دورية أكاديمية
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The Crosstalk between Gut Microbiota and Nervous System: A Bidirectional Interaction between Microorganisms and Metabolome.

التفاصيل البيبلوغرافية
العنوان: The Crosstalk between Gut Microbiota and Nervous System: A Bidirectional Interaction between Microorganisms and Metabolome.
المؤلفون: Montagnani M; Department of Precision and Regenerative Medicine and Ionian Area-Section of Pharmacology, School of Medicine, University of Bari 'Aldo Moro', Policlinico University Hospital of Bari, Piazza G. Cesare 11, 70124 Bari, Italy., Bottalico L; School of Technical Medical Sciences, 'Alexander Xhuvani' University of Elbasan, 3001-3006 Elbasan, Albania., Potenza MA; Department of Precision and Regenerative Medicine and Ionian Area-Section of Pharmacology, School of Medicine, University of Bari 'Aldo Moro', Policlinico University Hospital of Bari, Piazza G. Cesare 11, 70124 Bari, Italy., Charitos IA; Pneumology and Respiratory Rehabilitation Division, Maugeri Clinical Scientific Research Institutes (IRCCS), 70124 Bari, Italy., Topi S; School of Technical Medical Sciences, 'Alexander Xhuvani' University of Elbasan, 3001-3006 Elbasan, Albania., Colella M; Interdisciplinary Department of Medicine, Microbiology and Virology Unit, School of Medicine, University of Bari 'Aldo Moro', Piazza G. Cesare, 11, 70124 Bari, Italy., Santacroce L; Interdisciplinary Department of Medicine, Microbiology and Virology Unit, School of Medicine, University of Bari 'Aldo Moro', Piazza G. Cesare, 11, 70124 Bari, Italy.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 19; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 19.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Gastrointestinal Microbiome* , Nervous System*/metabolism, Humans ; Animals ; Enteric Nervous System ; Brain-Gut Axis ; Intestines/metabolism ; Intestines/microbiology ; Nervous System Diseases/metabolism ; Nervous System Diseases/microbiology ; Nervous System Diseases/pathology ; Dysbiosis/metabolism ; Dysbiosis/microbiology ; Dysbiosis/pathology
مستخلص: Several studies have shown that the gut microbiota influences behavior and, in turn, changes in the immune system associated with symptoms of depression or anxiety disorder may be mirrored by corresponding changes in the gut microbiota. Although the composition/function of the intestinal microbiota appears to affect the central nervous system (CNS) activities through multiple mechanisms, accurate epidemiological evidence that clearly explains the connection between the CNS pathology and the intestinal dysbiosis is not yet available. The enteric nervous system (ENS) is a separate branch of the autonomic nervous system (ANS) and the largest part of the peripheral nervous system (PNS). It is composed of a vast and complex network of neurons which communicate via several neuromodulators and neurotransmitters, like those found in the CNS. Interestingly, despite its tight connections to both the PNS and ANS, the ENS is also capable of some independent activities. This concept, together with the suggested role played by intestinal microorganisms and the metabolome in the onset and progression of CNS neurological (neurodegenerative, autoimmune) and psychopathological (depression, anxiety disorders, autism) diseases, explains the large number of investigations exploring the functional role and the physiopathological implications of the gut microbiota/brain axis.
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فهرسة مساهمة: Keywords: Enteric Nervous System (ENS); biochemistry; dysbiosis; gut/brain axis; human microbiota; immunity; metabolome; neurotransmitters; probiotics; psychobiotics
تواريخ الأحداث: Date Created: 20230628 Date Completed: 20230629 Latest Revision: 20240314
رمز التحديث: 20240314
مُعرف محوري في PubMed: PMC10299104
DOI: 10.3390/ijms241210322
PMID: 37373470
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms241210322