دورية أكاديمية
أعرض في EDS

The microbiota of pregnant women with SARS-CoV-2 and their infants.

التفاصيل البيبلوغرافية
العنوان: The microbiota of pregnant women with SARS-CoV-2 and their infants.
المؤلفون: Leftwich HK; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Massachusetts Memorial Health, University of Massachusetts Chan Medical School, Worcester, MA, USA., Vargas-Robles D; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Rojas-Correa M; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Yap YR; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Bhattarai S; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Ward DV; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Fujimori G; Department of Medicine. Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Forconi CS; Department of Medicine. Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Yeboah T; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Massachusetts Memorial Health, University of Massachusetts Chan Medical School, Worcester, MA, USA., Carter A; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Massachusetts Memorial Health, University of Massachusetts Chan Medical School, Worcester, MA, USA., Kastrinakis A; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Massachusetts Memorial Health, University of Massachusetts Chan Medical School, Worcester, MA, USA., Asirwatham AM; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Massachusetts Memorial Health, University of Massachusetts Chan Medical School, Worcester, MA, USA., Bucci V; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA., Moormann AM; Department of Medicine. Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Maldonado-Contreras A; Department of Microbiology and Physiological Systems, Program of Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, MA, USA. Ana.Maldonado@umassmed.edu.
المصدر: Microbiome [Microbiome] 2023 Jun 26; Vol. 11 (1), pp. 141. Date of Electronic Publication: 2023 Jun 26.
نوع المنشور: Video-Audio Media; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101615147 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-2618 (Electronic) Linking ISSN: 20492618 NLM ISO Abbreviation: Microbiome Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London: BioMed Central, 2013-
مواضيع طبية MeSH: COVID-19* , Microbiota*, Humans ; Infant ; Female ; Pregnancy ; SARS-CoV-2 ; Pregnant Women ; Parturition
مستخلص: Background: Infants receive their first bacteria from their birthing parent. This newly acquired microbiome plays a pivotal role in developing a robust immune system, the cornerstone of long-term health.
Results: We demonstrated that the gut, vaginal, and oral microbial diversity of pregnant women with SARS-CoV-2 infection is reduced, and women with early infections exhibit a different vaginal microbiota composition at the time of delivery compared to their healthy control counterparts. Accordingly, a low relative abundance of two Streptococcus sequence variants (SV) was predictive of infants born to pregnant women with SARS-CoV-2 infection.
Conclusions: Our data suggest that SARS-CoV-2 infections during pregnancy, particularly early infections, are associated with lasting changes in the microbiome of pregnant women, compromising the initial microbial seed of their infant. Our results highlight the importance of further exploring the impact of SARS-CoV-2 on the infant's microbiome-dependent immune programming. Video Abstract.
(© 2023. The Author(s).)
References: Contemp Clin Trials Commun. 2020 May 04;18:100573. (PMID: 32617430)
Science. 2012 Apr 27;336(6080):489-93. (PMID: 22442383)
BMJ. 2020 Sep 1;370:m3320. (PMID: 32873575)
BMC Pregnancy Childbirth. 2022 Jun 23;22(1):511. (PMID: 35739474)
J Crohns Colitis. 2013 Aug;7(7):542-50. (PMID: 23036507)
Am J Gastroenterol. 2008 Jan;103(1):162-9. (PMID: 17916108)
Emerg Microbes Infect. 2020 Dec;9(1):382-385. (PMID: 32065055)
Inflamm Bowel Dis. 2012 May;18(5):857-62. (PMID: 21739532)
Int J Environ Res Public Health. 2021 May 23;18(11):. (PMID: 34071058)
