دورية أكاديمية
أعرض في EDS

Engineered Human Tissue as A New Platform for Mosquito Bite-Site Biology Investigations.

التفاصيل البيبلوغرافية
العنوان: Engineered Human Tissue as A New Platform for Mosquito Bite-Site Biology Investigations.
المؤلفون: Seavey CE; Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL 32827, USA., Doshi M; Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL 32827, USA., Panarello AP; Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL 32827, USA., Felice MA; Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL 32827, USA., Dickerson AK; Department of Mechanical, Aerospace, and Biomedical Engineering, Tickle College of Engineering, University of Tennessee, Knoxville, TN 37996, USA., Jewett MW; Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, FL 32827, USA., Willenberg BJ; Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL 32827, USA.
المصدر: Insects [Insects] 2023 Jun 02; Vol. 14 (6). Date of Electronic Publication: 2023 Jun 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101574235 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4450 (Print) Linking ISSN: 20754450 NLM ISO Abbreviation: Insects Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2010]-
مستخلص: Vector-borne diseases transmitted through the bites of hematophagous arthropods, such as mosquitoes, continue to be a significant threat to human health globally. Transmission of disease by biting arthropod vectors includes interactions between (1) saliva expectorated by a vector during blood meal acquisition from a human host, (2) the transmitted vector-borne pathogens, and (3) host cells present at the skin bite site. Currently, the investigation of bite-site biology is challenged by the lack of model 3D human skin tissues for in vitro analyses. To help fill this gap, we have used a tissue engineering approach to develop new stylized human dermal microvascular bed tissue approximates-complete with warm blood-built with 3D capillary alginate gel (Capgel) biomaterial scaffolds. These engineered tissues, termed a Biologic Interfacial Tissue-Engineered System (BITES), were cellularized with either human dermal fibroblasts (HDFs) or human umbilical vein endothelial cells (HUVECs). Both cell types formed tubular microvessel-like tissue structures of oriented cells (82% and 54% for HDFs and HUVECs, respectively) lining the unique Capgel parallel capillary microstructures. Female Aedes ( Ae .) aegypti mosquitoes, a prototypic hematophagous biting vector arthropod, swarmed, bit, and probed blood-loaded HDF BITES microvessel bed tissues that were warmed (34-37 °C), acquiring blood meals in 151 ± 46 s on average, with some ingesting ≳4 µL or more of blood. Further, these tissue-engineered constructs could be cultured for at least three (3) days following blood meal acquisitions. Altogether, these studies serve as a powerful proof-of-concept demonstration of the innovative BITES platform and indicate its potential for the future investigation of arthropod bite-site cellular and molecular biology.
References: Biomaterials. 2010 Sep;31(27):6941-6951. (PMID: 20638973)
Front Physiol. 2021 Mar 02;11:623769. (PMID: 33737879)
Parasit Vectors. 2022 Mar 5;15(1):79. (PMID: 35248154)
Gels. 2022 Jun 14;8(6):. (PMID: 35735720)
Lancet. 2016 Oct 8;388(10053):1603-1658. (PMID: 27733283)
Front Zool. 2010 Jan 21;7:3. (PMID: 20205866)
Virology. 2014 Sep;464-465:26-32. (PMID: 25043586)
J Biomater Sci Polym Ed. 2011;22(12):1621-37. (PMID: 20699061)
