دورية أكاديمية
Therapeutic Efficacy of AFree Oral Spray on the Symptoms and Course of Moderate and Severe COVID-19 in the Field Hospital.
| العنوان: | Therapeutic Efficacy of AFree Oral Spray on the Symptoms and Course of Moderate and Severe COVID-19 in the Field Hospital. |
|---|---|
| المؤلفون: | Tran DT; 19-8 Hospital, Ministry of Public Security, Hanoi, Vietnam.; Faculty of Medicine, Dai Nam University, Hanoi, Vietnam., Pham TN; 19-8 Hospital, Ministry of Public Security, Hanoi, Vietnam.; Department of Experimental Surgery and Preclinical Study - University of Medicine and Pharmacy, Hanoi National University, Hanoi, Vietnam., Nguyen NHT; Department of Clinical Laboratory, University of Medical Technology, Hai Duong, Vietnam., Tran HD; Department of Oncology, National Children Hospital, Hanoi, Vietnam., Hoang HQ; Natural Health Medical Center, Lawndale, CA, U.S.A., Nguyen AK; Inventive Medical Foundation, South El Monte, CA, U.S.A., Han BO; Nimni-Cordoba Tissue Engineering and Drug Discovery Lab, Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, U.S.A., Hoang BX; Nimni-Cordoba Tissue Engineering and Drug Discovery Lab, Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, U.S.A. baxuanho@usc.edu. |
| المصدر: | In vivo (Athens, Greece) [In Vivo] 2023 Jul-Aug; Vol. 37 (4), pp. 1743-1750. |
| نوع المنشور: | Randomized Controlled Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8806809 Publication Model: Print Cited Medium: Internet ISSN: 1791-7549 (Electronic) Linking ISSN: 0258851X NLM ISO Abbreviation: In Vivo Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000- > : Attiki, Greece : International Institute of Anticancer Research Original Publication: Athens : Dr. J.G. Delinassios |
| مواضيع طبية MeSH: | COVID-19*, Humans ; Oral Sprays ; SARS-CoV-2 ; COVID-19 Drug Treatment ; Prospective Studies ; Mobile Health Units ; Treatment Outcome |
| مستخلص: | Background/aim: A prospective randomized, open-label, single-blinded clinical trial was conducted to evaluate the efficacy of AFree on the symptoms and course of moderate and severe COVID-19 in the field hospital. Patients and Methods: Two hundred hospitalized patients diagnosed with COVID-19 were enrolled. The patients were randomized into 100 patients in the interventional AFree group and 100 in the control group. The AFree group patients were treated with AFree oral spray in conjunction with the standard COVID-19 treatment protocol, while the control group of patients were treated with only standard care. Results: Patients of the AFree group demonstrated a remarkedly faster improvement in all COVID-19-related symptoms, resulting in a shorter time for complete recovery than the control group. More importantly, they showed a shorter time for complete viral clearance. Adding AFree to the standard of care protocol also significantly improved the restoration of taste and smell and reduced lung infiltration. Additionally, the patients in the AFree group also exhibited fewer adverse effects related to treatment. Conclusion: AFree oral spray is a simple-to-use, safe, and effective adjunctive treatment for moderate and severe COVID-19 cases. AFree oral spray was demonstrated to potentially be effective for COVID-19 prevention. (Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.) |
| References: | Int J Oral Sci. 2020 Mar 3;12(1):9. (PMID: 32127517) J Glob Antimicrob Resist. 2020 Dec;23:256-262. (PMID: 33065330) J Ocul Pharmacol Ther. 2021 Oct;37(8):441-451. (PMID: 34314611) J Nutr Biochem. 2021 Mar;89:108563. (PMID: 33326841) Med Hypotheses. 2020 Dec;145:110333. (PMID: 33045596) Jpn Dent Sci Rev. 2021 Nov;57:39-45. (PMID: 33747261) Int J Oral Sci. 2020 Apr 17;12(1):11. (PMID: 32300101) Med Hypotheses. 2020 Oct;143:109866. (PMID: 32473509) J Med Virol. 2020 May;92(5):479-490. (PMID: 32052466) Clin Infect Dis. 2020 Jul 28;71(15):841-843. (PMID: 32047895) J Infect Public Health. 2020 Dec;13(12):1811-1817. (PMID: 32948484) |
| فهرسة مساهمة: | Keywords: AFree; COVID-19; DMSO; Iodide; SARS-CoV-2; Zinc; dimethyl sulfoxide; viral infection |
| المشرفين على المادة: | 0 (Oral Sprays) |
| تواريخ الأحداث: | Date Created: 20230627 Date Completed: 20230629 Latest Revision: 20230717 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10347933 |
| DOI: | 10.21873/invivo.13262 |
| PMID: | 37369463 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1791-7549 |
|---|---|
| DOI: | 10.21873/invivo.13262 |