Nat Med. 2016 Mar;22(3):250-3. (PMID: 26828196)
Lancet Microbe. 2022 Oct;3(10):e787-e794. (PMID: 36088916)
Am J Gastroenterol. 2010 Jan;105(1):162-9. (PMID: 19755969)
Gut. 2022 Jan;71(1):222-225. (PMID: 33833065)
Cell Host Microbe. 2023 Mar 8;31(3):447-460.e6. (PMID: 36893737)
Infect Immun. 2021 Apr 16;89(5):. (PMID: 33558324)
Nat Methods. 2016 Jul;13(7):581-3. (PMID: 27214047)
Benef Microbes. 2017 Oct 13;8(5):763-778. (PMID: 29022384)
PLoS One. 2013 Apr 22;8(4):e61217. (PMID: 23630581)
Gut. 2019 Feb;68(2):218-225. (PMID: 29321166)
Sci Rep. 2019 Jul 22;9(1):10550. (PMID: 31332213)
Sci Rep. 2022 Aug 4;12(1):13404. (PMID: 35927569)
J Periodontal Res. 2013 Feb;48(1):30-6. (PMID: 22762355)
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11971-5. (PMID: 20566857)
Pediatrics. 2007 Mar;119(3):e724-32. (PMID: 17332189)
Sci China Life Sci. 2022 Jul;65(7):1473-1476. (PMID: 35441283)
Cell Host Microbe. 2021 Aug 11;29(8):1249-1265.e9. (PMID: 34289377)
Cell Rep Med. 2020 Dec 22;1(9):100156. (PMID: 33377127)
J Allergy Clin Immunol. 2016 Mar;137(3):680-9. (PMID: 26806048)
Int J Mol Sci. 2022 Sep 07;23(18):. (PMID: 36142219)
Clin Infect Dis. 2020 Jul 28;71(15):813-817. (PMID: 32241022)
N Engl J Med. 2020 Dec 3;383(23):2255-2273. (PMID: 33264547)
Nat Med. 2019 Jun;25(6):1001-1011. (PMID: 31142850)
NPJ Biofilms Microbiomes. 2021 Mar 11;7(1):21. (PMID: 33707430)
J Clin Pediatr Dent. 2015 Fall;39(5):442-6. (PMID: 26551367)
Appl Environ Microbiol. 2011 Sep;77(18):6718-21. (PMID: 21784919)
Int J Oral Sci. 2020 Apr 30;12(1):12. (PMID: 32350240)
Nature. 2018 Oct;562(7728):589-594. (PMID: 30356183)
Gut Microbes. 2020 Nov 1;11(6):1632-1642. (PMID: 32576065)
J Infect Dis. 2023 Feb 1;227(3):371-380. (PMID: 36314635)
Digestion. 2014;89(4):299-309. (PMID: 25074029)
Front Cell Infect Microbiol. 2022 Dec 01;12:1047607. (PMID: 36530443)
Gut Microbes. 2020 Nov 9;12(1):1-22. (PMID: 33023370)
Nat Rev Gastroenterol Hepatol. 2023 May;20(5):323-337. (PMID: 36271144)
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4680-7. (PMID: 20534435)
Ginekol Pol. 2021 Mar 10;:. (PMID: 33751509)
Anaerobe. 2018 Apr;50:55-59. (PMID: 29409815)
J Immunol Methods. 2020 Sep - Oct;484-485:112832. (PMID: 32780998)
Front Cell Infect Microbiol. 2019 Aug 28;9:294. (PMID: 31555603)
Cell. 2018 Aug 23;174(5):1277-1292.e14. (PMID: 30142345)
Science. 2016 Apr 29;352(6285):539-44. (PMID: 27126036)
Cell. 2012 Jun 22;149(7):1578-93. (PMID: 22726443)
J Crohns Colitis. 2012 May;6(4):412-8. (PMID: 22398068)
Gut. 2022 Nov;71(11):2371-2373. (PMID: 35135843)
Cell Rep Med. 2021 Nov 16;2(11):100453. (PMID: 34723226)
Inflamm Bowel Dis. 2008 Jan;14(1):40-6. (PMID: 18022866)
Exp Dermatol. 2021 Jun;30(6):859-864. (PMID: 33433023)
Neuron. 2019 Jan 16;101(2):246-259.e6. (PMID: 30522820)
Biometrics. 2006 Mar;62(1):245-53. (PMID: 16542252)
Cell Host Microbe. 2018 Jul 11;24(1):133-145.e5. (PMID: 30001516)
Gastroenterology. 2021 Mar;160(4):1118-1130.e3. (PMID: 33307026)
World J Gastroenterol. 2010 Nov 14;16(42):5272-9. (PMID: 21072889)
J Allergy Clin Immunol. 2020 Nov;146(5):1016-1026. (PMID: 32298699)
J Allergy Clin Immunol. 2021 May;147(5):1683-1691. (PMID: 33091409)
Clin Infect Dis. 2020 Dec 17;71(10):2669-2678. (PMID: 32497191)
BMJ Glob Health. 2023 Jan;8(1):. (PMID: 36646475)
Cell Host Microbe. 2015 Feb 11;17(2):260-73. (PMID: 25662751)
Microbiome. 2020 Nov 23;8(1):166. (PMID: 33228810)
PLoS Pathog. 2020 Mar 26;16(3):e1008376. (PMID: 32214382)
Diabetologia. 2021 Aug;64(8):1749-1759. (PMID: 34110438)
Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11060-5. (PMID: 26283357)
Nat Commun. 2021 Oct 13;12(1):5958. (PMID: 34645820)
معلومات مُعتمدة: U01 CA261276 United States CA NCI NIH HHS
تواريخ الأحداث: Date Created: 20230626 Date Completed: 20230628 Latest Revision: 20230701
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10291758
DOI: 10.1186/s40168-023-01577-z
PMID: 37365606
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-2618
DOI:10.1186/s40168-023-01577-z