دورية أكاديمية
أعرض في EDS

Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis.

التفاصيل البيبلوغرافية
العنوان: Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis.
المؤلفون: Kobzeva KA; Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia., Soldatova MO; Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia., Stetskaya TA; Laboratory of Statistical Genetics and Bioinformatics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia., Soldatov VO; Laboratory of Genome Editing for Biomedicine and Animal Health, Belgorod State National Research University, 308015 Belgorod, Russia.; Department of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, 308015 Belgorod, Russia., Deykin AV; Laboratory of Genome Editing for Biomedicine and Animal Health, Belgorod State National Research University, 308015 Belgorod, Russia.; Department of Pharmacology and Clinical Pharmacology, Belgorod State National Research University, 308015 Belgorod, Russia., Freidin MB; Department of Biology, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, UK.; Laboratory of Population Genetics, Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science, 634050 Tomsk, Russia., Bykanova MA; Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia., Churnosov MI; Department of Medical Biological Disciplines, Belgorod State University, 308015 Belgorod, Russia., Polonikov AV; Laboratory of Statistical Genetics and Bioinformatics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.; Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 305041 Kursk, Russia., Bushueva OY; Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.; Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 305041 Kursk, Russia.
المصدر: Genes [Genes (Basel)] 2023 May 27; Vol. 14 (6). Date of Electronic Publication: 2023 May 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Heat-Shock Proteins*/genetics , Ischemic Stroke*, Male ; Humans ; Pilot Projects ; HSC70 Heat-Shock Proteins/genetics ; Genotype
مستخلص: HSPA8 is involved in many stroke-associated cellular processes, playing a pivotal role in the protein quality control system. Here we report the results of the pilot study aimed at determining whether HSPA8 SNPs are linked to the risk of ischemic stroke (IS). DNA samples from 2139 Russians (888 IS patients and 1251 healthy controls) were genotyped for tagSNPs (rs1461496, rs10892958, and rs1136141) in the HSPA8 gene using probe-based PCR. SNP rs10892958 of HSPA8 was associated with an increased risk (risk allele G) of IS in smokers (OR = 1.37; 95% CI = 1.07-1.77; p = 0.01) and patients with low fruit and vegetable consumption (OR = 1.36; 95% CI = 1.14-1.63; p = 0.002). SNP rs1136141 of HSPA8 was also associated with an increased risk of IS (risk allele A) exclusively in smokers (OR = 1.68; 95% CI = 1.23-2.28; p = 0.0007) and in patients with a low fruit and vegetable intake (OR = 1.29; 95% CI = 1.05-1.60; p = 0.04). Sex-stratified analysis revealed an association of rs10892958 HSPA8 with an increased risk of IS in males (risk allele G; OR = 1.30; 95% CI = 1.05-1.61; p = 0.01). Thus, SNPs rs10892958 and rs1136141 in the HSPA8 gene represent novel genetic markers of IS.
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فهرسة مساهمة: Keywords: HSC70; HSPA8; chaperones; fruit and vegetable intake; gene-environmental interaction; heat shock proteins; ischemic stroke; rs10892958; rs1136141; smoking
المشرفين على المادة: 0 (Heat-Shock Proteins)
0 (HSC70 Heat-Shock Proteins)
0 (HSPA8 protein, human)
تواريخ الأحداث: Date Created: 20230628 Date Completed: 20230629 Latest Revision: 20230701
رمز التحديث: 20230702
مُعرف محوري في PubMed: PMC10298525
DOI: 10.3390/genes14061171
PMID: 37372351
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes14061171