دورية أكاديمية
أعرض في EDS

Effects of aerobic exercise on cardiac function and gene expression of NADPH oxidases in diaphragm muscle of rats with aortic stenosis-induced heart failure.

التفاصيل البيبلوغرافية
العنوان: Effects of aerobic exercise on cardiac function and gene expression of NADPH oxidases in diaphragm muscle of rats with aortic stenosis-induced heart failure.
المؤلفون: Janini Gomes M; Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX, United States., Sabela AK; Physiotherapy Department, UNOESTE, Presidente Prudente, Brazil.; Post-graduate Program, Animal Science, UNOESTE, Presidente Prudente, Brazil., Ferreira ITP; Physiotherapy Department, UNOESTE, Presidente Prudente, Brazil., de Souza SLB; Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., Mota GAF; Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., da Silva VL; Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., de Campos DHS; Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., Lima ARR; Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., Carvalho MR; Federal University of Mato Grosso Do Sul (UFMS), Campo Grande, Brazil., Bazan SGZ; Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., Corrêa CR; Pathology Department, Sao Paulo State University (UNESP), Botucatu, Brazil., Cicogna AC; Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., Okoshi MP; Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil., Pacagnelli FL; Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX, United States.; Physiotherapy Department, UNOESTE, Presidente Prudente, Brazil.
المصدر: Frontiers in physiology [Front Physiol] 2023 Jun 08; Vol. 14, pp. 1182303. Date of Electronic Publication: 2023 Jun 08 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: We evaluated the influence of aerobic physical exercise (EX) on gene-encoding proteins associated with oxidative stress in diaphragm muscle of rats with aortic stenosis-induced heart failure (HF). Wistar male rats were divided into four groups: Control sedentary (C); Control exercise (C-Ex); Sedentary aortic stenosis (AS); Aortic stenosis exercise (AS-Ex). Exercised rats trained 5 times a week for 10 weeks on a treadmill. Statistical analysis was performed by ANOVA or Kruskal-Wallis test. In the final echocardiogram, animals with aortic stenosis subjected to exercise demonstrated improvement in systolic function compared to the sedentary aortic stenosis group. In diaphragm muscle, the activity of antioxidant enzymes, malondialdehyde malondialdehyde concentration, protein carbonylation, and protein expression of p65 and its inhibitor IκB did not differ between groups. Alterations in gene expression of sources that generate reactive species of oxygen were observed in AS-Ex group, which showed decreased mRNA abundance of NOX2 and NOX4 compared to the aortic stenosis group ( p < 0.05). We concluded that aerobic exercise has a positive impact during heart failure, ameliorating systolic dysfunction and biomarkers of oxidative stress in diaphragm muscle of rats with aortic stenosis-induced heart failure.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Janini Gomes, Sabela, Ferreira, de Souza, Mota, da Silva, de Campos, Lima, Carvalho, Bazan, Corrêa, Cicogna, Okoshi and Pacagnelli.)
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فهرسة مساهمة: Keywords: aerobic physical exercise; aortic stenosis; diaphragm; heart failure; oxidative stress
تواريخ الأحداث: Date Created: 20230626 Latest Revision: 20230701
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10285051
DOI: 10.3389/fphys.2023.1182303
PMID: 37362442
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2023.1182303