involvement only and 43 with psoriatic arthritis. Clinical and epidemiological data, measurement of PASI (Psoriasis Area Severity Index) and DAPSA (Disease Activity in Psoriatic Arthritis), lipid profile, cIMT by ultrasound were collected from medical records. Resistin serum levels were measured by ELISA.
Results: Patients with psoriasis had higher resistin levels (p=0.009) and worse cIMT (p=0.0002) than controls. In the psoriasis sample, no associations of resistin levels with epidemiological, clinical findings, and activity indexes were found. Resistin serum levels were associated with the presence of diabetes (p=0.008) and metabolic syndrome (p=0.01) and correlated with total cholesterol (r=0.26) and triglycerides (r=0.33) but not with cIMT.
Study Limitations: This work is limited by its transversal design and by the limited number of patients included.
Conclusion: Resistin serum levels are elevated in psoriasis patients. In this sample, clinical, epidemiological, and activity indexes were not linked to resistin serum levels, but atherosclerotic risk factors were.
(Copyright © 2023. Published by Elsevier España, S.L.U.)
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فهرسة مساهمة: Keywords: Arthritis; Atherosclerosis; Psoriasis; Psoriatic; Resistin
المشرفين على المادة: 0 (Resistin)
تواريخ الأحداث: Date Created: 20230624 Date Completed: 20231102 Latest Revision: 20231102
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10589471
DOI: 10.1016/j.abd.2022.10.011
PMID: 37355349
قاعدة البيانات: MEDLINE
الوصف
تدمد:1806-4841
DOI:10.1016/j.abd.2022.10.011