دورية أكاديمية
أعرض في EDS

Stapled β-Hairpin Antimicrobial Peptides with Improved Stability and Activity against Drug-Resistant Gram-Negative Bacteria.

التفاصيل البيبلوغرافية
العنوان: Stapled β-Hairpin Antimicrobial Peptides with Improved Stability and Activity against Drug-Resistant Gram-Negative Bacteria.
المؤلفون: Selvarajan V; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore., Tram NDT; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore., Xu J; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore., Ngen STY; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore., Koh JJ; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore., Teo JWP; Department of Laboratory Medicine, Microbiology Unit, National University Hospital, Singapore 119074, Singapore., Yuen TY; Agency for Science, Technology and Research (A*STAR), Singapore 138665, Singapore., Ee PLR; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.
المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Jul 13; Vol. 66 (13), pp. 8498-8509. Date of Electronic Publication: 2023 Jun 25.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
أسماء مطبوعة: Publication: Washington Dc : American Chemical Society
Original Publication: [Easton, Pa.] : American Chemical Society, [c1963-
مواضيع طبية MeSH: Antimicrobial Cationic Peptides*/chemistry , Antimicrobial Peptides*, Gram-Negative Bacteria ; Bacteria ; Microbial Sensitivity Tests ; Hydrocarbons/chemistry ; Anti-Bacterial Agents/chemistry
مستخلص: Different stapling techniques have been used recently to address the subpar performance of antimicrobial peptides (AMPs) in clinical trials with ample focus on α-helical AMPs. In comparison, a systematic evaluation of such strategies on β-hairpin AMPs is lacking. Herein, we report the design, synthesis, and evaluation of a library of all-hydrocarbon-stapled β-hairpin AMPs with variation in key parameters intended as potent therapeutics against drug-resistant pathogens. We observed an interesting interplay between the activity, stability, and structural strength. Single-stapled peptides with a 6-carbon staple at peptide termini such as 5(c 6 ) displayed the most potent activity against colistin-resistant clinical isolates. Using imaging techniques, we observed translocation of 5(c 6 ) across bacterial membranes without causing extensive damage. Overall, we have engineered novel all-hydrocarbon-stapled β-hairpin AMPs with structural and functional proficiency that can effectively combat resistant pathogens, with findings from this study a point of reference for future interests in developing novel β-hairpin AMPs.
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المشرفين على المادة: 0 (Antimicrobial Cationic Peptides)
0 (Antimicrobial Peptides)
0 (Hydrocarbons)
0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20230626 Date Completed: 20230714 Latest Revision: 20230719
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10350921
DOI: 10.1021/acs.jmedchem.3c00140
PMID: 37357499
قاعدة البيانات: MEDLINE
الوصف
تدمد:1520-4804
DOI:10.1021/acs.jmedchem.3c00140