دورية أكاديمية
Seasonal expressions of COX-1, COX-2, and EP4 in the scent glands of muskrats ( Ondatra zibethicus ).
| العنوان: | Seasonal expressions of COX-1, COX-2, and EP4 in the scent glands of muskrats ( Ondatra zibethicus ). |
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| المؤلفون: | Xie W; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China., Zhang C; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China., Gao Q; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China., Liu Y; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China., Zhang H; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China., Weng Q; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China. |
| المصدر: | American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2023 Sep 01; Vol. 325 (3), pp. R238-R247. Date of Electronic Publication: 2023 Jun 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society |
| مواضيع طبية MeSH: | Dinoprostone*/metabolism , Arvicolinae*/genetics , Arvicolinae*/metabolism, Animals ; Cyclooxygenase 2/genetics ; Seasons ; Scent Glands/metabolism ; RNA, Messenger/metabolism ; Receptors, Prostaglandin E, EP4 Subtype/genetics ; Receptors, Prostaglandin E, EP4 Subtype/metabolism |
| مستخلص: | Prostaglandins (PGs) serve as signaling molecules that regulate various physiological processes, including inflammation, immune response, blood clotting, and reproduction. The aim of this study was to investigate the immunolocalizations and expression patterns of prostaglandin-E2 (PGE2), cyclooxygenase (COX)-1, and COX-2, as well as its receptor subtypes 4 (EP4) in the scent glands of muskrats ( Ondatra zibethicus ) during the breeding and nonbreeding periods. There were significant seasonal differences in the scent glandular mass, with higher values in the breeding season and relatively low in the nonbreeding season. PGE2, EP4, COX-1, and COX-2 have been immunolocalized in the scent glandular and epithelial cells in both breeding and nonbreeding seasons, whereas no immunostaining was observed in the interstitial cells. The protein and mRNA expression levels of EP4, COX-1, and COX-2 were higher in the scent glands of the breeding season than those of the nonbreeding season. The mean mRNA levels of EP4, COX-1, and COX-2 were positively correlated with the scent glandular weights. The circulating follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), and PGE2, as well as scent glandular PGE2 and dihydrotestosterone (DHT) concentrations, were also significantly higher in the breeding season. In addition, the transcriptomic study in the scent glands identified that differentially expressed genes might be related to fatty carboxylic monocarboxylic acid, steroidogenic-related pathways, and prostanoid metabolic processes. These findings suggested that prostaglandin-E2 might play an essential autocrine or paracrine role in regulating seasonal changes in the scent glandular functions of the muskrats. |
| فهرسة مساهمة: | Keywords: COX; EP4; PGE2; muskrats; scent glands |
| المشرفين على المادة: | EC 1.14.99.1 (Cyclooxygenase 2) K7Q1JQR04M (Dinoprostone) 0 (RNA, Messenger) 0 (Receptors, Prostaglandin E, EP4 Subtype) |
| تواريخ الأحداث: | Date Created: 20230626 Date Completed: 20230803 Latest Revision: 20230823 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1152/ajpregu.00113.2023 |
| PMID: | 37358350 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1490 |
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| DOI: | 10.1152/ajpregu.00113.2023 |