دورية أكاديمية
Treatment of Periodontal Infections, the Possible Role of Hydrogels as Antibiotic Drug-Delivery Systems.
| العنوان: | Treatment of Periodontal Infections, the Possible Role of Hydrogels as Antibiotic Drug-Delivery Systems. |
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| المؤلفون: | Mensah A; School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine BT52 1SA, UK., Rodgers AM; The Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, 96 Lisburn Road, Belfast BT9 7BL, UK., Larrañeta E; School of Pharmacy, Queen's University Belfast, 96 Lisburn Road, Belfast BT9 7BL, UK., McMullan L; DJ Maguire and Associates, Floor 1, Molesworth Place, Molesworth Street, Cookstown BT80 8NX, UK., Tambuwala M; Lincoln Medical School, Universities of Nottingham and Lincoln, Brayford Pool Campus, Lincoln LN6 7TS, UK., Callan JF; School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine BT52 1SA, UK., Courtenay AJ; School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine BT52 1SA, UK. |
| المصدر: | Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2023 Jun 19; Vol. 12 (6). Date of Electronic Publication: 2023 Jun 19. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101637404 Publication Model: Electronic Cited Medium: Print ISSN: 2079-6382 (Print) Linking ISSN: 20796382 NLM ISO Abbreviation: Antibiotics (Basel) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, 2012- |
| مستخلص: | With the advancement of biomedical research into antimicrobial treatments for various diseases, the source and delivery of antibiotics have attracted attention. In periodontal diseases, antibiotics are integral in positive treatment outcomes; however, the use of antibiotics is with caution as the potential for the emergence of resistant strains is of concern. Over the years, conventional routes of drug administration have been proven to be effective for the treatment of PD, yet the problem of antibiotic resistance to conventional therapies continues to remain a setback in future treatments. Hydrogels fabricated from natural and synthetic polymers have been extensively applied in biomedical sciences for the delivery of potent biological compounds. These polymeric materials either have intrinsic antibacterial properties or serve as good carriers for the delivery of antibacterial agents. The biocompatibility, low toxicity and biodegradability of some hydrogels have favoured their consideration as prospective carriers for antibacterial drug delivery in PD. This article reviews PD and its antibiotic treatment options, the role of bacteria in PD and the potential of hydrogels as antibacterial agents and for antibiotic drug delivery in PD. Finally, potential challenges and future directions of hydrogels for use in PD treatment and diagnosis are also highlighted. |
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| فهرسة مساهمة: | Keywords: antibiotic therapy; antimicrobial resistance; dental; drug delivery; hydrogel; periodontal disease |
| تواريخ الأحداث: | Date Created: 20230628 Latest Revision: 20230701 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10295802 |
| DOI: | 10.3390/antibiotics12061073 |
| PMID: | 37370392 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2079-6382 |
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| DOI: | 10.3390/antibiotics12061073 |