دورية أكاديمية
أعرض في EDS

Metabolic Silencing via Methionine-Based Amino Acid Restriction in Head and Neck Cancer.

التفاصيل البيبلوغرافية
العنوان: Metabolic Silencing via Methionine-Based Amino Acid Restriction in Head and Neck Cancer.
المؤلفون: Wünsch AC; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Ries E; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Heinzelmann S; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Frabschka A; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Wagner PC; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Rauch T; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Koderer C; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., El-Mesery M; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt., Volland JM; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Kübler AC; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Hartmann S; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Seher A; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany.
المصدر: Current issues in molecular biology [Curr Issues Mol Biol] 2023 May 24; Vol. 45 (6), pp. 4557-4573. Date of Electronic Publication: 2023 May 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100931761 Publication Model: Electronic Cited Medium: Internet ISSN: 1467-3045 (Electronic) Linking ISSN: 14673037 NLM ISO Abbreviation: Curr Issues Mol Biol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2021- : Basel, Switzerland : MDPI
Original Publication: Wymondham, Norfolk, UK : Caister Academic Press,
مستخلص: In recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing age-associated diseases, such as type II diabetes and cardiovascular diseases, but also potential for cancer therapy. These strategies not only reprogram metabolism to low-energy metabolism (LEM), which is disadvantageous for neoplastic cells, but also significantly inhibit proliferation. Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumour types, with over 600,000 new cases diagnosed annually worldwide. With a 5-year survival rate of approximately 55%, the poor prognosis has not improved despite extensive research and new adjuvant therapies. Therefore, for the first time, we analysed the potential of methionine restriction (MetR) in selected HNSCC cell lines. We investigated the influence of MetR on cell proliferation and vitality, the compensation for MetR by homocysteine, the gene regulation of different amino acid transporters, and the influence of cisplatin on cell proliferation in different HNSCC cell lines.
References: Exp Gerontol. 2013 Oct;48(10):1120-8. (PMID: 23454633)
Cell. 2006 Jul 28;126(2):257-68. (PMID: 16873059)
Metabolites. 2021 Jan 31;11(2):. (PMID: 33572567)
CA Cancer J Clin. 2015 Mar;65(2):87-108. (PMID: 25651787)
Aging Cell. 2019 Feb;18(1):e12876. (PMID: 30430746)
Oncogene. 2011 Jul 28;30(30):3305-16. (PMID: 21516129)
Cell Metab. 2016 Apr 12;23(4):580-9. (PMID: 27076075)
Amino Acids. 2017 Dec;49(12):2091-2098. (PMID: 28929442)
Nat Cell Biol. 2019 Jan;21(1):63-71. (PMID: 30602761)
Metabolites. 2021 Jan 02;11(1):. (PMID: 33401672)
Transl Oncol. 2022 Jul;21:101426. (PMID: 35460943)
PLoS Genet. 2014 May 01;10(5):e1004347. (PMID: 24785424)
Science. 2009 May 22;324(5930):1029-33. (PMID: 19460998)
Cancers (Basel). 2021 Jan 02;13(1):. (PMID: 33401748)
Int J Mol Sci. 2021 Oct 27;22(21):. (PMID: 34769059)
Cell Metab. 2019 Mar 5;29(3):592-610. (PMID: 30840912)
Cell. 2017 Mar 9;168(6):960-976. (PMID: 28283069)
J Clin Oncol. 2006 May 10;24(14):2137-50. (PMID: 16682732)
Front Genet. 2016 Aug 18;7:142. (PMID: 27588026)
Biochem Pharmacol. 2018 Aug;154:170-173. (PMID: 29733806)
J Nutr Biochem. 1990 May;1(5):228-37. (PMID: 15539209)
Curr Med Chem. 2013;20(31):3872-902. (PMID: 23848535)
Trends Endocrinol Metab. 2014 Nov;25(11):558-66. (PMID: 25153840)
Nature. 2020 Sep;585(7824):277-282. (PMID: 32879489)
Front Pharmacol. 2021 Jan 11;11:582587. (PMID: 33510635)
Nutr Metab (Lond). 2020 Aug 26;17:73. (PMID: 32863845)
Immunol Cell Biol. 2020 Sep;98(8):623-625. (PMID: 32842169)
Biomed Res Int. 2014;2014:506287. (PMID: 25250324)
Cell Metab. 2014 Mar 4;19(3):407-17. (PMID: 24606898)
Dev Cell. 2016 Mar 7;36(5):540-9. (PMID: 26954548)
Cancer Treat Rev. 2012 Oct;38(6):726-36. (PMID: 22342103)
Int J Mol Sci. 2022 Aug 16;23(16):. (PMID: 36012485)
J Biol Chem. 2005 Mar 25;280(12):12002-11. (PMID: 15659399)
Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
Bioorg Chem. 2019 Jul;88:102925. (PMID: 31003078)
Int J Mol Sci. 2018 Oct 19;19(10):. (PMID: 30347687)
فهرسة مساهمة: Keywords: HNSCC; SCCHN; SLC-family; amino acid restriction; amino acid transporter; caloric restriction; cell vitality; cisplatin; low energy metabolism; methionine
تواريخ الأحداث: Date Created: 20230627 Latest Revision: 20230701
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10297726
DOI: 10.3390/cimb45060289
PMID: 37367038
قاعدة البيانات: MEDLINE
الوصف
تدمد:1467-3045
DOI:10.3390/cimb45060289