دورية أكاديمية
The microbiota of pregnant women with SARS-CoV-2 and their infants.
العنوان: | The microbiota of pregnant women with SARS-CoV-2 and their infants. |
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المؤلفون: | Leftwich HK; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Massachusetts Memorial Health, University of Massachusetts Chan Medical School, Worcester, MA, USA., Vargas-Robles D; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Rojas-Correa M; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Yap YR; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Bhattarai S; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Ward DV; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Fujimori G; Department of Medicine. Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Forconi CS; Department of Medicine. Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Yeboah T; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Massachusetts Memorial Health, University of Massachusetts Chan Medical School, Worcester, MA, USA., Carter A; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Massachusetts Memorial Health, University of Massachusetts Chan Medical School, Worcester, MA, USA., Kastrinakis A; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Massachusetts Memorial Health, University of Massachusetts Chan Medical School, Worcester, MA, USA., Asirwatham AM; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Massachusetts Memorial Health, University of Massachusetts Chan Medical School, Worcester, MA, USA., Bucci V; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Moormann AM; Department of Medicine. Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Maldonado-Contreras A; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA. Ana.Maldonado@umassmed.edu. |
المصدر: | Microbiome [Microbiome] 2023 Jun 26; Vol. 11 (1), pp. 141. Date of Electronic Publication: 2023 Jun 26. |
نوع المنشور: | Video-Audio Media; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101615147 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-2618 (Electronic) Linking ISSN: 20492618 NLM ISO Abbreviation: Microbiome Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London: BioMed Central, 2013- |
مواضيع طبية MeSH: | COVID-19* , Microbiota*, Humans ; Infant ; Female ; Pregnancy ; SARS-CoV-2 ; Pregnant Women ; Parturition |
مستخلص: | Background: Infants receive their first bacteria from their birthing parent. This newly acquired microbiome plays a pivotal role in developing a robust immune system, the cornerstone of long-term health. Results: We demonstrated that the gut, vaginal, and oral microbial diversity of pregnant women with SARS-CoV-2 infection is reduced, and women with early infections exhibit a different vaginal microbiota composition at the time of delivery compared to their healthy control counterparts. Accordingly, a low relative abundance of two Streptococcus sequence variants (SV) was predictive of infants born to pregnant women with SARS-CoV-2 infection. Conclusions: Our data suggest that SARS-CoV-2 infections during pregnancy, particularly early infections, are associated with lasting changes in the microbiome of pregnant women, compromising the initial microbial seed of their infant. Our results highlight the importance of further exploring the impact of SARS-CoV-2 on the infant's microbiome-dependent immune programming. Video Abstract. (© 2023. The Author(s).) |
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معلومات مُعتمدة: | U01 CA261276 United States CA NCI NIH HHS |
تواريخ الأحداث: | Date Created: 20230626 Date Completed: 20230628 Latest Revision: 20230701 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC10291758 |
DOI: | 10.1186/s40168-023-01577-z |
PMID: | 37365606 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2049-2618 |
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DOI: | 10.1186/s40168-023-01577-z |