PLoS Negl Trop Dis. 2018 May 17;12(5):e0006439. (PMID: 29771921)
Trop Biomed. 2005 Jun;22(1):69-71. (PMID: 16880756)
Circ Res. 1981 Apr;48(4):481-8. (PMID: 7460219)
Biochem Soc Trans. 2011 Dec;39(6):1597-600. (PMID: 22103493)
Biol Open. 2013 Aug 14;2(10):1007-12. (PMID: 24167710)
J Exp Biol. 1977 Aug;69:53-85. (PMID: 908912)
Nat Commun. 2021 Oct 14;12(1):6018. (PMID: 34650045)
J Control Release. 2007 Mar 12;118(1):18-26. (PMID: 17254662)
J Med Entomol. 1975 Apr 30;12(1):99-103. (PMID: 240029)
Methods Mol Biol. 2017;1612:191-198. (PMID: 28634944)
Infect Genet Evol. 2016 Jun;40:126-135. (PMID: 26925703)
J Virol. 2011 Feb;85(4):1517-27. (PMID: 21147918)
J Investig Dermatol Symp Proc. 2000 Dec;5(1):3-9. (PMID: 11147672)
J Virol. 2015 Sep;89(17):8880-96. (PMID: 26085147)
J Cell Sci. 2004 Feb 15;117(Pt 5):667-75. (PMID: 14754903)
Front Cell Infect Microbiol. 2020 Aug 07;10:407. (PMID: 32850501)
Lancet. 2018 Nov 10;392(10159):1789-1858. (PMID: 30496104)
J Biomed Mater Res A. 2006 Nov;79(2):440-50. (PMID: 16941595)
Exp Parasitol. 1985 Aug;60(1):118-32. (PMID: 3839460)
J Invest Dermatol. 2014 Jan;134(1):281-284. (PMID: 23752041)
Sci Adv. 2021 Feb 5;7(6):. (PMID: 33547079)
Microvasc Res. 2019 Mar;122:60-70. (PMID: 30472038)
PLoS Negl Trop Dis. 2020 Sep 25;14(9):e0008654. (PMID: 32976503)
Front Bioeng Biotechnol. 2023 Feb 09;11:1103748. (PMID: 36845184)
Environ Entomol. 2023 Apr 18;52(2):197-209. (PMID: 36794837)
Immunol Rev. 2008 Oct;225:27-45. (PMID: 18837774)
J Tissue Eng Regen Med. 2019 Mar;13(3):385-395. (PMID: 30636354)
PLoS Negl Trop Dis. 2018 Nov 12;12(11):e0006880. (PMID: 30418969)
J Exp Biol. 2005 Oct;208(Pt 20):3971-86. (PMID: 16215223)
Am J Physiol Cell Physiol. 2006 May;290(5):C1385-98. (PMID: 16601149)
Blood. 2010 Mar 4;115(9):1823-34. (PMID: 20042723)
Sci Rep. 2016 Jul 12;6:29510. (PMID: 27404382)
J Vector Ecol. 2014 Dec;39(2):271-7. (PMID: 25424255)
Int J Cardiol. 2016 Oct 1;220:149-54. (PMID: 27379917)
Int J Exp Pathol. 2005 Oct;86(5):323-34. (PMID: 16191104)
PLoS Biol. 2020 Jun 8;18(6):e3000723. (PMID: 32511224)
PLoS One. 2020 May 29;15(5):e0233618. (PMID: 32469954)
J Chem Ecol. 2021 May;47(4-5):351-393. (PMID: 33725235)
J Med Entomol. 1985 Nov 27;22(6):612-8. (PMID: 4078846)
Pharm Res. 2022 Apr;39(4):783-793. (PMID: 35266087)
Acta Trop. 2018 Jul;183:43-56. (PMID: 29625092)
JID Innov. 2022 Apr 12;2(4):100128. (PMID: 35812722)
PLoS Negl Trop Dis. 2013 Jun 13;7(6):e2237. (PMID: 23785528)
J Immunol. 1998 Dec 1;161(11):6338-46. (PMID: 9834124)
PLoS Pathog. 2016 Jun 16;12(6):e1005676. (PMID: 27310141)
Curr Biol. 2012 Jan 10;22(1):40-5. (PMID: 22177900)
Arthropod Struct Dev. 2012 Mar;41(2):101-18. (PMID: 22317988)
Immunity. 2016 Jun 21;44(6):1455-69. (PMID: 27332734)
J Infect Dis. 2014 Jun 15;209 Suppl 2:S71-8. (PMID: 24872400)
J Neurosci Methods. 2018 Jul 15;305:46-53. (PMID: 29746890)
Int J Mol Sci. 2019 Apr 05;20(7):. (PMID: 30959732)
Eur J Immunol. 2011 Dec;41(12):3396-400. (PMID: 22125007)
PLoS Pathog. 2019 Dec 2;15(12):e1008218. (PMID: 31790509)
Front Physiol. 2015 Oct 29;6:306. (PMID: 26578978)
NPJ Regen Med. 2020 Jan 6;5:1. (PMID: 31934351)
معلومات مُعتمدة: R01 AI099094 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Aedes aegypti; Capgel; arthropods; blood-feeding; mosquitoes
تواريخ الأحداث: Date Created: 20230627 Latest Revision: 20230930
رمز التحديث: 20230930
مُعرف محوري في PubMed: PMC10299109
DOI: 10.3390/insects14060514
PMID: 37367330
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4450
DOI:10.3390/insects14060514